[ CAS No. 92053-25-3 ] {[proInfo.proName]}

Name: 92053-25-3|(S)-2-(Pyrrolidin-2-yl)propan-2-ol|97%
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Quality Control of [ 92053-25-3 ]

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Product Details of [ 92053-25-3 ]

CAS No. :	92053-25-3	MDL No. :	MFCD11975452
Formula :	C₇H₁₅NO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	PSXWGNIMIRRWRB-LURJTMIESA-N
M.W :	129.20	Pubchem ID :	12732179
Synonyms :

Safety of [ 92053-25-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 92053-25-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 92053-25-3 ]
Downstream synthetic route of [ 92053-25-3 ]

[ 92053-25-3 ] Synthesis Path-Upstream 1~10

1
[ 118970-92-6 ]
[ 92053-25-3 ]

Reference： [1] Journal of the Chemical Society, Perkin Transactions 1, 2000, # 10, p. 1513 - 1518
[2] Bulletin des Societes Chimiques Belges, 1988, vol. 97, # 8-9, p. 691 - 704
[3] Journal of the American Chemical Society, 2003, vol. 125, # 31, p. 9306 - 9307
[4] Angewandte Chemie - International Edition, 2007, vol. 46, # 44, p. 8431 - 8435
[5] Patent: WO2010/57121, 2010, A1, . Location in patent: Page/Page column 91-92
[6] Angewandte Chemie - International Edition, 2016, vol. 55, # 27, p. 7698 - 7701[7] Angew. Chem., 2016, vol. 128, p. 7829 - 7832,4

2
[ 51207-68-2 ]
[ 92053-25-3 ]

Reference： [1] Journal of the American Chemical Society, 1990, vol. 112, # 19, p. 6936 - 6942

3
[ 672324-99-1 ]
[ 92053-25-3 ]

Yield	Reaction Conditions	Operation in experiment
33%	With potassium hydroxide In methanol at 25℃; for 84 h; Heating / reflux	To a solution of the compound prepared in Preparative Example 253, Step B (0.68 G, 3.0 MMOL) in MeOH (5 mL) was added a solution of KOH (0.68 G, 12.1 MMOL) in MeOH (5 mL). The mixture was stirred at reflux for 12h and rt for 72h whereupon the mixture was concentrated to dryness. The crude residue was suspended in EtOAc (50 mL) and was stirred vigorously for 30 min and was filtered. This procedure was repeated 2X more and the resultant filtrate was concentrated under reduced pressure to afford 128 mg (33percent) of a maroon/orange oil. M+H = 130. This material was used without purification in the subsequent coupling step.

Reference： [1] Patent: WO2004/22561, 2004, A1, . Location in patent: Page 116-117

4
[ 113304-84-0 ]
[ 92053-25-3 ]

Reference： [1] Journal of the American Chemical Society, 2003, vol. 125, # 31, p. 9306 - 9307
[2] Journal of the Chemical Society, Perkin Transactions 1, 2000, # 10, p. 1513 - 1518
[3] Angewandte Chemie - International Edition, 2016, vol. 55, # 27, p. 7698 - 7701[4] Angew. Chem., 2016, vol. 128, p. 7829 - 7832,4

5
[ 5211-23-4 ]
[ 92053-25-3 ]

Reference： [1] Journal of the American Chemical Society, 1990, vol. 112, # 19, p. 6936 - 6942

6
[ 1148-11-4 ]
[ 92053-25-3 ]

Reference： [1] Journal of the American Chemical Society, 1990, vol. 112, # 19, p. 6936 - 6942

7
[ 77581-28-3 ]
[ 74-88-4 ]
[ 92053-25-3 ]

Reference： [1] Organic and Biomolecular Chemistry, 2017, vol. 15, # 11, p. 2422 - 2435

8
[ 59936-29-7 ]
[ 92053-25-3 ]

Reference： [1] Organic Letters, 2015, vol. 17, # 9, p. 2242 - 2245

9
[ 147-85-3 ]
[ 92053-25-3 ]

Reference： [1] Angewandte Chemie - International Edition, 2016, vol. 55, # 27, p. 7698 - 7701[2] Angew. Chem., 2016, vol. 128, p. 7829 - 7832,4

