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[ CAS No. 933-20-0 ]

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2D
Chemical Structure| 933-20-0
Chemical Structure| 933-20-0
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Product Details of [ 933-20-0 ]

CAS No. :933-20-0MDL No. :MFCD00078331
Formula : C3H2Cl2N4 Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :164.98Pubchem ID :13615
Synonyms :

Computed Properties of [ 933-20-0 ]

TPSA : 64.7 H-Bond Acceptor Count : 4
XLogP3 : 1.5 H-Bond Donor Count : 1
SP3 : 0.00 Rotatable Bond Count : 0

Safety of [ 933-20-0 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 933-20-0 ]

  • Upstream synthesis route of [ 933-20-0 ]
  • Downstream synthetic route of [ 933-20-0 ]

[ 933-20-0 ] Synthesis Path-Upstream   1~6

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YieldReaction ConditionsOperation in experiment
99% With ammonium hydroxide In dichloromethane at 22 - 26℃; To a stirred solution of cyanuric chloride (2.16 g, 11.69 mmol)in anhydrous dichloromethane (10 mL) ammonium hydroxide(1 equiv) was added dropwise. The residue was purified with flashchromatography (ethyl acetate/dichloromethane 8:2) to affordcompound 18(I) a 99percent yield.
82% With ammonium hydroxide In water; acetone at 0 - 25℃; for 1.5 h; 2,4,6-Trichloro- 1 ,3,5-triazine (XVIII) (10.0 g, 55 mmol) was dissolved in acetone (80 mL) and poured into ice-water (80 mL) to form a very fine suspension.To this mixture, 1 N ammonium hydroxide solution (108 mL, 109.4 mmol) was added at 0°C. The reaction was stirred for 30 min at ambient temperature and for additional60 min at 25 °C. The precipitate was filtered off, washed with water (3 x 25 mL). After drying over calcium chloride under high vacuum, 6-amino-2,4-dichloro-[1,3>5]triazine (XXXVII) was isolated as white powder (7.4 g, 82percent yield). LCMS(ESl) m z = 165 (M+H)\\
70% With ammonium hydroxide In water; acetone Compound Numbers Make Reference to FIG. 4
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[25] Kogyo Kagaku Zasshi, [26] Kogyo Kagaku Zasshi, 1967, vol. 70, p. 2402 - 2403
[27] , Gmelin Handbook: C: MVol.D3, 7.2.8.5, page 284 - 285,
[28] Patent: WO2009/17288, 2009, A1, . Location in patent: Page/Page column 14-15
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[33] Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2014, vol. 78, # 1-4, p. 103 - 111
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  • 2
  • [ 1336-21-6 ]
  • [ 108-77-0 ]
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Reference: [1] Patent: US5536722, 1996, A,
  • 3
  • [ 108-77-0 ]
  • [ 933-20-0 ]
  • [ 3397-62-4 ]
Reference: [1] Journal of Organic Chemistry, 1958, vol. 23, p. 1802
[2] , Gmelin Handbook: C: MVol.D3, 7.2.8.5, page 284 - 285,
  • 4
  • [ 108-77-0 ]
  • [ 7664-41-7 ]
  • [ 67-64-1 ]
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Reference: [1] Journal of the American Chemical Society, 1948, vol. 70, p. 3726
[2] Journal of the American Chemical Society, 1951, vol. 73, p. 2981
  • 5
  • [ 123-91-1 ]
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  • [ 629-14-1 ]
  • [ 7664-41-7 ]
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Reference: [1] Journal of the American Chemical Society, 1948, vol. 70, p. 3726
[2] Journal of the American Chemical Society, 1951, vol. 73, p. 2981
  • 6
  • [ 67-56-1 ]
  • [ 933-20-0 ]
  • [ 16370-63-1 ]
Reference: [1] Journal of the American Chemical Society, 1951, vol. 73, p. 2986,2989
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