Home Cart 0 Sign in  

[ CAS No. 917111-46-7 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 917111-46-7
Chemical Structure| 917111-46-7
Structure of 917111-46-7 * Storage: {[proInfo.prStorage]}

Quality Control of [ 917111-46-7 ]

Related Doc. of [ 917111-46-7 ]

SDS
Alternatived Products of [ 917111-46-7 ]
Alternatived Products of [ 917111-46-7 ]

Product Details of [ 917111-46-7 ]

CAS No. :917111-46-7 MDL No. :MFCD08458185
Formula : C16H25BN2O4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :320.19 g/mol Pubchem ID :-
Synonyms :

Safety of [ 917111-46-7 ]

Signal Word:Warning Class:
Precautionary Statements:P280-P305+P351+P338 UN#:
Hazard Statements:H302 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 917111-46-7 ]

  • Upstream synthesis route of [ 917111-46-7 ]
  • Downstream synthetic route of [ 917111-46-7 ]

[ 917111-46-7 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 854074-39-8 ]
  • [ 917111-46-7 ]
  • [ 917111-44-5 ]
YieldReaction ConditionsOperation in experiment
57% With potassium carbonate In propan-1-ol; water; toluene at 100℃; for 17 h; EXAMPLE 18 N-Ethyl-N'-[2-methoxy-4-(5-methyl-4-[(1S)-1-pyridin-3-ylbutyl]amino}pyrimidin-2- yl)phenyl]urea Under a nitrogen atmosphere a mixture of 2-chloro-5-methyl-N-[(1S)-1-pyridin-3- ylbutyl] pyrimidin-4-amine (277 mg, 1.0 mmol) 4-[(ethylamino) carbonyl] amino}-3- methoxyphenylboronic acid pinacol diester (416 mg, 1.3 mmol), tetrakis (triphenylphosphine) palladium (0) (116 mg, 0.1 mmol) in toluene-n-propanol (12 mL, 3: 1) was treated with 2M aqueous sodium carbonate solution (750 uL, 1.5 mmol). The resulting mixture was stirred vigorously whilst being heated at 100 °C for 17 hours. Once cool ethyl acetate (25 mL) was added and the mixture washed with Ha0 (6 x 15 mL), brine (20 mL) and dried (Na2SO4). Removal of solvent in vacuo then yielded crude product, which was purified by column chromatography using dichloromethane-methanol- aqueous ammonia (93: 7: 1) as eluent to furnish the product (110 mg, 57percent). lH-n. m. r. (CDCl3) 8 0.99 (t, 3H,/=7. 4 Hz, CH3), 1.18 (t, 3H,/= 7.2 Hz, CH3), 1.33-1. 60 (m, 2H, CH2), 1.82-2. 02 (m, 2H, CH2), 2.11 (s, 3H, Ar-Me), 3.25-3. 39 (m, 2H, CH2), 3.87 (s, 3H, OMe), 4. 80-4. 96 (m, 2H, 2 x NH), 5.26-5. 36 (m, 1H, CH), 6.98 (br s, 1H, Ar-NHCONH), 7.22-7. 28 (m, 1H, ArH), 7. 67-7.72 (m, 2H, ArH), 7.83-7. 88 (m, 1H, ArH), 8.05 (d, 1H, J = 0.8 Hz, ArH), 8.10 (d, 1H, J = 8.2 Hz, ArH), 8.47 (dd, 1H, J = 6. 6,1. 8 Hz, ArH), 8. 69 (d, 1H, j= 2.0 Hz, ArH).
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 16, p. 4639 - 4642
[2] Patent: WO2005/54199, 2005, A1, . Location in patent: Page/Page column 47-48; 65; 66;
Historical Records

Related Functional Groups of
[ 917111-46-7 ]

Organoboron

Chemical Structure| 2096997-11-2

[ 2096997-11-2 ]

1-(2,5-Dimethoxyphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.91

Chemical Structure| 2096997-11-2

[ 2096997-11-2 ]

1-(2,5-Dimethoxyphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.91

Chemical Structure| 2096996-78-8

[ 2096996-78-8 ]

1-(2-Methoxy-5-methylphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.88

Amines

Chemical Structure| 2096997-11-2

[ 2096997-11-2 ]

1-(2,5-Dimethoxyphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.91

Chemical Structure| 2096996-78-8

[ 2096996-78-8 ]

1-(2-Methoxy-5-methylphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.88

Ureas

Chemical Structure| 2096997-11-2

[ 2096997-11-2 ]

1-(2,5-Dimethoxyphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.91

Chemical Structure| 2096996-78-8

[ 2096996-78-8 ]

1-(2-Methoxy-5-methylphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.88

Aryls

Chemical Structure| 2096997-11-2

[ 2096997-11-2 ]

1-(2,5-Dimethoxyphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.91

Amides

Chemical Structure| 2096997-11-2

[ 2096997-11-2 ]

1-(2,5-Dimethoxyphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.91

Ethers

Chemical Structure| 2096997-11-2

[ 2096997-11-2 ]

1-(2,5-Dimethoxyphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.91

Organoboron

Chemical Structure| 2096997-11-2

[ 2096997-11-2 ]

1-(2,5-Dimethoxyphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.91

Chemical Structure| 2096997-11-2

[ 2096997-11-2 ]

1-(2,5-Dimethoxyphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.91

Chemical Structure| 2096996-78-8

[ 2096996-78-8 ]

1-(2-Methoxy-5-methylphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.88

Organoboron

Chemical Structure| 2096997-11-2

[ 2096997-11-2 ]

1-(2,5-Dimethoxyphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.91

Chemical Structure| 2096997-11-2

[ 2096997-11-2 ]

1-(2,5-Dimethoxyphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.91

Chemical Structure| 2096996-78-8

[ 2096996-78-8 ]

1-(2-Methoxy-5-methylphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.88

Esters

Chemical Structure| 2246799-61-9

[ 2246799-61-9 ]

1-Isopropyl-3-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.99

Chemical Structure| 2246746-56-3

[ 2246746-56-3 ]

1-(2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-propylurea

Similarity: 0.98

Chemical Structure| 1914078-77-5

[ 1914078-77-5 ]

1-(tert-Butyl)-3-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.98

Chemical Structure| 2246849-82-9

[ 2246849-82-9 ]

1-Butyl-3-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.98

Chemical Structure| 2246673-66-3

[ 2246673-66-3 ]

1,1-Diethyl-3-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Similarity: 0.95