10
[ 92053-25-3 ]
[ 118971-00-9 ]

Reference： [1] Journal of the American Chemical Society, 1990, vol. 112, # 19, p. 6936 - 6942

[ 92053-25-3 ] Synthesis Path-Downstream 1~73

1
[ 51207-68-2 ]
[ 92053-25-3 ]

Reference： [1]Journal of the American Chemical Society,1990,vol. 112,p. 6936 - 6942

2
[ 118970-92-6 ]
[ 92053-25-3 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogen; acetic acid;Pearlman's catalist; In methanol; at 20℃; for 24h;	Methylmagnesium chloride, 3.0m solution in tetrahydrofuran (24 ml, 71 mmol) was slowly injected into a solution of (S)-methyl l-benzylpyrrolidine-2-carboxylate (3.87 g, 18 mmol) in dry THF (50 mL) at 0 0C. The reaction mixture was stirred at that temperature for 3.5 h. The reaction was quenched with saturated NH4Cl and extracted with EtOAc (3x). The combined organic layers were washed with water and brine, dried (Na2SO4) and concentrated. The residue was chromatographed through a Redi-Sep pre-packed silica gel column (120 g), eluting with a gradient of 0% to 50% EtOAc in hexane, to provide (S)-2-(l-benzylpyrrolidin-2- yl)propan-2-ol as clear oil. [00290] To a solution of (S)-2-(l-benzylpyrrolidin-2-yl)propan-2-ol (1.38 g, 6.29 mmol) in MeOH (50 mL) was added palladium hydroxide, 20 wt % pd (dry basis) on carbon, wet, degussa type elOl ne/w (230 mg, 1.64 mmol) and acetic acid glacial (690 mul, 12.0 mmol). The reaction mixture was stirred at RT under 1 atm of H2 for 24 h.The reaction mixture was filtered through a pad of celite and washed with MeOH. The solvent was evaporated and the residue was partitioned between 2 N NaOH and EtOAc. The aqueous layer was extracted with EtOAc (2x) and the combined organic layer was dried (Na2SO4) and concentrated. The crude product was chromatographed through a Redi-Sep pre-packed silica gel column (40 g), eluting with a gradient of 50% to 100% MeOH in EtOAc, to provide (S)-2-(pyrrolidin-2-yl)propan-2-ol as an orange oil.

Reference： [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 1513 - 1518
[2]Bulletin des Societes Chimiques Belges,1988,vol. 97,p. 691 - 704
[3]Journal of the American Chemical Society,2003,vol. 125,p. 9306 - 9307
[4]Angewandte Chemie - International Edition,2007,vol. 46,p. 8431 - 8435
[5]Patent: WO2010/57121,2010,A1 .Location in patent: Page/Page column 91-92
[6]Angewandte Chemie - International Edition,2016,vol. 55,p. 7698 - 7701
Angew. Chem.,2016,vol. 128,p. 7829 - 7832,4

3
[ 92053-25-3 ]
[ 109-94-4 ]
[ 129149-57-1 ]

Reference： [1]Journal of the American Chemical Society,1990,vol. 112,p. 6936 - 6942

4
[ 92053-25-3 ]
[ 123-62-6 ]
[ 92053-21-9 ]

Reference： [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 1513 - 1518

5
[ 49566-72-5 ]
[ 92053-25-3 ]
[ 592526-98-2 ]

Reference： [1]Journal of the American Chemical Society,2003,vol. 125,p. 9306 - 9307

6
[ 108869-37-0 ]
[ 92053-25-3 ]
(S)-2-(1-hydroxy-1-methyl)ethyl-1-{(Rp)-[2.2]paracyclophane-4-carbonyl}pyrrolidine [ No CAS ]
(S)-2-(1-hydroxy-1-methyl)ethyl-1-{(Sp)-[2.2]paracyclophane-4-carbonyl}pyrrolidine [ No CAS ]

Reference： [1]Tetrahedron Asymmetry,2006,vol. 17,p. 2847 - 2856

7
[ 92053-25-3 ]
(Sp)-[2.2]paracyclophane-4-carbonyl chloride [ No CAS ]
(S)-2-(1-hydroxy-1-methyl)ethyl-1-{(Sp)-[2.2]paracyclophane-4-carbonyl}pyrrolidine [ No CAS ]

