[ CAS No. 92642-09-6 ] {[proInfo.proName]}

Name: 92642-09-6|5,5'-Bis(bromomethyl)-2,2'-bipyridine|97%
Brand: Ambeed
SKU: A186985
Price: 35.0 USD
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Quality Control of [ 92642-09-6 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 92642-09-6 ]

CAS No. :	92642-09-6	MDL No. :	MFCD12031102
Formula :	C₁₂H₁₀Br₂N₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	OESAKGGTMNBXLT-UHFFFAOYSA-N
M.W :	342.03	Pubchem ID :	11056981
Synonyms :

Calculated chemistry of [ 92642-09-6 ]

Physicochemical Properties

Num. heavy atoms :	16
Num. arom. heavy atoms :	12
Fraction Csp3 :	0.17
Num. rotatable bonds :	3
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	73.14
TPSA :	25.78 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	Yes
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	Yes
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.54 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.81
Log Po/w (XLOGP3) :	2.6
Log Po/w (WLOGP) :	3.63
Log Po/w (MLOGP) :	2.28
Log Po/w (SILICOS-IT) :	4.47
Consensus Log Po/w :	3.16

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.96
Solubility :	0.0379 mg/ml ; 0.000111 mol/l
Class :	Soluble
Log S (Ali) :	-2.79
Solubility :	0.554 mg/ml ; 0.00162 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-6.65
Solubility :	0.0000767 mg/ml ; 0.000000224 mol/l
Class :	Poorly soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	0.0
Synthetic accessibility :	2.41

Safety of [ 92642-09-6 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P260-P264-P270-P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310-P362+P364-P405-P501	UN#:	3261
Hazard Statements:	H302+H312-H314	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 92642-09-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 92642-09-6 ]

[ 92642-09-6 ] Synthesis Path-Downstream 1~87

1
[ 110-91-8 ]
[ 92642-09-6 ]
5,5'-bis(morpholinomethyl)-2,2'-bipyridine [ No CAS ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1992,p. 1300 - 1302
[2]Chemical Communications,2018,vol. 54,p. 2421 - 2424
[3]Chemistry - A European Journal,2018,vol. 24,p. 10999 - 11007

2
[ 1122-58-3 ]
[ 92642-09-6 ]
C₂₆H₃₀N₆⁽²⁺⁾ [ No CAS ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1992,p. 1300 - 1302

3
[ 1762-34-1 ]
[ 92642-09-6 ]

Yield	Reaction Conditions	Operation in experiment
88%	With N-Bromosuccinimide;2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 18h;Reflux;	To a solution of 5 , 5 '-dimethyl-2,2'-bipyridine (10 mmol) in 50 . mL of 1 dry. I ''- 1 ' . . . . carbontetrachloride was added N-bromosuccinimide (20.5 mmol) and AIBN. The reactionI . i i . j . mixture was refluxed for 18h, cooled, filtered and the solvents were removed underI j 1 I . . reduced pressure to give the crude product which was further purified by recrystalliza'tion from CC14. 88%; mp. 188 C ; ; H NMR (CDC13 300 Hz) δ 4;53 (s, 4H , CH2Br), 7.79 (m, 2H, aromatic), 8.34 (m, 2H , aromatic), 8.61 (m, i 2H, aromatic). 13C NMR (CDCI3[ 75. I 1 : MHz) δ 29.43, 121.25, 133.28, 137.70, 149.27 , 155.19.
80 - 90%	With bromine;2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 18 - 20h;Heating / reflux;	To a solution of 5,5'-dimethyl-2,2'-bipyridine (10 mmol) in 50 mL of dry carbontetrachloride was added N-bromosuccinimide (20.5 mmol) and AIBN (Azobisisobutyronitrile). The reaction mixture was refluxed for 18-20 h., cooled, filtered and the solvents were removed under reduced pressure to give the crude product which was further purified by recrystallization from CCI4. Yield 80-90%; mp.188 0C; 1H NMR (CDCI3, 300 M Hz) δ 4.53 (s, 4H1 CH2Br), 7.79 (m, 2H, aromatic),8.34 (m, 2H, aromatic), 8.61 (m, 2H, aromatic). 13C NMR (CDCI3, 75 MHz) δ 29.43, 121.25, 133.28, 137.70, 149.27, 155.19.
73.1%	With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 80℃;	(1) 5,5'-dimethyl-2,2'-bipyridine (0.146 g, 0.8 mmol) with N-bromosuccinimide (0.313 g, 1.76 mmol) and azobisisobutyronitrile (0.328g, 2mmol) was heated to 80 C in carbon tetrachloride (20mL), the bromination reaction occurred, yielded 0.200 g of 5,5'-dibromomethyl-2,2'-bipyridine (0.585 mmol), Yield 73.1%;

54%

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 2h;Inert atmosphere; Reflux;

A solution of 1 (1 g, 5.42 mmol), NBS (1.93 g, 10.85 mmol), andAIBN (17 mg, 0.10 mmol) in CCl4 (50 mL) was refluxed under N2for 2 h and the precipitated succinimide was removed immediately from the hotmixture by filtration. The precipitate was washed with CCl4 and thecombined CCl4 phases were evaporated. The remaining solid wasdissolved in CH2Cl2 (100 mL) and extracted with 0.5 M Na2S2O3solution (2×150mL). The combined Na2S2O3 fractions wereextracted with CH2Cl2 (50 mL) and the combined CH2Cl2layers were dried (Na2SO4) and concentrated it.. Thecrude product was purified by column chromatography (silica gel, EtOAc/hexane,1:4) white powder. Yield is 54%,m.p 193-194C; 1H NMR (300 MHz, CDCl3) δ 8.67 (d, J= 3 Hz, 2H), 8.39 (d, J = 9 Hz, 2H), 7.87-7.84 (m, 2H), 4.53 (s, 4H).13CNMR (75 MHz, CDCl3) δC 149.78, 143.67, 131.82, 128.19,115.44, 23.74. ESI-MS( M+); 342.88

