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Chemical Structure| 98552-51-3 Chemical Structure| 98552-51-3

Structure of 98552-51-3

Chemical Structure| 98552-51-3

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Product Details of [ 98552-51-3 ]

CAS No. :98552-51-3
Formula : C8H15NO2
M.W : 157.21
SMILES Code : O=C(OCC)C=CCN(C)C
MDL No. :N/A

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Application In Synthesis of [ 98552-51-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 98552-51-3 ]

[ 98552-51-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 867-13-0 ]
  • [ 3616-56-6 ]
  • [ 98552-51-3 ]
YieldReaction ConditionsOperation in experiment
89% In a round bottom flask, 2,2-diethoxy-N,N-dimethylethanamine (Formula III, 200 g) and deionized water (100 mL) were added at about 20°C to about 25°C. To the solution, concentrated hydrochloric acid (240 mL) was added at about 25°C to about 50°C. The temperature of the reaction mixture was raised to about 70°C. The reaction mixture was stirred at about 60°C to about 70°C for about 12 hours. The reaction mixture was cooled to about 0°C. To the reaction mixture, about 200 mL of aqueous potassium hydroxide (240 g in 250 mL water) was added at about 0°C to about 10°C to attain a pH of 9.0. To the reaction mixture, ethyl(diethoxyphosphoryl) acetate (200 g) and 2- methyltetrahydrofuran (600 mL) were added at about 0°C to about 5°C. Further, 50 mL of aqueous potassium hydroxide was added to the reaction mixture at about -5°C to about 0°C to attain a pH of about 13.5. The reaction mixture was stirred at about -5°C to about 0°C for about 1 hour. The reaction mixture was filtered, and then the filtrate was recovered under vacuum at about 45°C to about 50°C to obtain ethyl-4- (dimethylamino)crotonate as an oily mass. Yield: 89percent
 

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