Reference： [1]Tetrahedron Asymmetry,2006,vol. 17,p. 2847 - 2856

8
[ 583-55-1 ]
[ 92053-25-3 ]
C₂H₄H₂C₁₁H₁₁NO [ No CAS ]
C₂H₄H₂C₁₁H₁₂NBrO [ No CAS ]

Reference： [1]Tetrahedron Letters,2007,vol. 48,p. 1703 - 1706

9
[ 92053-25-3 ]
C₂H₄H₂C₁₁H₁₁NOC₁₂H₉P [ No CAS ]

Reference： [1]Tetrahedron Letters,2007,vol. 48,p. 1703 - 1706

10
[ 2577-48-2 ]
4-MeO-C₆H₄CH₂-X [ No CAS ]
[ 92053-25-3 ]

Reference： [1]Journal of the American Chemical Society,2003,vol. 125,p. 9306 - 9307

11
[ 92053-25-3 ]
2-[1-(5,5-dimethyl-4,5-dihydro-1<i>H</i>-pyrazol-3-ylmethyl)-pyrrolidin-2-yl]-propan-2-ol [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2003,vol. 125,p. 9306 - 9307

12
[ 92053-25-3 ]
2-[1-(1-benzyl-5,5-dimethyl-4,5-dihydro-1<i>H</i>-pyrazol-3-ylmethyl)-pyrrolidin-2-yl]-propan-2-ol [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2003,vol. 125,p. 9306 - 9307

13
[ 113304-84-0 ]
[ 92053-25-3 ]

Reference： [1]Journal of the American Chemical Society,2003,vol. 125,p. 9306 - 9307
[2]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 1513 - 1518
[3]Angewandte Chemie - International Edition,2016,vol. 55,p. 7698 - 7701
Angew. Chem.,2016,vol. 128,p. 7829 - 7832,4

14
[ 2577-48-2 ]
prenyl-X [ No CAS ]
[ 92053-25-3 ]

Reference： [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 1513 - 1518

15
[ 92053-25-3 ]
(2R,3S)-3-Hydroxy-1-[(S)-2-(1-hydroxy-1-methyl-ethyl)-pyrrolidin-1-yl]-2-methyl-3-phenyl-propan-1-one [ No CAS ]

Reference： [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 1513 - 1518

16
[ 92053-25-3 ]
(2R,3R)-3-Hydroxy-1-[(S)-2-(1-hydroxy-1-methyl-ethyl)-pyrrolidin-1-yl]-2-methyl-3-phenyl-propan-1-one [ No CAS ]

Reference： [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 1513 - 1518

17
[ 92053-25-3 ]
(2S,3S)-3-Hydroxy-1-[(S)-2-(1-hydroxy-1-methyl-ethyl)-pyrrolidin-1-yl]-2-methyl-3-phenyl-propan-1-one [ No CAS ]

Reference： [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 1513 - 1518
[2]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 1513 - 1518

18
[ 92053-25-3 ]
(2S,3R)-3-Hydroxy-1-[(S)-2-(1-hydroxy-1-methyl-ethyl)-pyrrolidin-1-yl]-2-methyl-3-phenyl-propan-1-one [ No CAS ]

Reference： [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 1513 - 1518
[2]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 1513 - 1518

19
[ 92053-25-3 ]
[ 118971-00-9 ]

Reference： [1]Journal of the American Chemical Society,1990,vol. 112,p. 6936 - 6942

20
[ 92053-25-3 ]
[ 129173-93-9 ]

Reference： [1]Journal of the American Chemical Society,1990,vol. 112,p. 6936 - 6942

21
[ 5211-23-4 ]
[ 92053-25-3 ]

Reference： [1]Journal of the American Chemical Society,1990,vol. 112,p. 6936 - 6942

22
[ 1148-11-4 ]
[ 92053-25-3 ]

Reference： [1]Journal of the American Chemical Society,1990,vol. 112,p. 6936 - 6942

23
[ 672324-99-1 ]
[ 92053-25-3 ]

Yield	Reaction Conditions	Operation in experiment
33%	With potassium hydroxide; In methanol; at 25℃; for 84h;Heating / reflux;	To a solution of the compound prepared in Preparative Example 253, Step B (0.68 G, 3.0 MMOL) in MeOH (5 mL) was added a solution of KOH (0.68 G, 12.1 MMOL) in MeOH (5 mL). The mixture was stirred at reflux for 12h and rt for 72h whereupon the mixture was concentrated to dryness. The crude residue was suspended in EtOAc (50 mL) and was stirred vigorously for 30 min and was filtered. This procedure was repeated 2X more and the resultant filtrate was concentrated under reduced pressure to afford 128 mg (33%) of a maroon/orange oil. M+H = 130. This material was used without purification in the subsequent coupling step.

