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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 6338-55-2 Chemical Structure| 6338-55-2
Chemical Structure| 6338-55-2

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NH2-PEG3 (PROTAC Linker 35) is a polyethylene glycol (PEG)-based PROTAC linker used in the synthesis of PROTAC (β-NF-JQ1).

4.5 *For Research Use Only !

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Product Details of NH2-PEG3

CAS No. :6338-55-2
Formula : C6H15NO3
M.W : 149.19
SMILES Code : NCCOCCOCCO
MDL No. :MFCD07367495
InChI Key :ASDQMECUMYIVBG-UHFFFAOYSA-N
Pubchem ID :95875

Safety of NH2-PEG3

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H318
Precautionary Statements:P280-P305+P351+P338
Class:8
UN#:2735
Packing Group:

Application In Synthesis of NH2-PEG3

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6338-55-2 ]

[ 6338-55-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 6338-55-2 ]
  • [ 1709-71-3 ]
  • 2-methyl-acrylic acid 2-hydroxy-3-(3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethylamino}-propionyloxy)-propyl ester [ No CAS ]
  • 2
  • [ 6338-55-2 ]
  • [ 1709-71-3 ]
  • 2-methyl-acrylic acid 2-hydroxy-3-[3-({2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethyl}-{2-[2-hydroxy-3-(2-methyl-acryloyloxy)-propoxycarbonyl]-ethyl}-amino)-propionyloxy]-propyl ester [ No CAS ]
  • 3
  • [ 6338-55-2 ]
  • [ 120550-35-8 ]
  • [ 289714-02-9 ]
YieldReaction ConditionsOperation in experiment
94% With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20℃; for 10h;Inert atmosphere; A mixture of compound 3 (1.26 g, 8.45 mmol) and DIEA (2.70 g, 20.89 mmol) in dry DMF (5 mL) was added to a solution ofcompound 4 (2.90 g, 7.06 mmol) in dry DMF (20 mL) at 0 C. The mixture was stirred at 0 C for 30 min then stirred for 10 h at room temperature under nitrogen atmosphere. DMF was then removed under reduced pressure at 80 C, and the crude product was dissolved with DCM then the organic phase washed with brine solution and dried over MgSO4. Purification with column chromatography on silica gel with DCM/MeOH (15:1, v/v) as eluent affords the product as white powder with a yield of 94% (2.50 g). 1H NMR (DMSO-d6): delta 1.27-1.51 (m, 6H, CH2), 2.05 (t, 2H, CH2), 2.55 (d, 1H, CH2), 2.79-2.83 (m,1H, CH2), 3.08 (t, 1H, CH), 3.09 (t, 2H, CH2), 3.15-3.51 (m,10H, CH2), 4.10 (d, 1H, CH), 4.28 (d,1H, CH), 4.60 (t, 1H, OH), 6.35 (s, 1H, NH), 6.41 (s, 1H, NH), 7.84 (s,1H, NH).
 

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