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[ CAS No. 91424-40-7 ]

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Chemical Structure| 91424-40-7
Chemical Structure| 91424-40-7
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Product Details of [ 91424-40-7 ]

CAS No. :91424-40-7 MDL No. :MFCD00075235
Formula : C11H20O4Si Boiling Point : 302.4°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :244.36 g/mol Pubchem ID :4141040
Synonyms :

Safety of [ 91424-40-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 91424-40-7 ]

  • Upstream synthesis route of [ 91424-40-7 ]
  • Downstream synthetic route of [ 91424-40-7 ]

[ 91424-40-7 ] Synthesis Path-Upstream   1~9

  • 1
  • [ 91424-39-4 ]
  • [ 91424-40-7 ]
YieldReaction ConditionsOperation in experiment
68% With sodium hydroxide; acetic anhydride In methanol; diethyl ether; benzene B.
4-[[(Dimethylethyl)dimethylsilyl]oxy]dihydro-2H-pyran-2,6(3H)-dione
A solution of Part A silyl-ether (theory 63.6 g, 200 mmole) in methanol (200 ml) was treated with NaOH pellets (16.0 g, 400 mmole) and stirred at room temperature under argon for 18 hours.
The cloudy yellow solution was evaporated to dryness and dried in vacuo to give the diNa salt as a pale yellow solid.
The diNa salt (42.1 g) was suspended in benzene (400 ml), treated with acetic anhydride (200 ml) and refluxed under argon for 1.5 hours.
The brown mixture was concentrated in vacuo and the residue partitioned between ethyl acetate and half-saturated NaHCO3 solution.
The organic phase was washed with half saturated NaHCO3 and saturated NaCl solutions, dried over Na2 SO4 and evaporated to give the crude title anhydride as a brown solid.
The crude product was taken up in ethyl ether, treated with Darco (3 g), filtered through Celite and evaporated.
The crystalline residue was triturated with cold hexane to give pure title anhydride (33.26 g, 68percent overall from diethyl 3-hydroxy glutarate) as white plates, m.p. 77°-78° C., C13 -NMR (15 MHz, CDCl3)--5.22 ppm, 17.64, 25.31, 38.88, 61.87, 165.26.
Reference: [1] Patent: US4804770, 1989, A,
[2] Journal of Organic Chemistry, 1984, vol. 49, # 19, p. 3657 - 3659
[3] Journal of Organic Chemistry, 1988, vol. 53, # 10, p. 2374 - 2378
[4] Journal of Medicinal Chemistry, 1987, vol. 30, # 10, p. 1858 - 1873
[5] European Journal of Organic Chemistry, 2014, vol. 2014, # 3, p. 631 - 638
[6] Patent: CN107011378, 2017, A,
  • 2
  • [ 113794-48-2 ]
  • [ 91424-40-7 ]
YieldReaction ConditionsOperation in experiment
90% at 130 - 135℃; for 2 - 3 h; Example 1. Preparation of 3-hvdroxy protected glutaric anhydride, compound of formula 3. A four-neck round bottom flask fitted with a mechanical stirrer, condenser, and charging tube was charged with acetic anhydride (609 ml) followed by charging of 3-hydroxy protected glutaric acid at 25 to 300C. The reaction mass was refluxed for 2-3 hours at 130-1350C. The unreacted acetic anhydride, along with acetic acid, was completely distilled under vacuum at 60-950C. The product was crystallized from cyclohexane, and dried to obtain 90-95 percent of a brown crystalline solid with GC purity of 97.2 percent.
Reference: [1] Patent: WO2008/130638, 2008, A2, . Location in patent: Page/Page column 30-31
[2] Journal of Medicinal Chemistry, 1987, vol. 30, # 10, p. 1858 - 1873
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 3, p. 631 - 638
  • 3
  • [ 32328-03-3 ]
  • [ 91424-40-7 ]
Reference: [1] Journal of Medicinal Chemistry, 1987, vol. 30, # 10, p. 1858 - 1873
[2] Journal of Organic Chemistry, 1988, vol. 53, # 10, p. 2374 - 2378
[3] Journal of Organic Chemistry, 1984, vol. 49, # 19, p. 3657 - 3659
[4] European Journal of Organic Chemistry, 2014, vol. 2014, # 3, p. 631 - 638
[5] Patent: CN107011378, 2017, A,
  • 4
  • [ 18162-48-6 ]
  • [ 91424-40-7 ]
Reference: [1] Journal of Medicinal Chemistry, 1987, vol. 30, # 10, p. 1858 - 1873
[2] Journal of Organic Chemistry, 1988, vol. 53, # 10, p. 2374 - 2378
[3] Journal of Organic Chemistry, 1984, vol. 49, # 19, p. 3657 - 3659
[4] European Journal of Organic Chemistry, 2014, vol. 2014, # 3, p. 631 - 638
[5] Patent: CN107011378, 2017, A,
  • 5
  • [ 18162-48-6 ]
  • [ 152294-14-9 ]
  • [ 91424-40-7 ]
Reference: [1] Asian Journal of Chemistry, 2014, vol. 26, # 22, p. 7867 - 7868
  • 6
  • [ 77-92-9 ]
  • [ 91424-40-7 ]
Reference: [1] Asian Journal of Chemistry, 2014, vol. 26, # 22, p. 7867 - 7868
  • 7
  • [ 542-05-2 ]
  • [ 91424-40-7 ]
Reference: [1] Asian Journal of Chemistry, 2014, vol. 26, # 22, p. 7867 - 7868
  • 8
  • [ 91424-40-7 ]
  • [ 147118-35-2 ]
Reference: [1] Patent: WO2011/141934, 2011, A1,
[2] Patent: WO2011/141934, 2011, A1,
[3] Patent: WO2011/141934, 2011, A1,
[4] Patent: CN107011378, 2017, A,
  • 9
  • [ 91424-40-7 ]
  • [ 147118-39-6 ]
Reference: [1] Patent: WO2011/141934, 2011, A1,
[2] Patent: WO2011/141934, 2011, A1,
[3] Patent: WO2011/141934, 2011, A1,
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