Reference： [1]Patent: WO2004/22561,2004,A1 .Location in patent: Page 116-117

Yield	Reaction Conditions	Operation in experiment
98%		B. (S)-2-Pyrrolidin-2-yl-propan-2-ol A mixture of (S)-2-(1-hydroxy-1-methyl-ethyl)-pyrrolidine-1-carboxylic acid benzyl ester (0.727 g, 2.76 mmol) and Pd/C (10%, 72 mg) in EtOH was shaken with H2 in a Parr bottle under 50 psi. After 12 h the reaction mixture was filtered through celite. HCl (9 mmol, 1 N in Et2O) was added to the filtrate, the filtrate was then concentrated to give a white solid (350 mg, 98%).
	With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 120℃; for 16h;	General procedure: To a solution of 737B (2.0 g, 8.29 mmol) and (2S,6R)-2,6-dimethylmorpholine (1.050 g, 9.12 mmol) in N-methyl-2-pyrrolidone (15 mL) was added N,N-diisopropylethylamine (4.34 mL, 24.87 mmol). After stirring at 120 C. for 16 hours, the reaction mixture was cooled to room temperature and diluted with diethyl ether. The organic layer was washed with 10% aq. AcOH solution, 10% NaHCO3 solution, and brine. The combined organics were dried over Na2SO4, filtered, and concentrated under reduced pressure. Purification via flash chromatography gave 737C (orange solid, 2.3 g, 6.26 mmol, 75% yield). LC-MS Anal. Calc'd. for C17H24N2O5, 336.383. found [M+H] 337.4. Tr=2.969 min (Method BE).

25
[ 380235-85-8 ]
[ 92053-25-3 ]
(2S)-[2-(1-Hydroxy-1-methyl-ethyl)-pyrrolidin-1-yl]-[7-(2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-methanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		C. (2S)-[2-(1-Hydroxy-1-methyl-ethyl)-pyrrolidin-1-yl]-[7-(2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-methanone The title compound was prepared from 7-(2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridine-2-carboxylic acid and (S)-2-pyrrolidin-2-yl-propan-2-ol by a procedure analogous to Example 21B. MS: 435.3; HPLC Rf: 4.134 min.; HPLC purity 95%.

Reference： [1]Patent: US2002/42409,2002,A1

26
[ 75-77-4 ]
[ 92053-25-3 ]
[ 917773-68-3 ]

Reference： [1]Angewandte Chemie - International Edition,2007,vol. 46,p. 8431 - 8435

27
[ 92053-25-3 ]
[ 866219-14-9 ]

Yield	Reaction Conditions	Operation in experiment
	With 4-methyl-morpholine; phosphorus trichloride; In toluene; at 0 - 20℃; for 1.5h;	The WV-CA-090 (2.00 g, 15.48 mmol) was dried by azeotropic distillation on a rotary evaporator with toluene (20 mL*3). To a solution of PC13 (2.13 g, 15.48 mmol) in toluene (20.00 mL) was added a solution of WV-CA-090 (2.00 g, 15.48 mmol) and 4- methylmorpholine (3.13 g, 30.96 mmol) in toluene (20.00 mL) at 0 C. The mixture was stirred at 15 20 C for 1.5 hr. The Phosphoryl chloride was not suitable for detection and no monitoring. The resulting mixture was filtered (flushed with Ar) and concentrated to afford the compound 1 (2.10 g, crude) was used into the next step without further purification.

