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[ CAS No. 915070-53-0 ]

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Chemical Structure| 915070-53-0
Chemical Structure| 915070-53-0
Structure of 915070-53-0 * Storage: {[proInfo.prStorage]}

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Product Details of [ 915070-53-0 ]

CAS No. :915070-53-0 MDL No. :MFCD06797215
Formula : C7H8BClO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :170.40 g/mol Pubchem ID :-
Synonyms :

Safety of [ 915070-53-0 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 915070-53-0 ]

  • Downstream synthetic route of [ 915070-53-0 ]

[ 915070-53-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 915070-53-0 ]
  • [ 205672-25-9 ]
  • 2-chloro-5-(2-chloro-3-methylphenyl)pyrimidin-4-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
67% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In tetrahydrofuran; water; at 85℃; for 16h;Inert atmosphere; To a stirred solution of <strong>[205672-25-9]5-bromo-2-chloropyrimidin-4-amine</strong> (0.5 g, 2.39 mmol) in THF:H2O (15 ml, 9:1), 2-chloro-3-methylphenyl)boronic acid (2, 0.61 g, 3.58 mol), sodium carbonate (0.71 g, 7.17 mmol) were added. The reaction mixture was degassed with argon for 10 min and Pd(PPh3)4 (0.27 g, 0.24 mmol) was added. The reaction mixture was degassed again with argon and heated at 85 C. with stirring for 16 h. Progress of the reaction was monitored by TLC, which showed consumption of starting material. The reaction mixture was allowed to cool to room temperature and concentrated. The residue was diluted with water (20 mL) and extracted with EtOAc (3*20 mL). The combined organic layer was washed with brine (40 mL), dried over Na2SO4, filtered, and concentrated. The residue was purified by column chromatography [silica gel (100-200 mesh), gradient 6-8% ethyl acetate in hexane] to give 2-chloro-5-(2-chloro-3-methylphenyl)pyrimidin-4-amine (0.4 g, 67%) as a pale yellow solid. MS (ESI+ve): 254.14 1H-NMR (400 MHz; DMSO-d6): delta 7.82 (s, 1H), 7.44-7.46 (d, J=7.20 Hz, 1H), 7.32-7.36 (t, J=7.6 Hz, 1H), 7.18-7.20 (d, J=6.8 Hz, 1H), 2.40 (s, 3H).
  • 2
  • [ 97329-43-6 ]
  • [ 73183-34-3 ]
  • [ 915070-53-0 ]
  • 2-(2-chloro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane [ No CAS ]
YieldReaction ConditionsOperation in experiment
With tetrakis(triphenylphosphine) palladium(0); potassium acetate; In 1,4-dioxane; at 85℃; for 12h;Inert atmosphere; To a stirred solution of <strong>[97329-43-6]1-bromo-2-chloro-3-methylbenzene</strong> (2 g, 9.73 mmol) in 1,4-dioxane (15 mL), 4,4,4?,4?,5,5,5?,5?-octamethyl-2,2?-bi(1,3,2-dioxaborolane) (3.7 g, 14.6 mmol) and potassium acetate (2.86 g, 29.1 mmol) were added. The reaction mixture was degassed with argon for 10 min. Then Pd(PPh3)2Cl2 (1.02 g, 1.45 mmol) was added and heated at 85 C. with stirring for 12 h. The color of the reaction mixture changed from yellow to red and finally to black. Progress of the reaction was monitored by TLC, which showed consumption of starting material. The reaction mixture was cooled to room temperature and filtered through celite, followed by ethyl acetate wash (100 mL). The filtrate was concentrated to dryness under reduced pressure to afford mixtures of product (1.5 g, 60% pure in LCMS) as a red colored oil, which was used directly for the next step.
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