Reference： [1]Chemical Communications,2010,vol. 46,p. 6069 - 6071
[2]Patent: WO2011/33531,2011,A1 .Location in patent: Page/Page column 11; 14
[3]Inorganic Chemistry,2015,vol. 54,p. 4231 - 4242
[4]Patent: WO2009/84007,2009,A1 .Location in patent: Page/Page column 11
[5]Journal of the American Chemical Society,1997,vol. 119,p. 4622 - 4632
[6]Patent: CN110372754,2019,A .Location in patent: Paragraph 0052-0054
[7]Angewandte Chemie - International Edition,2021,vol. 60,p. 9474 - 9479
    Angew. Chem.,2021,vol. 133,p. 9560 - 9565,6
[8]Chemistry - A European Journal,2013,vol. 19,p. 13418 - 13427
[9]Inorganic Chemistry,2019,vol. 58,p. 5603 - 5616
[10]Green Chemistry,2019,vol. 21,p. 2295 - 2306
[11]Tetrahedron Letters,2015,vol. 56,p. 5209 - 5212
[12]Journal of the American Chemical Society,2009,vol. 131,p. 17620 - 17629
[13]Angewandte Chemie - International Edition,2013,vol. 52,p. 6464 - 6467
    Angew. Chem.,2013,vol. 125,p. 6592 - 6595,4
[14]Angewandte Chemie - International Edition,2020,vol. 59,p. 17125 - 17129
    Angewandte Chemie,2020,vol. 132,p. 17273 - 17277,5
[15]Inorganic Chemistry,2013,vol. 52,p. 5692 - 5701
[16]Chemistry - A European Journal,2008,vol. 14,p. 2894 - 2903
[17]Journal of the American Chemical Society,1998,vol. 120,p. 12860 - 12868
[18]CrystEngComm,2017,vol. 19,p. 802 - 810
[19]Chemische Berichte,1989,vol. 122,p. 1725 - 1728
[20]Tetrahedron Letters,2007,vol. 48,p. 3739 - 3743
[21]Bioorganic and Medicinal Chemistry,2019,vol. 27,p. 1130 - 1138
[22]Zeitschrift fur Anorganische und Allgemeine Chemie,2013,vol. 639,p. 1370 - 1383
[23]Dalton Transactions,2006,p. 2066 - 2071
[24]Synthesis,1999,p. 779 - 782
[25]Journal of Medicinal Chemistry,2003,vol. 46,p. 4904 - 4909
[26]Journal of the Chemical Society. Chemical communications,1992,p. 1300 - 1302
[27]Dalton Transactions,2008,p. 3207 - 3214
[28]Organic and Biomolecular Chemistry,2015,vol. 13,p. 3856 - 3862
[29]Journal of Materials Chemistry C,2017,vol. 5,p. 9053 - 9065
[30]CrystEngComm,2017,vol. 19,p. 5835 - 5843
[31]Chemical Communications,2018,vol. 54,p. 2421 - 2424
[32]Dalton Transactions,2018,vol. 47,p. 13408 - 13418
[33]Journal of the Iranian Chemical Society,2019,vol. 16,p. 373 - 384
[34]Chemistry - A European Journal,2020,vol. 26,p. 15664 - 15671
[35]RSC Advances,2021,vol. 11,p. 32942 - 32954

4
[ 288302-12-5 ]
[ 92642-09-6 ]
[ 158750-25-5 ]

Reference： [1]Tetrahedron Letters,1994,vol. 35,p. 6299 - 6302
[2]Chemistry - A European Journal,1997,vol. 3,p. 1815 - 1822

5
[ 35162-34-6 ]
[ 92642-09-6 ]
(C₆H₃(OCH₃)2(CH₃)NCH₂C₅H₃N)2 [ No CAS ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1992,p. 1300 - 1302

6
[ 92642-09-6 ]
[ 109-89-7 ]
[ 229021-45-8 ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1992,p. 1300 - 1302

7
[ 92642-09-6 ]
[ 121-44-8 ]
C₂₄H₄₀N₄⁽²⁺⁾ [ No CAS ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1992,p. 1300 - 1302

8
[ 92642-09-6 ]
[ 111-42-2 ]
2-[(5'-[Bis-(2-hydroxy-ethyl)-amino]-methyl}-[2,2']bipyridinyl-5-ylmethyl)-(2-hydroxy-ethyl)-amino]-ethanol [ No CAS ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1992,p. 1300 - 1302

9
[ 92642-09-6 ]
[ 100-61-8 ]
(C₆H₅(CH₃)NCH₂C₅H₃N)2 [ No CAS ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1992,p. 1300 - 1302

10
[ 92642-09-6 ]
[ 5961-59-1 ]
(C₆H₄OCH₃(CH₃)NCH₂C₅H₃N)2 [ No CAS ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1992,p. 1300 - 1302

11
[ 92642-09-6 ]
[ 32953-14-3 ]
(C₆H₃(OCH₂O)(CH₂CH₃)NCH₂C₅H₃N)2 [ No CAS ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1992,p. 1300 - 1302

12
[ 110-86-1 ]
[ 92642-09-6 ]
5,5'-bis(pyridyl-N-methylene)-2,2'-bipyridine bis(hexafluorophosphate) [ No CAS ]

Reference： [1]Journal of the Chemical Society. Perkin transactions II,1996,p. 1545 - 1552