Reference： [1]Angewandte Chemie - International Edition,2009,vol. 48,p. 496 - 499
[2]Patent: WO2018/237194,2018,A1 .Location in patent: Paragraph 001339; 001340; 001341; 001342

28
[ 92053-25-3 ]
[ 98-88-4 ]
[ 1173700-45-2 ]

Reference： [1]Angewandte Chemie - International Edition,2009,vol. 48,p. 496 - 499

29
[ 7294-50-0 ]
[ 92053-25-3 ]
[ 1360563-86-5 ]

Reference： [1]ARKIVOC,2012,vol. 2012,p. 5 - 19

30
[ 92053-25-3 ]
[ 67-64-1 ]
[ 1429301-88-1 ]

Reference： [1]Journal of Organic Chemistry,2013,vol. 78,p. 3592 - 3615

31
(S)-tert-butyl 2-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate [ No CAS ]
[ 92053-25-3 ]

Yield	Reaction Conditions	Operation in experiment
69.02%	With hydrogenchloride; In ethyl acetate; at 0 - 25℃; for 2h;	To a solution of compound 2 (36.00 g, 156.99 mmol) in EtOAc (30 mL) was added HC1/EtOAc (360.00 mL) at 0 C. The mixture was stirred at 0 - 25 C for 2 hr. TLC indicated compound 2 was consumed and one new spot formed. The reaction mixture was concentrated under reduced pressure to remove solvent at 30-3 5 C, then to the residue was added H20 (5 mL) and sat. Na2CO3 aq. until pH = 11. The combined organic layers were washed with dichloromethane (300 mL*6), dried over Na2SO4, filtered and concentrated under reduced pressure to give a residue. WV-CA-090 was obtained as a yellow solid (14.00 g, 69.02%). ?HNMR(400 MHz, CHLOROFORM-d) = 3.05 -2.84 (m, 3H), 1.81 - 1.52 (m, 4H),1.13 (s, 3H), 1.09(s, 3H). ?3CNMR(101 IVIFIz, CHLOROFORIVI-d) E70.31, 66.91, 46.95,28.67, 26.36, 26.08, 25.10. LCMS: (M+H+): 130.1. TLC (Plate 1: Petroleum ether: Ethyl acetate = 3:1)Rf= 0.

Reference： [1]Tetrahedron,2019,vol. 75
[2]Organic Letters,2015,vol. 17,p. 2242 - 2245
[3]Patent: WO2018/237194,2018,A1 .Location in patent: Paragraph 001333; 001334; 001337; 001338
[4]Chemical Communications,2015,vol. 51,p. 5751 - 5753

32
[ 92053-25-3 ]
C₃₇H₄₃NO₂ [ No CAS ]

Reference： [1]Chemical Communications,2015,vol. 51,p. 5751 - 5753

33
[ 92053-25-3 ]
2-[(2′-methoxybiphenyl-2-ylimino)methyl]-4-tert-butyl-6-tritylphenol [ No CAS ]
C₃₇H₄₃NO₃ [ No CAS ]

Reference： [1]Chemical Communications,2015,vol. 51,p. 5751 - 5753

34
[ 59936-29-7 ]
[ 92053-25-3 ]

Reference： [1]Organic Letters,2015,vol. 17,p. 2242 - 2245
[2]Patent: WO2018/237194,2018,A1

35
[ 37942-07-7 ]
[ 92053-25-3 ]
2,4-di-tert-butyl-6-(((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)methyl)phenol [ No CAS ]

Reference： [1]Organic Letters,2015,vol. 17,p. 2242 - 2245

36
[ 147-85-3 ]
[ 92053-25-3 ]

Reference： [1]Angewandte Chemie - International Edition,2016,vol. 55,p. 7698 - 7701
Angew. Chem.,2016,vol. 128,p. 7829 - 7832,4

37
[ 27607-77-8 ]
[ 92053-25-3 ]
[ 917773-68-3 ]

Reference： [1]Angewandte Chemie - International Edition,2016,vol. 55,p. 7698 - 7701
Angew. Chem.,2016,vol. 128,p. 7829 - 7832,4

