[ CAS No. 92638-81-8 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 92638-81-8
Chemical Structure| 92638-81-8
Structure of 92638-81-8

Quality Control of [ 92638-81-8 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 92638-81-8 ]

SDS

Product Details of [ 92638-81-8 ]

CAS No. :92638-81-8MDL No. :MFCD29919320
Formula :C25H17NBoiling Point :-
Linear Structure Formula :-InChI Key :GFOZRCASAHKFFT-UHFFFAOYSA-N
M.W :331.41Pubchem ID :13293439
Synonyms :

Computed Properties of [ 92638-81-8 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 92638-81-8 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 92638-81-8 ]

  • Downstream synthetic route of [ 92638-81-8 ]

[ 92638-81-8 ] Synthesis Path-Downstream   1~10

  • 1
  • C25H15BrO2S [ No CAS ]
  • [ 92638-81-8 ]
  • C50H31NO2S [ No CAS ]
YieldReaction ConditionsOperation in experiment
97% With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate; In toluene; at 110℃; for 24h;Inert atmosphere; Reflux; Under the protection of nitrogen, a 2-bromospirofluorene thioxanthene-10,10-dioxide 459 mg (1 mmol) prepared in Example 1 was added to a 100 mL two-port reactor equipped with a reflux tube,Spirofluorene acridine 331mg (1mmol),Palladium acetate 11mg (0.05mmol),10% of tri-tert-butylphosphineToluene solution 0.3mL (0.1mmol),10mL of toluene,Heat to 110 C and stir under reflux for 24 hours,After the reaction, the organic solvent was distilled off, a large amount of water and methylene chloride were added for extraction,The organic phase after extraction is dried over anhydrous sodium sulfate, filtered, and then the organic liquid phase is distilled off,Get crude products;The crude product was purified by column chromatography with petroleum ether and methylene chloride,Then dried, purified by sublimation at 300 White powder of 2-spirofluoracridinyl-spirofluorene thioxanthene-10,10-dioxide was obtained.The yield of the 2-spirofluoracridyl-spirofluorene thioxanthene-10,10-dioxide is 689 mg,The yield was 97%.
  • 2
  • C18H6Br2Cl2O2 [ No CAS ]
  • [ 92638-81-8 ]
  • C68H38Cl2N2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% 9.7 g (20 mmol) of compound 3-A, 100 mmol of sodium tert-butoxide, 40 mmol of 10H-spiro[acridin-9,9'-fluorene] and 200 mL of toluene were mixed and refluxed to heat for 30 minutes. Then, 0.2 mmol of tetrakistriphenylphosphinepalladium was added, followed by stirring for 3 hours in a reflux state. After the reaction, the reaction solution was returned to room temperature, extracted with water, and the organic layer was recrystallized twice with chloroform to obtain 15 g of compound 4-H (yield 76%).
  • 3
  • C22H8Br2Cl2O2 [ No CAS ]
  • [ 92638-81-8 ]
  • C72H40Cl2N2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
79% 10.7 g (20 mmol) of Compound 3-B, 100 mmol of sodium-t-butoxide, 40 mmol of 10H-spiro [acridin-9,9'-fluorene], and 200 mL of toluene were mixed, refluxed, heated for 30 minutes, and 0.2 mmol of tetrakistriphenylphosphinepalladium was added, followed by stirring for 3 hours in a reflux state. After the reaction, the reaction solution was returned to room temperature, extracted with water, and the organic layer was recrystallized twice with chloroform to give 16.4 g of compound 4-I (yield 79%).
  • 4
  • [ 92638-81-8 ]
  • [ 202865-85-8 ]
  • 10-(4-bromo-3-methylphenyl)-10H-spiro[acridine-9,9′-fluorene] [ No CAS ]
YieldReaction ConditionsOperation in experiment
54.5% With copper(l) iodide; trans-1,2-Diaminocyclohexane; sodium t-butanolate; In 1,4-dioxane; at 100℃;Inert atmosphere; A mixture of 10H-spiro[acridine-9,9?-fluorene] (1) (4.50 g,13.60 mmol), 1-bromo-4-iodo-2-methylbenzene (4.45 g, 15 mmol),copper iodide (260 mg, 0.1.36 mmol), (±)-trans-1,2-diaminocyclohexane(0.34 mL, 2.8 mmol) and sodium tert-butoxide (2.60 g,2.80 mmol) in 1,4-dioxane (15 mL) was refluxed overnight under a nitrogenatmosphere. The reaction mixture was then filtered through apad of silica and extracted with chlorofrom. The organic layer waswashed with water and brine, and dried over anhydrous sodium sulfate.The filtrate was concentrated in vacuo to give a crude mixture, which was purified by column chromatography (SiO2, CHCl3:hexane=1:4) toafford compound 3 (2.4 g, 54.5%) as a white solid.1H NMR (400 MHz, CDCl3) delta (ppm): 7.87 (d, J=8.3 Hz, 1H), 7.80(d, J=7.6 Hz, 2H), 7.43-7.32 (m, 5H), 7.28-7.18 (m, 3H), 6.97-6.89(m, 2H), 6.60-6.52 (m, 2H), 6.46-6.30 (m, 4H), 2.54 (s, 3H). 13C NMR(100 MHz, CDCl3) delta (ppm): 156.55, 141.22, 140.97, 140.20, 139.18,134.94, 133.41, 130.11, 128.35, 127.86, 127.58, 127.20, 125.73,124.77, 120.71, 119.89, 114.50, 56.72, 23.16.
  • 5
  • [ 92638-81-8 ]
  • (2-methyl-4-(10H-spiro[acridine-9,9′-fluoren]-10-yl)phenyl)boronic acid [ No CAS ]
  • 6
  • [ 92638-81-8 ]
  • (4-(10H-spiro[acridine-9,9′-fluoren]-10-yl)phenyl)boronic acid [ No CAS ]
  • 7
  • [ 92638-81-8 ]
  • 10-(4-(4,6-bis(4-methoxy-2-methylphenyl)-1,3,5-triazin-2-yl)-3-methylphenyl)-10H-spiro[acridine-9,9′-fluorene] [ No CAS ]
  • 8
  • [ 92638-81-8 ]
  • 10-(4-(4,6-di-o-tolyl-1,3,5-triazin-2-yl)-3-methylphenyl)-10H-spiro[acridine-9,9′-fluorene] [ No CAS ]
  • 9
  • [ 92638-81-8 ]
  • 10-(4-(4,6-bis(4-methoxyphenyl)-1,3,5-triazin-2-yl)phenyl)-10H-spiro[acridine-9,9′-fluorene] [ No CAS ]
  • 10
  • C25H20BrNO2 [ No CAS ]
  • [ 92638-81-8 ]
  • C50H36N2O2 [ No CAS ]
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