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Chemical Structure| 942399-85-1 Chemical Structure| 942399-85-1

Structure of 942399-85-1

Chemical Structure| 942399-85-1

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Product Details of [ 942399-85-1 ]

CAS No. :942399-85-1
Formula : C15H19F3O3
M.W : 304.30
SMILES Code : O=C(O)C1=CC=C(OCCCCCCC)C(C(F)(F)F)=C1

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Application In Synthesis of [ 942399-85-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 942399-85-1 ]

[ 942399-85-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 111-70-6 ]
  • [ 67515-55-3 ]
  • [ 942399-85-1 ]
YieldReaction ConditionsOperation in experiment
(28-1) Synthesis of 4-heptyloxy-3-trifluoromethylbenzoic acid (compound 28-1) To a suspension of potassium t-butoxide (20.7 g) in N,N-dimethylformamide (120 ml) was added n-heptanol (15.6 ml), and the mixture was stirred at room temperature for 30 min. A solution of <strong>[67515-55-3]4-fluoro-3-trifluoromethylbenzoic acid</strong> (16.7 g) in N,N-dimethylformamide (60 ml) was added dropwise to the reaction mixture at 0C, and the mixture was stirred at 70C for 1 hr. The reaction mixture was ice-cooled, water (320 ml) was added, and 6M-hydrochloric acid (40 ml) was added at room temperature. The mixture was stirred at room temperature for 30 min and precipitated crystals were collected by filtration. The crystals were dissolved in ethanol (60 ml) at 70C, water (96 ml) was added dropwise at the same temperature and the mixture was stirred for 30 min. The mixture was allowed to cool to room temperature, and stirred for 30 min under ice-cooling. The precipitated crystals were collected by filtration to give the object product (24.1 g) as pale-brown crystals. 1H-NMR(CDCl3)delta(ppm): 0.90(3H, t, J=6.6Hz), 1.28-1.49(8H, m), 1.80-1.90(2H, m), 4.13(2H, t, J=6.3Hz), 7.04(1H, d, J=8.7Hz), 8.24(1H, dd, J=2.1Hz, 9.0Hz), 8.33(1H, d, J=1.8Hz).
 

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