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Chemical Structure| 917248-49-8 Chemical Structure| 917248-49-8

Structure of 917248-49-8

Chemical Structure| 917248-49-8

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Product Details of [ 917248-49-8 ]

CAS No. :917248-49-8
Formula : C9H9FO2
M.W : 168.17
SMILES Code : OC1CCOC2=C1C=CC(F)=C2
MDL No. :MFCD15529861

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Application In Synthesis of [ 917248-49-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 917248-49-8 ]

[ 917248-49-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 111141-00-5 ]
  • [ 113209-68-0 ]
  • [ 917248-49-8 ]
  • [ 1092938-99-2 ]
YieldReaction ConditionsOperation in experiment
With sodium tetrahydroborate; In methanol; at 0 - 20℃; for 18h; At a temperature of 0 0C, sodium borohydride (7.4 g, 195 mmol) was added portion-wise to a mixture of 7-fluoro-2,3-dihydro-4/-/-chromen-4-one and 8-fluoro-2,3-dihydro-4/-/-chromen-4-one (16.2 g, 97.5 mmol) in methanol (200 ml). After a period of 1 hour at 0 0C and 17 hours at room temperature, the reaction mixture was quenched with saturated ammonium chloride solution (400 ml) and water (200 ml), and extracted with dichloromethane (2 x). The combined organic phases were washed with water and saturated sodium chloride solution, dried over magnesium sulfate, and the solvent was evaporated. The yellow residue crystallized slowly. The title compound was isolated as mixture with 8- fluorochroman-4-ol (16.28 g, 99 % yield).
 

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