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Chemical Structure| 955038-21-8 Chemical Structure| 955038-21-8

Structure of 955038-21-8

Chemical Structure| 955038-21-8

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Product Details of [ 955038-21-8 ]

CAS No. :955038-21-8
Formula : C9H6F4O
M.W : 206.14
SMILES Code : O=CCC1=CC(C(F)(F)F)=CC(F)=C1
MDL No. :MFCD11110115

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Application In Synthesis of [ 955038-21-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 955038-21-8 ]

[ 955038-21-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 195447-79-1 ]
  • [ 955038-21-8 ]
YieldReaction ConditionsOperation in experiment
94% Example 13 Synthesis of Aldehyde Precursors to Compounds of Formula II 3-Fluoro-5-trifluoromethyl-phenylacetaldehyde To a solution of 5.0 g (21.2 mmol) of methyl-3-fluoro-5-trifluorophenylacetate in 21.2 mL of CH2Cl2 and 10.6 mL of hexane, cooled to -70 C. in an argon atmosphere, was added 17.0 mL (25.4 mmol) of a 1.5M solution of DIBAL-H in toluene over approximately two minutes. The mixture was allowed to warm to -50 C. over 1 h, and 21.2 mL of MeOH was added, followed by 14 mL of 6 N HCl and 21.2 mL of H2O. The mixture was extracted with EtOAc, and the EtOAc layer was washed sequentially with H2O and brine, dried (MgSO4), filtered, and concentrated. The residue was purified by silica gel chromatography (¼ EtOAc/hexane) to provide 4.10 g (94%) of product as a colorless oil: 1H NMR (CDCl3) delta 3.82 (s, 2H), 7.11-7.31 (m, 3H), 9.80 (s, 1H).
 

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