13
[ 553-26-4 ]
[ 92642-09-6 ]
[ 144676-22-2 ]

Reference： [1]Journal of the American Chemical Society,2015,vol. 137,p. 13252 - 13255
[2]Journal of the Chemical Society. Perkin transactions II,1996,p. 1545 - 1552

14
[ 98-92-0 ]
[ 92642-09-6 ]
5,5'-bis(nicotinamide-N-methylene)-2,2'-bipyridine bis(hexafluorophosphate) [ No CAS ]

Reference： [1]Journal of the Chemical Society. Perkin transactions II,1996,p. 1545 - 1552

15
[ 92642-09-6 ]
[ 603-35-0 ]
5'-[[(bromomethyl)-2,2'-bipyridin-5-yl]methyl]phosphonium bromide [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1997,vol. 119,p. 12 - 21
[2]New Journal of Chemistry,2010,vol. 34,p. 2176 - 2182
[3]Chemistry - A European Journal,2008,vol. 14,p. 2894 - 2903

16
[ 92642-09-6 ]
[ 158750-25-5 ]
C₁₃₆H₁₄₄N₈O₈ [ No CAS ]

Reference： [1]Chemistry - A European Journal,1997,vol. 3,p. 1815 - 1822

17
[ 92642-09-6 ]
[ 122-52-1 ]
[ 190130-69-9 ]

Yield	Reaction Conditions	Operation in experiment
90 - 95%	at 80 - 85℃; for 10 - 12h;	Bisphosphonate were prepared by the reaction- of the corresponding bisbromomethyl derivatives (2 mmol) with 3 mL of triethyl phosphite at 80-85 0C for 10-12 h followed by the removal of the -unreacted triethyl phosphite by vacuum. Yield 90- 95%; 1H NMR (CDCI3, 300 MHz) δ 1.12 (m, 12H1 CH3), 3.21 (s, 4H, CH2P), 4.14 (m, 8H, OCH2), 7.34 (m, 2H, aromatic), 8.01 (m, 2H, aromatic), 8.30 (m, 2H, aromatic).

Reference： [1]Chemical Communications,2010,vol. 46,p. 6069 - 6071
[2]Patent: WO2009/84007,2009,A1 .Location in patent: Page/Page column 11
[3]Journal of the American Chemical Society,1997,vol. 119,p. 4622 - 4632
[4]Journal of the American Chemical Society,1998,vol. 120,p. 12860 - 12868

18
[ 1762-34-1 ]
[ 117585-58-7 ]
[ 92642-09-6 ]

Reference： [1]Inorganic Chemistry,2013,vol. 52,p. 5692 - 5701
[2]Chemistry - A European Journal,2008,vol. 14,p. 2894 - 2903
[3]Chemistry - A European Journal,2002,vol. 8,p. 2438 - 2445
[4]Synthesis,1998,p. 1339 - 1346

19
[ 112-53-8 ]
[ 92642-09-6 ]
[ 209408-86-6 ]

Reference： [1]Angewandte Chemie - International Edition,1998,vol. 37,p. 1255 - 1258

20
[ 92642-09-6 ]
5,5'-Bis-bromomethyl-[2,2']bipyridinyl 1,1'-dioxide [ No CAS ]

Reference： [1]Synthesis,1998,p. 1339 - 1346

21
[ 92642-09-6 ]
[ 105-53-3 ]
[ 92642-10-9 ]

Reference： [1]Journal of the American Chemical Society,1998,vol. 120,p. 3402 - 3410

22
6-(Lithiomethyl)-2,2'-bipyridin [ No CAS ]
[ 92642-09-6 ]
[ 243856-43-1 ]

Reference： [1]Journal of the Chemical Society, Dalton Transactions,1999,p. 2317 - 2321

23
[ 1539-42-0 ]
[ 92642-09-6 ]
5,5'-bis[(2,2'-dipicolylamino)methyl]-2,2'-bipyridine [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2003,vol. 125,p. 10184 - 10185
[2]Inorganic Chemistry,2013,vol. 52,p. 5692 - 5701

24
[ 92642-09-6 ]
[ 631898-94-7 ]

Reference： [1]Tetrahedron Letters,2006,vol. 47,p. 4907 - 4909
[2]Tetrahedron,2008,vol. 64,p. 8496 - 8503
[3]Inorganic Chemistry,2015,vol. 54,p. 4231 - 4242
[4]Journal of Medicinal Chemistry,2003,vol. 46,p. 4904 - 4909
[5]Dalton Transactions,2008,p. 3207 - 3214

25
[ 2725-53-3 ]
[ 92642-09-6 ]
[ 675123-28-1 ]

Reference： [1]Chemical Communications,2004,p. 152 - 153

26
[ 143998-20-3 ]
[ 92642-09-6 ]
[ 263403-96-9 ]
C₈₆H₉₆N₂O₂*C₃₈H₃₂I₂N₂O₆ [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2004,vol. 126,p. 8638 - 8639

27
[ 143998-20-3 ]
[ 92642-09-6 ]
[ 682742-35-4 ]

Reference： [1]Chemical Communications,2004,p. 474 - 476

28
[ 92642-09-6 ]
[ 17356-08-0 ]
2-(5'-carbamimidoylsulfanylmethyl-[2,2']bipyridinyl-5-ylmethyl)-isothiourea; compound with GENERIC INORGANIC NEUTRAL COMPONENT [ No CAS ]

Reference： [1]Macromolecules,2004,vol. 37,p. 7132 - 7139

29
[ 71-30-7 ]
[ 92642-09-6 ]
[ 330665-88-8 ]