38
methyl 3-(4-fluoro-3-nitrophenyl)butanoate [ No CAS ]
[ 92053-25-3 ]
methyl 3-(4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)-3-nitrophenyl)butanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
89%	With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 120℃; for 16h;	To a solution of 737B (2.0 g, 8.29 mmol) and <strong>[92053-25-3](S)-2-(pyrrolidin-2-yl)propan-2-ol</strong> (1.285 g, 9.95 mmol) in N-methyl-2-pyrrolidone (15 mL) was added N,N-diisopropylethylamine (4.34 mL, 24.87 mmol). After stirring at 120 C. for 16 hours, the reaction mixture was cooled to room temperature and diluted with diethyl ether. The organic layer was washed with 10% aq. AcOH solution, 10% NaHCO3 solution, brine, dried over Na2SO4 and was concentrated under reduced pressure to afford a residue. The residue was purified via flash silica gel column chromatography (0-100% ethyl acetate in pet ether as eluent) to afford 797A (orange solid, 2.65 g, 7.38 mmol, 89% yield). LC-MS Anal. Calc'd. for C18H26N2O5, 350.409. found [M+H] 351.2. Tr=2.826 min (Method U).

Reference： [1]Patent: US2016/289171,2016,A1 .Location in patent: Paragraph 1696

39
[ 92053-25-3 ]
3-(3-((4-cyanophenyl)amino)-4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)phenyl)butanoic acid [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1

40
[ 92053-25-3 ]
3-(4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)-3-(3-(p-tolyl)ureido)phenyl)pentanoic acid [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1
[2]Patent: US2016/289171,2016,A1

41
[ 92053-25-3 ]
3-(4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)-3-(3-(p-tolyl)ureido)phenyl)pentanoic acid [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1
[2]Patent: US2016/289171,2016,A1

42
[ 92053-25-3 ]
(S)-2-(1-(4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-2-nitrophenyl)pyrrolidin-2-yl)propan-2-ol [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1

43
[ 92053-25-3 ]
methyl 3-(4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)-3-nitrophenyl)pentanoate [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1

44
[ 92053-25-3 ]
methyl 3-(3-amino-4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)phenyl)pentanoate [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1
[2]Patent: US2016/289171,2016,A1

45
[ 92053-25-3 ]
methyl 3-(4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)-3-(3-(p-tolyl)ureido)phenyl)pentanoate [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1
[2]Patent: US2016/289171,2016,A1

46
[ 92053-25-3 ]
3-(4-((S)-2-(2-fluoropropan-2-yl)pyrrolidin-1-yl)-3-(3-(p-tolyl)ureido)phenyl)pentanoic acid [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1

47
[ 92053-25-3 ]
(S)-1-(4-bromo-2-nitrophenyl)-2-(2-fluoropropan-2-yl)pyrrolidine [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1

48
[ 92053-25-3 ]
(S)-1-(4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-2-nitrophenyl)-2-(2-fluoropropan-2-yl)pyrrolidine [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1

49
[ 92053-25-3 ]
methyl 3-(4-((S)-2-(2-fluoropropan-2-yl)pyrrolidin-1-yl)-3-nitrophenyl)pentanoate [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1

50
[ 92053-25-3 ]
C₁₉H₂₉FN₂O₂ [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1

51
[ 92053-25-3 ]
methyl 3-(4-((S)-2-(2-fluoropropan-2-yl)pyrrolidin-1-yl)-3-(3-(p-tolyl)ureido)phenyl)pentanoate [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1

52
[ 92053-25-3 ]
3-(3-((4-chlorophenyl)amino)-4-((S)-2-(2-fluoropropan-2-yl)pyrrolidin-1-yl)phenyl)pentanoic acid [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1

53
[ 92053-25-3 ]
methyl 3-(3-((4-chlorophenyl)amino)-4-((S)-2-(2-fluoropropan-2-yl)pyrrolidin-1-yl)phenyl)pentanoate [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1

54
[ 92053-25-3 ]
methyl 3-(3-amino-4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)phenyl)butanoate [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1

55
[ 92053-25-3 ]
methyl 3-(3-((4-cyanophenyl)amino)-2-((2-hydroxypropan-2-yl)pyrrolidin-1-yl)phenyl)butanoate [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1

56
[ 92053-25-3 ]
3-(3-(3-(4-ethoxyphenyl)ureido)-4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)phenyl)pentanoic acid [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1
[2]Patent: US2016/289171,2016,A1

57
[ 92053-25-3 ]
methyl 3-(3-(3-(4-ethoxyphenyl)ureido)-4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)phenyl)pentanoate [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1
[2]Patent: US2016/289171,2016,A1

58
[ 92053-25-3 ]
3-(3-((4-ethoxyphenyl)amino)-4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)phenyl)pentanoic acid [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1
[2]Patent: US2016/289171,2016,A1

59
[ 92053-25-3 ]
methyl 3-(3-((4-ethoxyphenyl)amino)-4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)phenyl)pentanoate [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1
[2]Patent: US2016/289171,2016,A1

60
[ 92053-25-3 ]
methyl 3-(3-amino-4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)phenyl)pentanoate [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1
[2]Patent: US2016/289171,2016,A1

61
[ 92053-25-3 ]
methyl 3-(3-amino-4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)phenyl)pentanoate [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1
[2]Patent: US2016/289171,2016,A1

62
[ 92053-25-3 ]
methyl 3-(4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)-3-(3-(p-tolyl)ureido)phenyl)pentanoate [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1
[2]Patent: US2016/289171,2016,A1

63
[ 92053-25-3 ]
C₁₉H₂₉FN₂O₂ [ No CAS ]
C₁₉H₂₉FN₂O₂ [ No CAS ]

Reference： [1]Patent: US2016/289171,2016,A1

64
[ 364-73-8 ]
[ 92053-25-3 ]
(S)-2-(1-(4-bromo-2-nitrophenyl)pyrrolidin-2-yl)propan-2-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
94%	With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 150℃; for 18h;	To a solution of 4-bromo-1-fluoro-2-nitrobenzene (5.0 g, 22.73 mmol) and 767C (2.94 g, 22.73 mmol) in N-methyl-2-pyrrolidone (25 mL) was added N,N-diisopropylethylamine (11.91 mL, 68.2 mmol). After stirring at 150 C. for 18 hours, the reaction mixture was cooled to room temperature and diluted with diethyl ether. The organic layer was washed with 10% aq. AcOH solution, 10% NaHCO3 solution, and brine. The combined organics were dried over Na2SO4, filtered, and concentrated under reduced pressure to afford a residue. The residue was purified via flash silica gel column chromatography (0-100% ethyl acetate in pet ether as eluent) to afford 767D (orange liquid, 7.0 g, 21.26 mmol, 94% yield). LC-MS Anal. Calc'd. for C13H17BrN2O3 329.190. found [M+2] 331.2. Tr=2.688 min (Method U).

Reference： [1]Patent: US2016/289171,2016,A1 .Location in patent: Paragraph 1624

65
methyl 3-(4-fluoro-3-nitrophenyl)pentanoate [ No CAS ]
[ 92053-25-3 ]
methyl 3-(4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)-3-nitrophenyl)pentanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69.2%	With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 120℃;	To a solution of 810C (1.5 g, 5.88 mmol) in NMP (10 mL) was added DIPEA (3.08 mL, 17.63 mmol), followed by <strong>[92053-25-3](S)-2-(pyrrolidin-2-yl)propan-2-ol</strong> (0.911 g, 7.05 mmol). Reaction mixture was heated to 120 C. and was stirred overnight. LCMS indicated completion of reaction. The reaction mixture was cooled to room temperature and diluted with diethyl ether. The organic layer was washed with 10% aq. AcOH solution, 10% NaHCO3 solution and brine. The combined organics were dried over Na2SO4 and concentrated under reduced pressure to afford a residue. Purification via flash chromatography gave 810D (orange liquid, 1.5 g, 4.07 mmol, 69.2% yield). LC-MS Anal. Calc'd. C19H28N2O5 [M+H] 365.2, Tr=2.994 min (Method U).

