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1,3-dioxoisoindolin-2-yl cyclopentanecarboxylate[ No CAS ]
[ 91-64-5 ]
3-cyclopentyl-2H-chromen-2-one[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
78%
With 1,4-diaza-bicyclo[2.2.2]octane; tris(2,2′-bipyridine)ruthenium(II) dichloride hexahydrate In N,N-dimethyl acetamide at 20℃; for 2h; Schlenk technique; Sealed tube; Irradiation; regioselective reaction;
75%
With N,N,N,N,-tetramethylethylenediamine; triphenylphosphine; sodium iodide In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere; Irradiation; Sealed tube; regioselective reaction;
Typical procedure
General procedure: coumarin (1a, 0.2 mmol), cyclohexyl N-hydroxyphthalimide ester (2a, 0.24 mmol), NaI (1.5 equiv.), PPh3 (20 mmol %), TMEDA (2.0 equiv.), DMF (1.0 mL) were placed in 10 mL Schlenk tube under N2 atmosphere, then stirred under 20 W blue light for 3 h and monitored by GC or GC-MS or TLC. After completion of the reaction, the reaction mixture was diluted with EtOAc and washed with H2O. The organic layer was dried with anhydrous Na2SO4, filtered, and concentrated in vacuo. The residue was purified by column chromatography on silica gel and eluted with petroleum ether/ethyl acetate to afford the pure products.
With (1,2-dimethoxyethane)dichloronickel(II); Ir(p-CF<SUB>3</SUB>-ppy)<SUB>3</SUB>; N-ethyl-N,N-diisopropylamine; 4,4'-di-tert-butyl-2,2'-bipyridine In dimethyl sulfoxide at 23℃; for 16h; Irradiation; Inert atmosphere;
Chemistry
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Inhibitors/Agonists
Material Science
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110K+ Compounds
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