Reference： [1]Journal of Coordination Chemistry,2010,vol. 63,p. 2440 - 2449
[2]New Journal of Chemistry,2000,vol. 24,p. 987 - 991

30
[ 92642-09-6 ]
[ 175854-39-4 ]
5,5'-bis(4,7,10-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclodecan-1-ylmethyl)-2,2'-bipyridine [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 9129 - 9139

31
C₅₄H₅₇N₂O₃⁽¹⁺⁾*F₆P^(1-) [ No CAS ]
[ 92642-09-6 ]
C₁₂₀H₁₂₄N₆O₆⁽⁴⁺⁾*4F₆P^(1-) [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2004,vol. 43,p. 2121 - 2124

32
[ 92642-09-6 ]
[ 60221-37-6 ]
5,5'-bis-(2-{2-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-ethoxy}-ethoxymethyl)-[2,2']bipyridinyl [ No CAS ]

Reference： [1]Organic Letters,2005,vol. 7,p. 5753 - 5756

33
[ 102-82-9 ]
[ 92642-09-6 ]
5,5'-di(1-(tributylammonio)methyl)-2,2'-dipyridyl dibromide [ No CAS ]

Reference： [1]Dalton Transactions,2006,p. 2066 - 2071

34
[ 92642-09-6 ]
[ 121-44-8 ]
5,5'-di[1-(triethylammonio)methyl]-2,2'-dipyridyl bromide [ No CAS ]

Reference： [1]Dalton Transactions,2006,p. 2066 - 2071

35
[ 92642-09-6 ]
[ 790663-86-4 ]
C₉₀H₁₀₂N₂₄O₆ [ No CAS ]

Reference： [1]Chemistry - A European Journal,2005,vol. 11,p. 6718 - 6726

36
[ 107-21-1 ]
[ 92642-09-6 ]
[ 942907-78-0 ]

Reference： [1]Tetrahedron Letters,2007,vol. 48,p. 3739 - 3743

37
[ 877082-56-9 ]
[ 92642-09-6 ]
[ 603-35-0 ]
C₂₄H₃₂O₆*C₄₈H₄₀N₂P₂⁽²⁺⁾*2H⁽¹⁺⁾*4PF₆^(1-) [ No CAS ]

Reference： [1]Chemical Communications,2007,p. 4122 - 4124

38
[ 92642-09-6 ]
[ 873865-95-3 ]

Reference： [1]Organic Letters,2005,vol. 7,p. 5753 - 5756

39
[ 92642-09-6 ]
[ 873865-91-9 ]

Reference： [1]Organic Letters,2005,vol. 7,p. 5753 - 5756

40
[ 92642-09-6 ]
[ 873865-93-1 ]

Reference： [1]Organic Letters,2005,vol. 7,p. 5753 - 5756

41
[ 92642-09-6 ]
[ 873865-97-5 ]

Reference： [1]Organic Letters,2005,vol. 7,p. 5753 - 5756

42
[ 92642-09-6 ]
5,5'-bis(1,4,7,10-tetraazacyclodecan-1-ylmethyl)-2,2'-bipyridine heptakis hydrobromide [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 9129 - 9139

43
[ 92642-09-6 ]
[ 894105-98-7 ]

Reference： [1]Angewandte Chemie - International Edition,2020,vol. 59,p. 17125 - 17129
Angewandte Chemie,2020,vol. 132,p. 17273 - 17277,5
[2]Macromolecules,2004,vol. 37,p. 7132 - 7139
[3]Chemical Communications,2019,vol. 55,p. 5025 - 5028

44
[ 92642-09-6 ]
[ 773072-70-1 ]

Reference： [1]Macromolecules,2004,vol. 37,p. 7132 - 7139

45
[ 92642-09-6 ]
[ 675123-32-7 ]

Reference： [1]Chemical Communications,2004,p. 152 - 153

46
[ 92642-09-6 ]
[ 675123-30-5 ]

Reference： [1]Chemical Communications,2004,p. 152 - 153

47
[ 92642-09-6 ]
[ 675123-36-1 ]

Reference： [1]Chemical Communications,2004,p. 152 - 153

48
[ 92642-09-6 ]
[ 675123-34-9 ]

Reference： [1]Chemical Communications,2004,p. 152 - 153

49
[ 92642-09-6 ]
[ 675123-38-3 ]

Reference： [1]Chemical Communications,2004,p. 152 - 153

50
[ 92642-09-6 ]
[ 303050-46-6 ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 4904 - 4909

51
[ 3510-66-5 ]
[ 92642-09-6 ]

Reference： [1]Synthesis,1999,p. 779 - 782
[2]Journal of the American Chemical Society,1998,vol. 120,p. 12860 - 12868
[3]Chemistry - A European Journal,2020,vol. 26,p. 15664 - 15671

52
[ 92642-09-6 ]
[ 219640-38-7 ]

Reference： [1]Journal of the American Chemical Society,1998,vol. 120,p. 12860 - 12868

53
[ 92642-09-6 ]
[ 153305-75-0 ]

Reference： [1]Journal of the American Chemical Society,1998,vol. 120,p. 3402 - 3410

54
[ 92642-09-6 ]
[ 92642-11-0 ]

Reference： [1]Journal of the American Chemical Society,1998,vol. 120,p. 3402 - 3410

55
[ 92642-09-6 ]
[ 203243-74-7 ]

Reference： [1]Journal of the American Chemical Society,1998,vol. 120,p. 3402 - 3410

56
[ 92642-09-6 ]
5,5'-Bis-[(E)-2-(2,5-bis-heptyloxy-4-iodo-phenyl)-vinyl]-[2,2']bipyridinyl [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1997,vol. 119,p. 4622 - 4632

