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Chemical Structure| 152120-54-2 Chemical Structure| 152120-54-2
Chemical Structure| 152120-54-2

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Hirozumi, Ryosuke ; Kudo, Yuta ; Cho, Yuko ; Konoki, Keiichi ; Yotsu-Yamashita, Mari ;

Abstract: Mauritamide B (1a) is a taurine-connected cyclic guanidino-bromopyrrole alkaloid originally isolated from the marine sponge Agelas linnaei. To date, the total synthesis of taurine-connected guanidino-bromopyrrole alkaloids, including this compound, has not yet been reported. Herein, a total synthesis of (±)-mauritamide B (1b) was achieved by oxidation of 2-aminoimidazole of dihydro-sventrin (10) using activated carbon and air in the presence of taurine. The synthetic precursor of 10, 4-(3-aminopropyl)-2-aminoimidazole (22), was synthesized via our original route. The NMR data of the obtained product agreed with that reported for mauritamide B (1a). However, a detailed analysis of the NMR data of synthetic (±)-mauritamide B (1b) including 11H−15N HSQC spectrum revealed the need for a structural revision of the reported structure for mauritamide B (1b).

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Product Details of N,N'-Di-Boc-1H-pyrazole-1-carboximidamide

CAS No. :152120-54-2
Formula : C14H22N4O4
M.W : 310.35
SMILES Code : C(=O)(OC(C)(C)C)NC([N]1C=CC=N1)=NC(OC(C)(C)C)=O
MDL No. :MFCD01075122

Safety of N,N'-Di-Boc-1H-pyrazole-1-carboximidamide

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of N,N'-Di-Boc-1H-pyrazole-1-carboximidamide

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 152120-54-2 ]
  • Downstream synthetic route of [ 152120-54-2 ]

[ 152120-54-2 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 152120-54-2 ]
  • [ 143824-77-5 ]
References: [1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 4, p. 855 - 857.
 

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