Home Cart Sign in  
Chemical Structure| 914654-92-5 Chemical Structure| 914654-92-5

Structure of 914654-92-5

Chemical Structure| 914654-92-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 914654-92-5 ]

CAS No. :914654-92-5
Formula : C6H10N4
M.W : 138.17
SMILES Code : CC1=NN2C(CNCC2)=N1
MDL No. :MFCD11044798
InChI Key :XJQLZEZGFIWRKF-UHFFFAOYSA-N
Pubchem ID :18406955

Safety of [ 914654-92-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 914654-92-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 914654-92-5 ]

[ 914654-92-5 ] Synthesis Path-Downstream   1~5

  • 2
  • [ 914654-92-5 ]
  • 2-bromo-N-[1-(1H-indol-3-yl)hexan-2-yl]-1,3-thiazole-5-carboxamide [ No CAS ]
  • N-[1-(1H-indol-3-ylmethyl)pentyl]-2-(2-methyl-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl)thiazole-5-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
30% With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; ruphos; In 1,4-dioxane; at 100℃; for 15.0h; To a solution of 2-bromo-N-[1-(1 H-indol-3-ylmethyl)pentyl]thiazole-5- carboxamide (0.20 g, 0.49 mmol) and 2-methyl-5,6,7,8-tetrahydro- [1 ,2,4]triazolo[1 ,5-a]pyrazine (0.08 g, 0.59 mmol) in dioxane (8 ml.) NaOtBu (0.07 g, 0.73 mmol) and RuPhos (0.05 g, 0.10 mmol) was added. The reaction mixture was purged with argon for 20 min followed by Pd2(dba)3 (0.05 g, 0.05 mmol) was added and again purged with argon for 10 min. The reaction mixture was heated at 100C for 15h. Progress of the reaction was monitored by TLC and LCMS. After completion, the reaction mixture was diluted with EtOAc (60 ml_), filtered through Celite. The organic layer was separated, washed with H2O (30 ml_), brine (30 ml_), dried over anhydrous Na2SC>4 and concentrated in vacuo. The crude residue obtained was purified by column chromatography (silica 100-200 mesh, 2.5 to 6% MeOH in DCM) and preparative HPLC to afford N-[1-(1 H-indol-3-ylmethyl)pentyl]-2-(2-methyl-6,8- dihydro-5H-[1 ,2,4]triazolo[1 ,5-a]pyrazin-7-yl)thiazole-5-carboxamide (0.07 g, 30%) as off-white solid. HPLC Purity: 99.6% MS (ESI) m/e [M+H]7Rt %: 464.00/2.59/98.6% 1H NMR (400 MHz, DMSO-d6) δ 0.81 (t, J=6.85 Hz, 3H) 1.15 - 1.35 (m, 4H) 1.46-1.58 (m, 2H) 2.24 (s, 3H) 2.78 - 2.94 (m, 2H) 4.04 (t, J=5.14 Hz, 2H) 4.06-4.16 (m, 1 H) 4.21 (t, J=5.38 Hz, 2H) 4.74 (s, 2H) 6.91 - 6.98 (m, 1 H) 7.04 (t, J=7.34 Hz, 1 H) 7.09 (d, J=1.96 Hz, 1 H) 7.31 (d, J=7.82 Hz, 1 H) 7.57 (d, J=7.82 Hz, 1 H) 7.87 (s, 1 H) 8.04 (d, J=8.31 Hz, 1 H) 10.74 (brs, 1 H).
  • 3
  • [ 914654-92-5 ]
  • [ 1365060-89-4 ]
  • C15H15ClN6OS2 [ No CAS ]
  • 4
  • [ 914654-92-5 ]
  • 2,6,8-Trichloropyrimido[5,4-d]pyrimidin-4-ol [ No CAS ]
  • C12H10Cl2N8O [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 25℃; for 12.0h; To a solution of intermediate compound 21 (400 mg, 1.59 mmol, 1 eq) in THF (5 mL) was added DIEA (513.98 mg, 3.98 mmol, 692.69 uL, 2.5 eq) and cooled to 0 C. A solution of 2-methyl-5,6,7,8-tetrahydro-[l,2,4]triazolo[l,5-a]pyrazine (219.79 mg, 1.59 mmol, 1 eq) in THF (5 mL) was drop wise added to the reaction mixture at 0 C. After addition, the mixture was stirred at 25 C for 12 hr. The reaction mixture was concentrated under vacuum. This residue was diluted with aqueous citric acid (1.82 g/ 50 mL) and this suspension was stirred at 20 C for 1 hr. Then the suspension was filtered, and the filter cake was washed by water (20.0 mL x 3) and then dried under vacuum to give the intermediate compound 80 (600 mg, crude) as yellow solid.LCMS (ESI position ion) m/z: (M+H)+: 352.8 (calculated: 352.03)1H NMR (400 MHz, DMSO-d6) d ppm 5.38 (br s, 2H), 4.61 (br s, 2H), 4.24 (br t, J = 5.2 Hz, 2H), 2.23 (s, 3H)
  • 5
  • [ 914654-92-5 ]
  • 2,6,8-Trichloropyrimido[5,4-d]pyrimidin-4-ol [ No CAS ]
  • C24H38N10O5 [ No CAS ]
 

Historical Records

Categories

Similar Product of
[ 914654-92-5 ]

Chemical Structure| 1263378-55-7

A685516 [1263378-55-7]

2-Methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine hydrochloride

Reason: Free-salt

Related Parent Nucleus of
[ 914654-92-5 ]

Other Aromatic Heterocycles

Chemical Structure| 1263378-55-7

A685516 [1263378-55-7]

2-Methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine hydrochloride

Similarity: 0.98

Chemical Structure| 233278-56-3

A118468 [233278-56-3]

5,6,7,8-Tetrahydro[1,2,4]triazolo[1,5-a]pyrazine

Similarity: 0.97

Chemical Structure| 914654-91-4

A352111 [914654-91-4]

2-(tert-Butyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine

Similarity: 0.91

Chemical Structure| 681249-78-5

A253656 [681249-78-5]

2-Cyclopropyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine

Similarity: 0.91

Chemical Structure| 681249-77-4

A308529 [681249-77-4]

2-Cyclopropyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine hydrochloride

Similarity: 0.89