57
[ 92642-09-6 ]
4-[(E)-2-(5'-Bromomethyl-[2,2']bipyridinyl-5-yl)-vinyl]-2,5-bis-decyloxy-benzaldehyde [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1997,vol. 119,p. 12 - 21

58
[ 92642-09-6 ]
2,5-bis(decyloxy)-1,4-bis[[5'-(bromomethyl)-2,2'-bipyridin-5-yl]vinyl]benzene [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1997,vol. 119,p. 12 - 21

59
[ 108-99-6 ]
[ 92642-09-6 ]

Reference： [1]Chemische Berichte,1989,vol. 122,p. 1725 - 1728

60
[ 108-89-4 ]
[ 92642-09-6 ]
2Br^(1-)*C₂₄H₂₄N₄⁽²⁺⁾ [ No CAS ]

Reference： [1]Organic Letters,2008,vol. 10,p. 321 - 324

61
[ 1006610-39-4 ]
[ 92642-09-6 ]
2Br^(1-)*C₆₂H₆₄N₈⁽²⁺⁾ [ No CAS ]

Reference： [1]Organic Letters,2008,vol. 10,p. 321 - 324

62
[ 6760-73-2 ]
[ 92642-09-6 ]
C₅₈H₆₀N₈⁽²⁺⁾*2F₆P^(1-) [ No CAS ]

Reference： [1]Organic Letters,2008,vol. 10,p. 321 - 324

63
[ 104768-86-7 ]
[ 92642-09-6 ]
tBu₂C₃₀H₂₈N₈O₂ [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2009,vol. 131,p. 17620 - 17629

64
[ 92642-09-6 ]
[ 122-52-1 ]
5,5'-bis(diethylphosphonomethyl)-2,2'-bipyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
95%	at 85℃; for 12h;	Bisphosphonate were prepared by the reaction of the corresponding bisbromomethyi derivatives (2 mmol) with 3 mL of triethyl phosphite at 85 C for 12 h followed by the removal of the unreacted triethyl phosphite by vacuum. Yield 90- 95%; NMR (C QC13,300 MHz) δ 1. 12 (m, 12H, CH (s , 4H , CH2P), 4.14 (m\| 8H, OCH2), 7.34 (m, 2H, aromatic), 8.01 (m, 2H , aromatic), 8.30 (m, 2H , aromatic).

Reference： [1]Patent: WO2011/33531,2011,A1 .Location in patent: Page/Page column 11; 14

65
[ 1298076-10-4 ]
[ 92642-09-6 ]
[ 1298076-05-7 ]

Reference： [1]Angewandte Chemie - International Edition,2011,vol. 50,p. 3715 - 3719

66
[ 15761-38-3 ]
[ 92642-09-6 ]
[ 1298076-08-0 ]

Reference： [1]Angewandte Chemie - International Edition,2011,vol. 50,p. 3715 - 3719

67
[ 2389-45-9 ]
[ 92642-09-6 ]
[ 1298076-09-1 ]

Reference： [1]Angewandte Chemie - International Edition,2011,vol. 50,p. 3715 - 3719

68
[ 27317-70-0 ]
[ 92642-09-6 ]
[ 1298076-07-9 ]

Reference： [1]Angewandte Chemie - International Edition,2011,vol. 50,p. 3715 - 3719

69
[ 111-77-3 ]
[ 92642-09-6 ]
[ 1347746-35-3 ]

Yield	Reaction Conditions	Operation in experiment
53%		Compound (12).[0087]Sodium hydride, (108 mg, 60% dispersion in mineral oil; 2.71 mmol) was suspended in dry THF (8.0 mL) in a flame-dried flask and it was cooled to 0 C. Di(ethylene glycol)methyl ether (360 mg, 3.0 mmol) was added slowly and stirred under an argon atmosphere for 30 min. The solution was slowly added to 5,5′-bis(bromomethyl)-2,2′-dipyridyl (1.0 g, 5.4 mmol) in THF (50 mL) and stirred for 2 h. See Zhang, L.; Clark, R. J.; Zhu, L. Chem. Eur. J. 2008, 14, 2894-2903. Then most of the THF was removed under vacuum. The residue was partitioned between CH2Cl2 and brine. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated. The crude product was purified using silica chromatography, using THF in CH2Cl2 (gradient 0-10%). The yield of (12) was 1.1 g (53%). 1H NMR (300 MHz, CDCl3, 25 C.) 8.68 (s, 1H), 8.63 (s, 1H), 8.38 (d, J=8.1 Hz, 2H), 7.82-7.86 (m, 2H), 4.65 (s, 2H), 4.53 (s, 2H), 3.65-3.54 (m, 8H), 3.39 (s, 3H). 13C NMR (125 MHz, CDCl3, 25 C.) 155.8, 154.9, 149.3, 148.6, 137.6, 136.6, 134.1, 133.6, 121.1, 121.0, 72.0, 70.7, 70.6, 69.9, 59.1, 29.7.

