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Chemical Structure| 954-46-1 Chemical Structure| 954-46-1

Structure of 954-46-1

Chemical Structure| 954-46-1

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Product Details of [ 954-46-1 ]

CAS No. :954-46-1
Formula : C14H9NO2
M.W : 223.23
SMILES Code : O=[N+](C1=CC2=CC=CC=C2C3=CC=CC=C31)[O-]
MDL No. :MFCD00092278

Safety of [ 954-46-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H351
Precautionary Statements:P201-P202-P281-P308+P313-P405-P501

Application In Synthesis of [ 954-46-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 954-46-1 ]

[ 954-46-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 17024-12-3 ]
  • [ 954-46-1 ]
YieldReaction ConditionsOperation in experiment
73% With potassium nitrite; copper(II) bis(trifluoromethanesulfonate); In dimethyl sulfoxide; at 130℃; for 60h;Inert atmosphere; Sealed tube; General procedure: An oven dried pressure tube was charged with haloarenes (0.5 mmol), copper(II) triflate (45 mg, 0.125 mmol), KNO2 (128 mg, 1.5 mmol) and anhydrous DMSO (0.6 mL) under nitrogen atmosphere. The tube was sealed with a teflon screw cap having mininert valve and nitrogen is purged through it for 5 min. It is stirred at room temperature for 10 min and then the temperature was gradually increased to 130 oC and is maintained at the same for 48 h. The reaction mixture was then cooled to room temperature, washed with excess ice cold water and extracted with ethyl acetate (3 x 10 mL). The combined organic extracts were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give the crude product which was purified by column chromatography using silica gel (Table 2, entries 1-18) or basic alumina (Table 2, entries 19-23) and a mixture of ethyl acetate and hexane as the eluent to afford the desired products in good yields.
 

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