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[ CAS No. 99614-01-4 ]

{[proInfo.proName]} (Synonyms:GR 3832 HCl; SN-37 HCl; NSC665799 HCl) ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 99614-01-4
Chemical Structure| 99614-01-4
Structure of 99614-01-4 *Storage: {[proInfo.prStorage]}

Quality Control of [ 99614-01-4 ]

Related Doc. of [ 99614-01-4 ]

SDS
Alternatived Products of [ 99614-01-4 ]
Alternatived Products of [ 99614-01-4 ]

Product Details of [ 99614-01-4 ]

CAS No. :99614-01-4MDL No. :MFCD00764297
Formula : C18H20ClN3O Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :329.82Pubchem ID :-
Synonyms :

1. Ondansetron hydrochloride

Computed Properties of [ 99614-01-4 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 99614-01-4 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 99614-01-4 ]

  • Upstream synthesis route of [ 99614-01-4 ]
  • Downstream synthetic route of [ 99614-01-4 ]

[ 99614-01-4 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 99614-01-4 ]
  • [ 99614-02-5 ]
YieldReaction ConditionsOperation in experiment
92% With sodium hydroxide In ethanol; waterHeating / reflux 680 g of ondansetron hydrochloride dihydrate was dissolved in 4000 ml of ethanol at reflux. A solution of 82 g of NAOH in 1000ML of water was added. A solid was formed. 3000 ml of water was added and the mixture was cooled to ambient temperature. The solid was filtered off and washed with 2*500 ml of water. The solid was dried at 50°C under vacuum for 2 days. The product exhibited the DSC curve shown in fig. 1 and the XRPD pattern of fig. 2. Yield : 527 g (96percent)80 g of ondansetron hydrochloride dihydrate was suspended in 500 ml of ethanol and heated to reflux until a clear solution was obtained. To this solution, 250 ml of a 1 M NAOH solution was added. During addition a solid started to form. 250 ml of water was added and the mixture was slowly cooled to room temperature. The mixture was cooled to 10- 15°C and the solid was filtered off. The solid was washed with 2X200 ml of water. After drying in a vacuumoven at 40°C for 3 days. 59.3 g of a white solid was obtained. The product exhibited the DSC curve shown in fig. 3 and the XRPD pattern of fig. 4. Yield : 59.3 g (92percent)
Reference: [1] Patent: WO2004/63189, 2004, A1, . Location in patent: Page 20-21
[2] Patent: WO2005/80381, 2005, A1, . Location in patent: Page/Page column 17-18
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