Reference： [1]Chemical Communications,2011,vol. 47,p. 11730 - 11732
[2]Patent: US2013/71936,2013,A1 .Location in patent: Paragraph 0086; 0087

70
[ 75-89-8 ]
[ 92642-09-6 ]
[ 1290640-16-2 ]

Yield	Reaction Conditions	Operation in experiment
75%		General procedure: The 30% CH3ONa/CH3OH (1.1 g) and RfCH2OH (6.0 mmol) were charged into a round-bottomed flask, then continuously stirred at ca 80 C under N2 atmosphere for 4 h before CH3OH was vacuum removed. The resulting fluorinated alkoxide (6.0 mmol) was then dissolved in 20 mL of dry THF, and bis(BrCH2)-2,2'-bpy (5.8 mmol; at 4,4'- or 5,5'-positions) added. The mixture was brought to reflux for overnight, and the completeness of the reaction was checked by the GC/MS. After the reaction, the solvent was removed by vacuum pump. The crude product was extracted using the separatory funnel from the CH2Cl2/H2O system several times. Then the crude product was further purified by either vacuum sublimation or column chromatography to obtain white solids. Analytical data of 2a: Yield 75%; 1H NMR (500 MHz, d-Me2SO): δ = 8.66 (2H, s, H-6), 8.39 (2H, d, 3JHH = 8.24 Hz, H-4), 7.92 (2H, d, 3JHH = 8.24 Hz, H-3), 4.77 (4H, s, bpyCH2), 4.17 (4H, q, 3JHF = 9.34 Hz, CF3CH2). 19F NMR (470.5 MHz, d-Me2SO): δ = -73.1 (6F, t, 3JHF = 10.8 Hz, CH2CF3). 13C NMR (126 MHz, d-Me2SO): δ = 71 (bpyCH2), 67 (bpyCH2OCH2), 121-128 (CF3), 120, 133, 137, 149, 155 (bpy); FT-IR [νmax(KBr)/cm-1]: 1598m, 1554m, 1469m, 1359m (νbpy), 1156vs, 1123vs (νCF2); m.p. = 120 C.GC/MS (m/z; EI mode): 380.1 [M]+, 297.1 [M-CH2CF3]+, 281.1 [M-OCH2CF3]+, 198.1 [M-O(CH2CF3)2]+, 182.1 [M-(OCH2CF3)2]+, 91.1 [M-(OCH2CF3)2-C6H5N]+.(m/z; CI mode): 420.9 [M+C3H5]+, 408.9 [M+C2H5]+, 381 [M+H]+, 360.9 [M-HF]+, 340.9 [M-(HF)2]+, 281 [M-OCH2CF3]+, 198.9 [M-O(CH2CF3)2+H]+, 100.9 [OCH3CF3+H]+, 80.9 [OCH3CF3-HF+H]+.

Reference： [1]Journal of Fluorine Chemistry,2012,vol. 137,p. 54 - 63

71
[ 422-05-9 ]
[ 92642-09-6 ]
[ 1373318-06-9 ]

Yield	Reaction Conditions	Operation in experiment
76%		General procedure: The 30% CH3ONa/CH3OH (1.1 g) and RfCH2OH (6.0 mmol) were charged into a round-bottomed flask, then continuously stirred at ca 80 C under N2 atmosphere for 4 h before CH3OH was vacuum removed. The resulting fluorinated alkoxide (6.0 mmol) was then dissolved in 20 mL of dry THF, and bis(BrCH2)-2,2'-bpy (5.8 mmol; at 4,4'- or 5,5'-positions) added. The mixture was brought to reflux for overnight, and the completeness of the reaction was checked by the GC/MS. After the reaction, the solvent was removed by vacuum pump. The crude product was extracted using the separatory funnel from the CH2Cl2/H2O system several times. Then the crude product was further purified by either vacuum sublimation or column chromatography to obtain white solids. Analytical data of 2b: Yield 76%; 1H NMR (500 MHz, d-Me2SO): δ = 8.64 (2H, s, H-6), 8.39 (2H, d, 3JHH = 8.51 Hz, H-4), 7.89 (2H, d, 3JHH = 8.24 Hz, H-3), 4.77 (4H, s, bpyCH2), 4.23 (4H, t, 3JHF = 14.01 Hz, CF3CH2). 19F NMR (470.5 MHz, d-Me2SO): δ = -122.9 (4F, t, 3JHF = 15.0 Hz, CH2CF2), -83.2 (6F, CH2CF2CF3). 13C NMR (126 MHz, d-Me2SO): δ = 71 (bpyCH2), 66 (bpyCH2OCH2), 111-122 (C2F5), 120, 133, 137, 149, 155 (bpy); FT-IR [νmax(KBr)/cm-1]: 1602m, 1554m, 1469m, 1366m (νbpy), 1189vs, 1152vs, 1115vs (νCF2); m.p. = 106 C.GC/MS (m/z; EI mode): 480.1 [M]+, 347.1 [M-CH2C2F5]+, 331.1 [M-OCH2C2F5]+, 198.1 [M-O(CH2C2F5)2]+, 182.1 [M-(OCH2C2F5)2]+, 91.1 [M-(OCH2C2F5)2-C6H5N]+.(m/z; CI mode): 520.9 [M+C3H5]+, 508.9 [M+C2H5]+, 480.9 [M+H]+, 330.9 [M-OCH2C2F5]+, 198.9 [M-O(CH2C2 F5)2+H]+, 150.9 [OCH3C2F5+H]+, 130.9 [OCH3C2F5-HF+H]+.

