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[ CAS No. 93884-11-8 ] {[proInfo.proName]}

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Chemical Structure| 93884-11-8
Chemical Structure| 93884-11-8
Structure of 93884-11-8 * Storage: {[proInfo.prStorage]}
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Product Details of [ 93884-11-8 ]

CAS No. :93884-11-8 MDL No. :MFCD02861886
Formula : C10H13NO4S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 243.28 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 93884-11-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 93884-11-8 ]

[ 93884-11-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 582-33-2 ]
  • [ 124-63-0 ]
  • [ 93884-11-8 ]
YieldReaction ConditionsOperation in experiment
65% With silica gel at 20℃;
63% Stage #1: 3-aminobenzoic acid ethyl ester With sodium hydrogencarbonate In 1,4-dioxane; water Stage #2: methanesulfonyl chloride In 1,4-dioxane; water at 20℃; for 7h; 9 To a solution of 25.20 g (0.153 mol) of 3-aminoethylbenzoate in 600 ml of dioxane are added 800 mi of 5% NAHCO3 solution and 15 g of NAHCO3 and the mixture is stirred vigorously. An 80 ml solution of 48.7 ml (0.382 mol) of methanesulfonyl chloride in dioxane is added gradually at room temperature and the resultant mixture is stirred for about 7 hr. The reaction mixture is partitioned between ethyl acetate and 2N HCI. The organic layer is washed with water and saturated saline, dried over. MGS04 and concentrated to obtain a crude compound 2. Recrystallization from toluene/hexane give 29.24 g (0.0958 mi ; yield, 63%) of compound 2.
With pyridine In dichloromethane for 1h; Ambient temperature;
With pyridine In dichloromethane at 20℃; for 18h;
With pyridine In benzene

  • 2
  • [ 93884-11-8 ]
  • [ 28547-13-9 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide for 1h; Heating;
  • 3
  • [ 93884-11-8 ]
  • [ 376347-09-0 ]
YieldReaction ConditionsOperation in experiment
90% With lithium aluminium tetrahydride; In tetrahydrofuran; at 20℃; for 1.0h; Compound 3 To a 300 ml solution of 28.85 g (0.0945 mol) of compound 2 in THF is carefully added 5.32 g (0.140 mmol) of lithium aluminium hydride and the mixture is stirred for about 1 hr at room temperature. To the reaction mixture was added ethyl acetate and water under ice-cooling to decompose the excess of reducing agents. It was then partitioned between ethyl acetate and 2N HCI. the organic layer is washed with water and a saline, dried over MGS04, filtered and concentrated under reduced pressure to obtain a crude product. Recrystallization from methylene chloride/ether gives 22.34 g (0.0848 mol ; yield, 90%) of compound 3.
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