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Chemical Structure| 960402-24-8 Chemical Structure| 960402-24-8

Structure of 960402-24-8

Chemical Structure| 960402-24-8

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Product Details of [ 960402-24-8 ]

CAS No. :960402-24-8
Formula : C15H18BrNO3
M.W : 340.21
SMILES Code : CC(C)(OC(N1CC(C(C2=CC=C(Br)C=C2)=O)C1)=O)C

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Application In Synthesis of [ 960402-24-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 960402-24-8 ]

[ 960402-24-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 820971-67-3 ]
  • [ 106-37-6 ]
  • [ 960402-24-8 ]
YieldReaction ConditionsOperation in experiment
62% To stirred solution of 1,4-dibromobenzene (5.07 g, 21.5 mmol, CAS 106-37-6) in dry THF (25 mL) at -78 C was added BuLi (1.6 M in hexane, 13.4 mL, 21.5 mmol). The reaction was allowed to warm up to -25 C for 30 min before being transferred via cannula to a solution of tert-butyl 3-(methoxy(methyl)carbamoyl)azetidine-l-carboxylate (3.5 g, 14.3 mmol) in THF (25 mL) at -78 C. After 90 min, the reaction was allowed to warm to -25 C before being quenched by addition of saturated aqueous NH4C1. The reaction was poured into water and extracted with EtOAc. The combined organic extracts were washed with brine, dried (Na2S04) and concentrated in vacuo. The residue was purified by flash chromatography (silica gel, gradient: 0% to 30% EtOAc in heptane) to afford the title compound (3.03 g, 62%) as a white solid. MS (ISP): 286.1 ([{ 81Br}M-C4H8 +H]+), 284.2 ([{79Br}M-C4H8 +H]+).
 

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