Reference： [1]Journal of Fluorine Chemistry,2012,vol. 137,p. 54 - 63

72
[ 375-01-9 ]
[ 92642-09-6 ]
[ 1373318-07-0 ]

Yield	Reaction Conditions	Operation in experiment
80%		General procedure: The 30% CH3ONa/CH3OH (1.1 g) and RfCH2OH (6.0 mmol) were charged into a round-bottomed flask, then continuously stirred at ca 80 C under N2 atmosphere for 4 h before CH3OH was vacuum removed. The resulting fluorinated alkoxide (6.0 mmol) was then dissolved in 20 mL of dry THF, and bis(BrCH2)-2,2'-bpy (5.8 mmol; at 4,4'- or 5,5'-positions) added. The mixture was brought to reflux for overnight, and the completeness of the reaction was checked by the GC/MS. After the reaction, the solvent was removed by vacuum pump. The crude product was extracted using the separatory funnel from the CH2Cl2/H2O system several times. Then the crude product was further purified by either vacuum sublimation or column chromatography to obtain white solids. Analytical data of 2c: Yield 80%; 1H NMR (500 MHz, d-Me2SO): δ = 8.64 (2H, s, H-6), 8.39 (2H, d, 3JHH = 7.97 Hz, H-4), 7.90 (2H, d, 3JHH = 8.24 Hz, H-3), 4.78 (4H, s, bpyCH2), 4.28 (4H, t, 3JHF = 14.28 Hz, CF3CH2). 19F NMR (470.5 MHz, d-Me2SO): δ = -127.5 (4F, s, CH2CF2), -120 (4F, m, CH2CF2CF2), -80.8 (6F, t, 3JFF = 8.63 Hz, CF2CF3). 13C NMR (126 MHz, d-Me2SO): δ = 71 (bpyCH2), 66 (bpyCH2OCH2), 105-118 (C3F7), 120, 133, 137, 149, 155 (bpy); FT-IR [νmax(KBr)/cm-1]: 1606m, 1554m, 1473m, 1359 (νbpy), 1174vs, 1119 vs (νCF2).GC/MS (m/z; EI): 580 [M]+, 397 [M-CH2C3F7]+, 381 [M-OCH2C3F7]+, 182 [M-(OCH2C3F7)2]+; m.p. = 95 C.GC/MS (m/z; EI mode): 580.1 [M]+, 397.1 [M-CH2C3F7]+, 381.1 [M-OCH2C3F7]+, 198.1 [M-O(CH2C3F7)2]+, 182.1 [M-(OCH2C3F7)2]+, 91.1 [M-(OCH2C3F7)2-C6H5N]+.(m/z; CI mode): 620.9 [M+C3H5]+, 608.9 [M+C2H5]+, 580.9 [M+H]+, 380.9 [M-OCH2C3F7]+, 198.9 [M-O(CH2C3F7)2+H]+, 200.9 [OCH3C3F7+H]+, 180.9 [OCH3C3F7-HF+H]+.

Reference： [1]Journal of Fluorine Chemistry,2012,vol. 137,p. 54 - 63

73
[ 335-99-9 ]
[ 92642-09-6 ]
[ 1373318-08-1 ]

Yield	Reaction Conditions	Operation in experiment
92%		General procedure: The 30% CH3ONa/CH3OH (1.1 g) and RfCH2OH (6.0 mmol) were charged into a round-bottomed flask, then continuously stirred at ca 80 C under N2 atmosphere for 4 h before CH3OH was vacuum removed. The resulting fluorinated alkoxide (6.0 mmol) was then dissolved in 20 mL of dry THF, and bis(BrCH2)-2,2'-bpy (5.8 mmol; at 4,4'- or 5,5'-positions) added. The mixture was brought to reflux for overnight, and the completeness of the reaction was checked by the GC/MS. After the reaction, the solvent was removed by vacuum pump. The crude product was extracted using the separatory funnel from the CH2Cl2/H2O system several times. Then the crude product was further purified by either vacuum sublimation or column chromatography to obtain white solids. Analytical data of 2d: Yield 92%; 1H NMR (500 MHz, d-Me2SO): δ = 8.65 (2H, s, H-6), 8.38 (2H, d, 3JHH = 8.2 Hz, H-4), 7.90 (2H, d, 3JHH = 8.2 Hz, H-3), 7.15 (2H, tt, 2JHF = 50.0 Hz, 2JHF = 5.2 Hz, CF2H), 4.78 (4H, s, bpyCH2), 4.27 (4H, t, 3JHH = 14.6 Hz, CF2CH2). 19F NMR (470.5 MHz, d-Me2SO): δ = -119.2, -122.6, -123.4, -123.5, -129.5 (20F; CH2(CF2)5), -138.8 (4F, d, 2JHF = 51.6 Hz, HCF2). 13C NMR (126 MHz, d-Me2SO): δ = 71 (bpyCH2), 66 (bpyCH2OCH2), 105-117 (C6F12H), 120, 133, 137, 149, 155 (bpy); FT-IR [νmax(KBr)/cm-1]: 1602m, 1560m, 1474m (νbpy), 1194vs, 1122vs (νCF2); m.p. = 96.6 C.GC/MS (m/z; EI mode): 844.1 [M]+, 529.1 [M-CH2C6F12H]+, 513.1 [M-OCH2C6F12H]+, 198.1 [M-O(CH2C6F12H)2]+, 182.1 [M-(OCH2C6F12H)2]+, 91.1 [M-(OCH2C6F12H)2-C6H5N]+.(m/z; CI mode): 884.9 [M+C3H5]+, 872.9 [M+C2H5]+, 844.9 [M+H]+, 512.9 [M-OCH2C6F12H]+, 182.9 [M-(OCH2C6F12H)2+H]+, 332.8 [OCH3C6F12H+H]+, 312.8 [OCH3C6F12H-HF+H]+.

Reference： [1]Journal of Fluorine Chemistry,2012,vol. 137,p. 54 - 63

74
[ 63361-65-9 ]
[ 92642-09-6 ]

Reference： [1]Journal of the American Chemical Society,2016,vol. 138,p. 1938 - 1946
[2]Organic and Biomolecular Chemistry,2013,vol. 11,p. 344 - 352

75
[ 92642-09-6 ]
C₃₆H₃₄N₁₂O₁₂Zn₂ [ No CAS ]

Reference： [1]Inorganic Chemistry,2013,vol. 52,p. 5692 - 5701

76
[ 92642-09-6 ]
C₃₆H₃₄Cl₂N₈Pd₂⁽²⁺⁾*2Cl^(1-) [ No CAS ]

Reference： [1]Inorganic Chemistry,2013,vol. 52,p. 5692 - 5701

77
[ 166525-55-9 ]
[ 92642-09-6 ]
C₃₈H₅₄N₄O₄Si₂ [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2013,vol. 52,p. 6464 - 6467
Angew. Chem.,2013,vol. 125,p. 6592 - 6595,4

78
[ 70-18-8 ]
[ 92642-09-6 ]
C₃₂H₄₂N₈O₁₂S₂ [ No CAS ]

Reference： [1]Zeitschrift fur Anorganische und Allgemeine Chemie,2013,vol. 639,p. 1370 - 1383

79
[ 92642-09-6 ]
[ 103-49-1 ]
[ 1494579-42-8 ]

Reference： [1]Inorganic Chemistry,2013,vol. 52,p. 14116 - 14123

80
ABA-DPAALKRARNTCAARRSRCRKLQ-CONH<SUB>2</SUB> [ No CAS ]
[ 92642-09-6 ]
C₁₂₇H₂₀₉N₄₉O₃₁S₂ [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2015,vol. 13,p. 3856 - 3862

81
[ 92642-09-6 ]
[ 122-52-1 ]
4,4′-bis(diethylmethylphosphonato)-2,2′-bipyridine [ No CAS ]

Reference： [1]Dalton Transactions,2015,vol. 44,p. 10423 - 10430

82
[ 852951-76-9 ]
[ 92642-09-6 ]
C₅₆H₆₂N₆O₂⁽²⁺⁾*2Br^(1-) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
96%	In tetrahydrofuran;Reflux;	General procedure: A mixture of <strong>[92642-09-6]5,5'-bis(bromomethyl)-2,2'-bipyridine</strong>2 (0.1g, 10 mmol), cinchona derivatives 3 (3a/ 3b, 20 mmol)was dissolved in 5 ml of THF and heated to reflux for overnight, the brown solid was filtered, washed withdiethylether and dried it to get pure di site chiral PTC. (96% yield of 4a and 98% yield of 4b).

Reference： [1]Tetrahedron Letters,2015,vol. 56,p. 5209 - 5212

83
[ 92642-09-6 ]
[ 118-10-5 ]
C₅₀H₅₄N₆O₂⁽²⁺⁾*2Br^(1-) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
96%	In tetrahydrofuran;Reflux;	General procedure: A mixture of <strong>[92642-09-6]5,5'-bis(bromomethyl)-2,2'-bipyridine</strong>2 (0.1g, 10 mmol), cinchona derivatives 3 (3a/ 3b, 20 mmol)was dissolved in 5 ml of THF and heated to reflux for overnight, the brown solid was filtered, washed withdiethylether and dried it to get pure di site chiral PTC. (96% yield of 4a and 98% yield of 4b).

Reference： [1]Tetrahedron Letters,2015,vol. 56,p. 5209 - 5212

84
[ 92642-09-6 ]
2,2'-bipyridine-5,5'-bis(methanesulfonic acid) dipotassium salt [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
86%	With potassium sulfite; In methanol; water; for 5h;Inert atmosphere; Reflux;	4,4’-bis(bromomethyl)-2,2’-bipyridine (230 mg, 0.673 mmol) and potassium sulfite(218 mg, 1.38 mmol) was added to water-methanol mixed solvent (3:1 in v/v). Themixture was refluxed under N2 atmosphere for 5 hours. After cooling to roomtemperature naturally, the reaction solution was concentrated by rotary evaporator andthen extracted by four potions of ethyl acetate (5 mL each). Obtained aqueous solutionwas concentrated and the added to hot isopropanol to afford white precipitates. Theprecipitate was collected by filtration, washed by isopropanol and diethylether, anddried under vacuum. Yield: 244 mg, 86%. 1 H NMR(D2O) : δ 8.65(d, 2H), 8.12(s, 2H),7.58(d, 2H), 4.34(s, 4H)

Reference： [1]Chemistry Letters,2016,vol. 45,p. 619 - 621
[2]Angewandte Chemie - International Edition,2015,vol. 54,p. 7981 - 7984
Angew. Chem.,2015,vol. 127,p. 8092 - 8095,4

85
[ 92642-09-6 ]
[ 190130-69-9 ]

Reference： [1]Journal of the American Chemical Society,2016,vol. 138,p. 1938 - 1946

86
[ 92642-09-6 ]
[ 135822-72-9 ]

Reference： [1]Green Chemistry,2019,vol. 21,p. 2295 - 2306
[2]Journal of Materials Chemistry C,2017,vol. 5,p. 9053 - 9065

87
[ 92642-09-6 ]
5,5'-bis(1,3-dihydroxy-4,4,5,5-tetramethylimidazolin-2-yl)-2,2'-bipyridine [ No CAS ]

Reference： [1]Journal of Materials Chemistry C,2017,vol. 5,p. 9053 - 9065

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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 92642-09-6 ] {[proInfo.proName]}

Quality Control of [ 92642-09-6 ]

Related Doc. of [ 92642-09-6 ]

Product Details of [ 92642-09-6 ]

Calculated chemistry of [ 92642-09-6 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 92642-09-6 ]

Application In Synthesis of [ 92642-09-6 ]

[ 92642-09-6 ] Synthesis Path-Downstream 1~87

Related Functional Groups of [ 92642-09-6 ]

Bromides

Related Parent Nucleus of [ 92642-09-6 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 92642-09-6 ]

Related Parent Nucleus of
[ 92642-09-6 ]