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Chemical Structure| 955428-54-3 Chemical Structure| 955428-54-3

Structure of 955428-54-3

Chemical Structure| 955428-54-3

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Product Details of [ 955428-54-3 ]

CAS No. :955428-54-3
Formula : C6H13NO
M.W : 115.17
SMILES Code : COC[C@H]1CNCC1
English Name :(R)-3-(Methoxylmethyl)pyrrolidine
MDL No. :MFCD19226723

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Application In Synthesis of [ 955428-54-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 955428-54-3 ]

[ 955428-54-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 955428-54-3 ]
  • [ 2422030-89-3 ]
  • [ 3056739-23-9 ]
YieldReaction ConditionsOperation in experiment
46 % With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 120℃; 181.1 Step 1) Preparation of (R)-4-(6-(3-(methoxymethyl)pyrrolidin-1-yl)pyridin-2-yl)thiazol-2-amine 4-(6-Fluoropyridin-2-yl)thiazol-2-amine (0.30 g, 1.54 mmol) was dissolved in DMSO (3 mL), and (R)-3-(methoxymethyl)pyrrolidine (0.35 g, 2.31 mmol) and DIPEA (1.34 mL, 7.69 mmol) were added, and the mixture was stirred at 120°C for 4 days. Afterwards, the reaction solution was cooled to room temperature, distilled water (20 mL) was added, and extracted with EA (30 mL*2). The extracted organic layer was dried with MgSO4and filtered under reduced pressure. The filtered solution was concentrated under reduced pressure and separated by column chromatography to obtain the target compound (0.21 g, yield: 46%).
 

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