Name: Nilotinib monohydrochloride monohydrate | AMN107 monohydrochloride monohydrate; Nilotinib (hydrochloride hydrate)
Brand: Ambeed
SKU: A191440

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CAS No. :	923288-90-8
Formula :	C₂₈H₂₅ClF₃N₇O₂
M.W :	583.99
SMILES Code :	O=C(NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1)C3=CC=C(C)C(NC4=NC=CC(C5=CC=CN=C5)=N4)=C3.[H]Cl.[H]O[H]
Synonyms :	AMN107 monohydrochloride monohydrate; Nilotinib (hydrochloride hydrate); AMN-107 hydrochloride monohydrate
MDL No. :	MFCD18251359
InChI Key :	YCBPQSYLYYBPDW-UHFFFAOYSA-N
Pubchem ID :	16757572

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Ba/F3 cells	0.3–10 µM		To investigate the inhibitory effects of GNF-5 in combination with nilotinib on the proliferation of T315I Bcr-Abl Ba/F3 cells, showing synergistic effects.	PMC2901986
8093 lymphoblastic leukemia cells	200 nM	24 hours	To evaluate the killing effect of nilotinib on lymphoblastic leukemia cells, results showed that 200 nM nilotinib reduced cell viability to 18% within 24 hours.	PMC2169263
B-1 lymphoblastic leukemia cells	100 nM	24 hours	To compare the killing effect of nilotinib and imatinib on B-1 cells, results showed that 100 nM nilotinib significantly reduced cell viability within 24 hours.	PMC2169263
B-2 lymphoblastic leukemia cells	200 nM	24 hours	To compare the killing effect of nilotinib and imatinib on B-2 cells, results showed that 200 nM nilotinib significantly reduced cell viability within 24 hours.	PMC2169263
D04 cells	100nM	3 hours	To investigate the effect of nilotinib on the MEK/ERK pathway, results showed that nilotinib at 100nM significantly activated MEK and ERK phosphorylation.	PMC3951999
SW620 cells	1μM	3 hours	To investigate the effect of nilotinib on the MEK/ERK pathway in SW620 cells, results showed that nilotinib at 1μM activated MEK and ERK phosphorylation.	PMC3951999
Panc1 cells	1μM	3 hours	To investigate the effect of nilotinib on the MEK/ERK pathway in Panc1 cells, results showed that nilotinib at 1μM activated MEK and ERK phosphorylation.	PMC3951999
H460 cells	1μM	3 hours	To investigate the effect of nilotinib on the MEK/ERK pathway in H460 cells, results showed that nilotinib at 1μM activated MEK and ERK phosphorylation.	PMC3951999
BCR-ABLT315I Ba/F3 cells	1μM	4 days	To investigate the effect of nilotinib on the proliferation of BCR-ABLT315I Ba/F3 cells, results showed that nilotinib in combination with the MEK inhibitor PD184352 significantly inhibited cell proliferation and induced apoptosis.	PMC3951999
Nonparenchymal cells (NPCs)	1 μM	2 hours	Nilotinib inhibited CpG-mediated activation of p38 MAPK and cytokine production in NPCs.	PMC3437237
HCC cells	1–20μM	48 or 72 hours	Nilotinib inhibited HCC cell growth	PMC7387191

mice	T315I Bcr-Abl bone marrow transplantation model	orally	20 mg/kg	Once daily for 20 days	To evaluate the efficacy of GNF-5 in combination with nilotinib in a T315I Bcr-Abl mouse model, showing that the combination significantly prolonged survival and inhibited tumor growth.	PMC2901986
mice	P190 Bcr/Abl lymphoblastic leukemia model	oral	75 mg/kg GNF-5 and 50 mg/kg nilotinib	twice daily until day 50 post-transplantation	To evaluate the therapeutic effect of nilotinib on P190 Bcr/Abl lymphoblastic leukemia in vivo, results showed that nilotinib significantly prolonged the survival of mice.	PMC2169263
Nude mice	BCR-ABLT315I Ba/F3 xenograft model	Oral	75 mg/kg	once daily for 50 days	To investigate the effect of nilotinib in combination with the MEK inhibitor PD184352 on BCR-ABLT315I xenografts, results showed that the combination significantly inhibited tumor growth.	PMC3951999
Mice	Liver ischemia/reperfusion injury model	Oral	10 mg/kg	Every other day for 30 days	Nilotinib significantly reduced serum ALT levels, histologic injury, and apoptosis following liver ischemia/reperfusion injury, and attenuated the inflammatory response by inhibiting JNK and p38 MAPK activation.	PMC3437237
Mice	MET/CAT-induced HCC model	Oral	25 mg/kg	Daily, for the duration of the treatment	Nilotinib inhibited HCC tumor growth and prolonged survival in mice	PMC7387191

NCT01223898	Chronic Myeloid Leukemia	PHASE1	COMPLETED	2025-12-13	Novartis Investigative Site, F... More >>rankfurt/M, 60590, Germany\|Novartis Investigative Site, Jena, 07740, Germany\|Novartis Investigative Site, Mannheim, 68167, Germany\|Novartis Investigative Site, Ulm, 89081, Germany\|Novartis Investigative Site, Glasgow, G12 0YN, United Kingdom Less <<
NCT01261429	Pigmented Villonodular Synovit... More >>is Less <<	PHASE2	COMPLETED	2025-04-13	Institut Bergonié, Bordeaux, F... More >>rance\|Centre Oscar Lambret, Lille, France\|Centre Léon Bérard, Lyon, France\|H?pital La Timone, Marseille, France\|Institut Paoli Calmettes, Marseille, France\|Institut Curie, Paris, France\|Institut Claudius Regaud, Toulouse, France\|Institut Gustave Roussy, Villejuif, France\|Istituto Nazionale dei Tumori, Milano, Italy\|Regina Elena National Cancer Institute, Roma, Italy\|Leiden University Medical Center, Leiden, Netherlands\|Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands\|Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland\|University College Hospital UCL Hospitals NHS Foundation Trust, London, United Kingdom\|Oxford Cancer Centre, Oxford, United Kingdom Less <<
NCT01275586	Neurofibromatosis\|NF1\|Neurofib... More >>romas Less <<	EARLY_PHASE1	COMPLETED	2025-10-16	Riley Hospital for Children, I... More >>ndianapolis, Indiana, 46202, United States Less <<

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 923288-90-8

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CAS No.: 923288-90-8

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