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Chemical Structure| 2671128-05-3 Chemical Structure| 2671128-05-3

Structure of FHD-286
CAS No.: 2671128-05-3

Chemical Structure| 2671128-05-3

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FHD-286 is a selective and orally active inhibitor of the SMARCA4/SMARCA2 ATPases (BRG1 and BRM). It shows potential in the study of acute myeloid leukemia and other BAF-associated diseases.

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Product Details of FHD-286

CAS No. :2671128-05-3
Formula : C24H30N6O6S2
M.W : 562.66
SMILES Code : O=C(N[C@H](C(NC1=NC(C2=CC=CC(N3C[C@H](C)O[C@H](C)C3)=N2)=CS1)=O)COC)C4=CN(S(C)(=O)=O)C=C4
MDL No. :MFCD34662947

Safety of FHD-286

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of FHD-286

epigenetics

Isoform Comparison

Biological Activity

Description
FHD-286 is a selective, orally administered inhibitor of the SMARCA4/SMARCA2 ATPase activities of BRG1 and BRM. FHD-286 is being investigated for potential therapeutic applications in BAF (BRG1/BRM-associated factor)-related disorders such as acute myeloid leukemia[1].

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT04879017 Metastatic Uveal Melanoma PHASE1 TERMINATED 2023-11-30 The Angeles Clinic and Researc... More >>h Institute, Los Angeles, California, 90025, United States|University of Miami Health System, Sylvester Comprehensive Cancer Center, Miami, Florida, 33136, United States|Massachusetts General Hospital, Boston, Massachusetts, 02114, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02215, United States|Columbia University, Herbert Irving Comprehensive Cancer Center, New York, New York, 10032, United States|Memorial Sloan Kettering Cancer Center, New York, New York, 10065, United States|Sidney Kimmel Cancer Center - Jefferson Health, Philadelphia, Pennsylvania, 19107, United States|Sarah Cannon Research Institute, Nashville, Tennessee, 37205, United States|MD Anderson Cancer Center, Houston, Texas, 77030, United States|Institute Curie Hospital, Paris, France|Leiden University Medical Center, Leiden, Netherlands Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.78mL

0.36mL

0.18mL

8.89mL

1.78mL

0.89mL

17.77mL

3.55mL

1.78mL

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