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Chemical Structure| 949090-27-1 Chemical Structure| 949090-27-1

Structure of 949090-27-1

Chemical Structure| 949090-27-1

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Product Details of [ 949090-27-1 ]

CAS No. :949090-27-1
Formula : C9H9BrO3
M.W : 245.07
SMILES Code : O=CC1=CC=C(C=C1Br)OCOC

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Application In Synthesis of [ 949090-27-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 949090-27-1 ]

[ 949090-27-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13057-17-5 ]
  • [ 22532-60-1 ]
  • [ 949090-27-1 ]
YieldReaction ConditionsOperation in experiment
92.8% With sodium hydride; In tetrahydrofuran; at 0 - 20℃; for 2h;Inert atmosphere; [00567] To a stirred solution of NaH (2.7 g, 68.7 mmol, 60%) in THF (50 mL) under N2 at 0 C was added <strong>[22532-60-1]2-bromo-4-hydroxybenzaldehyde</strong> (4.6 g, 22.9 mmol), bromo(methoxy)methane (4.3 g, 34.3 mmol), the mixture was stirred at rt for 2 h. The reaction mixture was added dropwise slowly to a cold saturated aqueous NaCl solution at 0 C. The mixture was extracted with EtOAc (20 mLx3), and the organic layers were washed with water, brine, dried and concentrated, purified by silica gel column chromatography (PE/EtOAc=4/l) to give 2-bromo-4-(methoxymethoxy)benzaldehyde (5.2 g, 92.8%) as a yellow solid. MS (EI+, m/z): No mass 1H NMR (500 MHz, DMSO) delta 10.10 (s, 1H), 7.84 (d, J= 8.7 Hz, 1H), 7.42 (d, J= 2.4 Hz, 1H), 7.20 (dd, J= 8.7, 2.3 Hz, 1H), 5.35 (s, 2H), 3.40 (s, 3H).
 

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