Reference： [1]Patent: US2016/289171,2016,A1 .Location in patent: Paragraph 1720

66
methyl 3-(4-fluoro-3-nitrophenyl)-3-methylbutanoate [ No CAS ]
[ 92053-25-3 ]
(S)-methyl 3-(4-(2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)-3-nitrophenyl)-3-methylbutanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 120℃; for 16h;	To a solution of 1F (0.65 g, 2.55 mmol) and <strong>[92053-25-3](S)-2-(pyrrolidin-2-yl)propan-2-ol</strong> (0.395 g, 3.06 mmol) in N-methyl-2-pyrrolidine (8.0 mL) was added N,N-diisopropylethylamine (1.334 mL, 7.64 mmol). After stirring at 120 C. for 16 hours, the reaction mixture was cooled to room temperature and diluted with diethyl ether, the organic layer was washed with 10% aq. AcOH solution, 10% NaHCO3 solution and brine. The combined organics were dried over Na2SO4 and concentrated. The crude product was chromatographed on silica gel (eluting with EtOAc/hexane) to afford 807A (orange solid, 0.8 g, 2.037 mmol, 80% yield). LC-MS Anal. Calc'd. for C19H28N2O5, 364.436. found [M+H] 365.2, Tr=2.977 min (Method U).

Reference： [1]Patent: US2016/289171,2016,A1 .Location in patent: Paragraph 1710

67
[ 30148-21-1 ]
[ 92053-25-3 ]
[ 1441046-95-2 ]
(R)-[2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl](1-methyl-1Himidazol-2-yl)methanone [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2017,vol. 15,p. 2422 - 2435

68
[ 77581-28-3 ]
[ 74-88-4 ]
[ 92053-25-3 ]

Reference： [1]Organic and Biomolecular Chemistry,2017,vol. 15,p. 2422 - 2435

69
[ 92053-25-3 ]
C₄₁H₄₉N₄O₈P [ No CAS ]

Reference： [1]Patent: WO2018/237194,2018,A1

70
1-((R)-1-(2,4-dichlorophenyl)ethyl)-6-(5-methyl-4-oxocyclohex-1-en-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile [ No CAS ]
[ 92053-25-3 ]
[ 76-05-1 ]
1-((R)-1-(2,4-dichlorophenyl)ethyl)-6-(4-((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)-5-methylcyclohex-1-en-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile 2,2,2-trifluoroacetate [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2019,vol. 62,p. 6190 - 6213

71
[ 75-16-1 ]
[ 59936-29-7 ]
[ 92053-25-3 ]

Reference： [1]Tetrahedron,2019,vol. 75

72
[ 92053-25-3 ]
(1R,1'R,2S,2'S)-1,1'-(propane-1,3-diyl)bis(2-(2-hydroxypropan-2-yl)pyrrolidine 1-oxide) [ No CAS ]

Reference： [1]Tetrahedron,2019,vol. 75

73
[ 92053-25-3 ]
[ 109-64-8 ]
C₁₇H₃₄N₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
93%	With potassium carbonate; In acetonitrile; at 95℃;	General procedure: Amino alcohol 4b (1.07g, 8.3mmol) was added to a 100mL round-bottomed flask containing 50mL acetonitrile, then 1,3-dibromopropane (0.83g, 4.2mmol) and potassium carbonate (3.50g, 2.5mmol) was slowly added portionwise to the flask over 10min. The mixture was stirred overnight at 95C, then cooled to room temperature. The solvent was removed in vacuo, water (20mL) was added to the residue, and the mixture was extracted with ethyl acetate (3×10mL). The combined organic phase was dried over Na2SO4, filtered and concentrated. The obtained amino alcohol 5b was used without further purification. (0018) To a solution of amino alcohol 5b (0.95g, 3.2mmol) in 15mL dichloromethane, was added m-chloroperoxybenzoic acid (1.61g, 7.0mmol). The mixture was stirred at room temperature for 12h, and the solvent was removed in vacuo to give the crude product. Compound 1b was obtained in 80% (1.02g) after column chromatography through silica gel (ethyl acetate as eluent).

Reference： [1]Tetrahedron,2019,vol. 75

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
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P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 92053-25-3 ] {[proInfo.proName]}

Quality Control of [ 92053-25-3 ]

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Safety of [ 92053-25-3 ]

Application In Synthesis of [ 92053-25-3 ]

[ 92053-25-3 ] Synthesis Path-Upstream 1~10

[ 92053-25-3 ] Synthesis Path-Downstream 1~73

Related Functional Groups of [ 92053-25-3 ]

Alcohols

Related Parent Nucleus of [ 92053-25-3 ]

Aliphatic Heterocycles

Pyrrolidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 92053-25-3 ]

Related Parent Nucleus of
[ 92053-25-3 ]