CAS No. :	536-33-4
Formula :	C₈H₁₀N₂S
M.W :	166.24
SMILES Code :	NC(C1=CC(CC)=NC=C1)=S
Synonyms :	2-Ethylthioisonicotinamide; NSC 255115; Bayer 5312
MDL No. :	MFCD00057361
InChI Key :	AEOCXXJPGCBFJA-UHFFFAOYSA-N
Pubchem ID :	2761171

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335-H351-H361
Precautionary Statements:	P261-P305+P351+P338

Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs)	100 μM	72 hours	Ethionamide preconditioning enhanced the proliferation of WJ-MSCs by activating PI3K/Akt and MEK/ERK1/2 signaling pathways.	Int J Mol Sci. 2020 Sep 23;21(19):7013
Human lung microsomes	200 μM	5 minutes	To study the metabolism of ethionamide in human lung microsomes, it was found that the FMO2 genetic polymorphism affects the metabolism of ethionamide.	Toxicol Appl Pharmacol. 2008 Dec 15;233(3):420-7
Mouse liver and lung microsomes	200 μM	5 minutes	To study the metabolism of ethionamide in mouse liver and lung microsomes, it was found that ethionamide was oxidized to ETASO, and this reaction was primarily catalyzed by FMOs rather than CYP.	Toxicol Appl Pharmacol. 2008 Dec 15;233(3):420-7
Sf9 insect cells	200 μM	5 minutes	To study the metabolism of ethionamide in Sf9 insect cells, it was found that all mouse and human FMOs (except hFMO5) oxidized ethionamide to ethionamide-S-oxide (ETASO).	Toxicol Appl Pharmacol. 2008 Dec 15;233(3):420-7
Mycobacterium tuberculosis	50 μg/ml	7 days	To evaluate the effect of CinA deletion on the bactericidal effect of Ethionamide. Results showed that CinA deletion enhanced the killing of non-replicating Mtb by Ethionamide.	Nat Commun. 2022 Apr 22;13(1):2203

Swiss mice	Tuberculosis model	Gavage	50 mg/kg	5 days per week for 6 months	To evaluate the bactericidal and sterilizing activity of a second-line antituberculous regimen containing ethionamide. Results showed higher relapse rates for fluoroquinolone-resistant strains compared to the wild-type, correlating with resistance levels.	Antimicrob Agents Chemother. 2013 Sep;57(9):4496-500
BALB/c mice	Latent tuberculosis infection model	Gavage	50 mg/kg	Daily administration for 6 months	Evaluate the efficacy of ethionamide combined with moxifloxacin in treating latent tuberculosis infection. Results showed that the combination of ethionamide and moxifloxacin was more effective than the recommended regimen of pyrazinamide plus ethambutol.	Am J Respir Crit Care Med. 2005 Dec 1;172(11):1452-6
BALB/c mice	Tuberculosis model	Oral	50 mg/kg	5 days per week for 2-7 months	To evaluate the bactericidal and sterilizing activity of Ethionamide in second-line regimens containing fluoroquinolones. Results showed that Ethionamide, when combined with moxifloxacin or high-dose levofloxacin and extended use of pyrazinamide, significantly enhanced sterilizing activity.	Am J Respir Crit Care Med. 2013 Jul 1;188(1):97-102
Mice	Wild-type C57BL/6J and Fmo1/2/4 knockout mice	Oral gavage	125 mg/kg	Single dose, observation time from 0.25 to 3.5 hours	To assess the impact of the FMO2 genetic polymorphism on the pharmacokinetics of ETA. Results showed that in WT mice, plasma concentrations of the metabolite ETASO were higher than the parent ETA, whereas in KO mice, ETA concentrations were higher than ETASO.	Pharmaceuticals (Basel). 2012;5(11):1147-59
BALB/c female mice	Pulmonary tuberculosis mouse model		10 mg/kg/day	Once daily, 5 days a week, for 4 weeks	To evaluate the synergistic effect of PPs with ETH in a pulmonary tuberculosis mouse model, results showed that the bacterial load in the lungs was significantly lower in the combination group than in the ETH-alone group.	Antibiotics (Basel). 2022 Oct 4;11(10):1349
Mice	Mycobacterium tuberculosis H37Rv-infected mice	Oral and inhalation	Oral: 4.7 mg ETO + 2.35 mg DCS; Inhalation: 70 μg ETO + 35 μg DCS	20 daily doses for 4 weeks	To evaluate the pharmacokinetics and anti-tuberculosis efficacy of DCS and ETO combination. Inhalation significantly reduced the bacterial load in lungs and spleen, showing bactericidal activity.	Antimicrob Agents Chemother. 2019 May 24;63(6):e00099-19
Mice	Tuberculosis model	Oral	50 mg/kg	5 times per week for 2 months	Evaluate the therapeutic effect of Ethionamide in combination with other drugs on multidrug-resistant tuberculosis. Results showed that R207910-containing regimens were significantly more active than non-R207910-containing regimens.	Antimicrob Agents Chemother. 2006 Nov;50(11):3543-7

NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... More >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD Less <<
NCT02365623	Tuberculosis, Multidrug-Resist... More >>ant Less <<	Phase 2	Active, not recruiting	September 12, 2020	Japan ... More >> Kiyose, Japan Sakai, Japan Less <<
NCT00000796	HIV Infections ... More >> Tuberculosis Less <<	Not Applicable	Completed	-	United States, Illinois ... More >> Cook County Hosp Chicago, Illinois, United States, 60612 United States, Michigan Henry Ford Hosp Detroit, Michigan, United States, 48202 United States, New York Bronx Lebanon Hosp Ctr Bronx, New York, United States, 10456 Bronx Municipal Hosp Ctr/Jacobi Med Ctr Bronx, New York, United States, 10461 Comprehensive Health Care Ctr / Bronx Municipal Hosp Bronx, New York, United States, 10461 Montefiore Drug Treatment Ctr / Bronx Municipal Hosp Bronx, New York, United States, 10461 Montefiore Family Health Ctr / Bronx Municipal Hosp Bronx, New York, United States, 10461 Samaritan Village Inc / Bronx Municipal Hosp Bronx, New York, United States, 10461 Jack Weiler Hosp / Bronx Municipal Hosp Bronx, New York, United States, 10465 Montefiore Med Ctr / Bronx Municipal Hosp Bronx, New York, United States, 10467 North Central Bronx Hosp / Bronx Municipal Hosp Bronx, New York, United States, 10467 Interfaith Med Ctr Brooklyn, New York, United States, 112032098 SUNY / Health Sciences Ctr at Brooklyn Brooklyn, New York, United States, 112032098 Beth Israel Med Ctr New York, New York, United States, 10003 Clinical Directors Network of Region II New York, New York, United States, 10011 Bellevue Hosp / New York Univ Med Ctr New York, New York, United States, 10016 Saint Clare's Hosp and Health Ctr New York, New York, United States, 10019 Cornell Univ Med Ctr New York, New York, United States, 10021 Mount Sinai Med Ctr New York, New York, United States, 10029 Columbia Presbyterian Med Ctr New York, New York, United States, 100323784 Harlem AIDS Treatment Group / Harlem Hosp Ctr New York, New York, United States, 10037 Less <<
NCT03237182	Tuberculosis, Multidrug-Resist... More >>ant Less <<	Phase 4	Recruiting	December 2021	South Africa ... More >> King Dinuzulu Hospital Recruiting Durban, Kwa-Zulu Natal, South Africa Contact: Nesri Padayatchi, MBcHB 0312604550 nesri.padayatchi@caprisa.org Contact: Resha Boodhram, BTech 0828383651 resha.boodhram@caprisa.org Less <<
NCT02975570	Tuberculosis Multi Drug Resist... More >>ant Active Less <<	Phase 3	Withdrawn(The study could not ... More >>be conducted since funding was not obtained.) Less <<	August 2022	-
NCT02454205	Tuberculosis ... More >>Multidrug Resistant Tuberculosis Extensively-drug Resistant Tuberculosis Less <<	Phase 2 Phase 3	Recruiting	January 2019	South Africa ... More >> Brooklyn Chest Hospital Recruiting Cape Town, Western Cape, South Africa, 7441 Contact: Ali Esmail, MD 0214047654 ext 6119 a.esmail@uct.ac.za Contact: Lynelle Mottay, MD 0214046119 ext 6119 lynelle.mottay@uct.ac.za Less <<
NCT03625739	-		Recruiting	December 31, 2026	China ... More >> Beijing Children's Hospital of Capital Medical University Recruiting Beijing, China Contact: Adong Shen, Master 13370115087 shenad16@hotmail.com Less <<
NCT00042289	HIV Infections	Phase 4	Recruiting	September 30, 2019	-
NCT02727582	-		Recruiting	February 28, 2019	South Africa ... More >> Brooklyn Chest Hospital Recruiting Cape Town, Western Cape, South Africa, 7725 Contact: Richard G Court +27214066779 richard.court@uct.ac.za Contact: Nihal DeVries Nihal.DeVries@westerncape.gov.za Sub-Investigator: Richard G Court Principal Investigator: Helen M McIlleron DP Marias Hospital Recruiting Cape Town, Western Cape, South Africa, 7725 Contact: Richard Dr Court +27214066779 richard.court@uct.ac.za Contact: Joseph Dr Harding Joseph.Harding@westerncape.gov.za Principal Investigator: Helen McIlleron Sub-Investigator: Richard Court Less <<

{[proInfo.proName]}

CAS No.: 536-33-4

{[proInfo.proName]}

CAS No.: 536-33-4

Alternative Products

Product Details of Ethionamide

Safety of Ethionamide

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed