Structure of Nerandomilast
CAS No.: 1423719-30-5
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Nerandomilast is a PDE4B inhibitor used in studies of inflammation, allergic diseases, and pulmonary fibrosis.
Synonyms: BI 1015550
4.5
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 1423719-30-5 |
Formula : | C20H25ClN6O2S |
M.W : | 448.97 |
SMILES Code : | OCC1(NC2=C3C(CC[S@]3=O)=NC(N4CCC(C5=NC=C(Cl)C=N5)CC4)=N2)CCC1 |
Synonyms : |
BI 1015550
|
MDL No. : | N/A |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319 |
Precautionary Statements: | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
In Vitro:
Concentration | Treated Time | Description | References |
LN-95, LTL331R, LAPC-4 | 0.01–1 µM | 1 day (LAPC-4) or 3 days (LN-95, LTL331R) | To evaluate the effect of bomedemstat on H3K4me2 levels. Bomedemstat treatment resulted in a dose-dependent increase in global levels of H3K4me2. | Prostate. 2024 Jul;84(10):909-921. |
AML cell line MV(4;11) | 2 to 2000 nM | 24 hours | To assess in vitro efficacy in hematological tumors (AML). | ACS Pharmacol Transl Sci. 2021 Nov 12;4(6):1818-1834. |
Small airway epithelial cells (SAECs) | 0.01-10 µM | 30 min | In a concentration-dependent manner, nerandomilast inhibited the accumulation of these (bio)markers with half-maximal inhibitory concentration values of 5.4, 0.7, 1.3 and 1.3 μM, respectively. | Br J Pharmacol. 2024 Dec;181(23):4766-4781. |
PBMCs | 1-100,000 nM | 4 hours | In human PBMCs, BI 1015550 inhibited LPS-induced TNF- α release with an IC50 of 35 nmol/L, and inhibited phytohemagglutinin P-induced IL-2 release with an IC50 of 9 nmol/L. | Front Pharmacol. 2023 May 30;14:1219760. |
LNCaP, LAPC-4, CWR22Rv1, PC3, DU145 | 10 µM | 5–7 days | To assess the antiproliferative activity of bomedemstat compared to pargyline and clorgyline. Bomedemstat showed equivalent or greater efficacy than pargyline and clorgyline at equimolar doses. | Prostate. 2024 Jul;84(10):909-921. |
RP-116 cells | 1 µM | 96 hours | Bomedemstat did not substantially reduce cell growth at a dose of up to 10 micromolar. | Clin Cancer Res. 2022 Oct 14;28(20):4551-4564. |
RP-48 cells | 1 µM | 96 hours | Bomedemstat did not substantially reduce cell growth at a dose of up to 10 micromolar. | Clin Cancer Res. 2022 Oct 14;28(20):4551-4564. |
AML cell line TF-1a | 0.002 to 2000 nM | 96 hours | To assess in vitro efficacy in hematological tumors (AML). | ACS Pharmacol Transl Sci. 2021 Nov 12;4(6):1818-1834. |
THP-1 cells | 0.02 to 2000 nM | 96 hours | To assess in vitro efficacy in hematological tumors (AML). | ACS Pharmacol Transl Sci. 2021 Nov 12;4(6):1818-1834. |
SET-2 cells | 50 nM, 100 nM, and 1 µM | 96 hours | IMG-7289 induced apoptosis in SET-2 cells, as indicated by Annexin V/PI staining. | Hemasphere. 2018 Jun 8;2(3):e54. |
Baf/3 WT cells | 50 nM, 100 nM, and 1 µM | 96 hours | IMG-7289 caused a statistically highly significant and dose-dependent increase in apoptosis of Jak2V617F Baf/3 cells over Baf/3 WT cells. | Hemasphere. 2018 Jun 8;2(3):e54. |
Jak2V617F Baf/3 cells | 50 nM, 100 nM, and 1 µM | 96 hours | IMG-7289 caused a statistically highly significant and dose-dependent increase in apoptosis of Jak2V617F Baf/3 cells over Baf/3 WT cells. | Hemasphere. 2018 Jun 8;2(3):e54. |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Rats | Suncus Murinus and Wistar Rats | Oral gavage | 0.1, 0.3, and 1.0 mg/kg | 30 min before LPS exposure | Lipopolysaccharide-Induced Neutrophil Influx Into the Bronchoalveolar Lavage Fluid of Male Suncus Murinus and Wistar Rats | Front Pharmacol. 2023 May 30;14:1219760. |
Wistar rats | Bleomycin-induced lung fibrosis model | Oral gavage | 2.5 mg/kg | Twice daily from Day 10 to Day 20 | To address the therapeutic potential of nerandomilast in a model of bleomycin-induced fibrosis in rats, we first measured lung function parameters. | Br J Pharmacol. 2024 Dec;181(23):4766-4781. |
Mice | NMRI mice | Oral gavage | 3.0, 1.0, 0.1, and 0.01 mg/kg | Lipopolysaccharide-Induced Tumor Necrosis Factor-α Release in Whole Blood Ex Vivo in Mice | Front Pharmacol. 2023 May 30;14:1219760. |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT05661344 | Hepatic Insufficiency | PHASE1 | COMPLETED | 2023-09-13 | CRS Clinical Research Services... More >> Kiel GmbH, Kiel, 24105, Germany Less << |
NCT06408870 | Healthy | PHASE1 | COMPLETED | 2024-08-28 | CRS Clinical Research Services... More >> Mannheim GmbH, Mannheim, 68167, Germany Less << |
NCT06415045 | Healthy | PHASE1 | COMPLETED | 2024-07-24 | CRS Clinical Research Services... More >> Berlin GmbH, Berlin, 13627, Germany Less << |
NCT06139302 | Healthy | PHASE1 | COMPLETED | 2024-02-13 | SOUSEIKAI Sumida Hospital, Tok... More >>yo, Sumida-ku, 130-0004, Japan Less << |
NCT06238622 | Idiopathic Pulmonary Fibrosis|... More >>Progressive Pulmonary Fibrosis Less << | PHASE3 | RECRUITING | 2027-05-05 | University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35233, United States|University of Arizona, Tucson, Arizona, 85724, United States|University of Southern California, Los Angeles, California, 90033, United States|Cedars-Sinai Medical Center, Los Angeles, California, 90048, United States|University of California Los Angeles, Los Angeles, California, 90095, United States|University of California Davis, Sacramento, California, 95817, United States|National Jewish Health, Denver, Colorado, 80206, United States|Yale University School of Medicine, New Haven, Connecticut, 06510, United States|Christiana Hospital, Newark, Delaware, 19713, United States|Georgetown University, Washington, District of Columbia, 20007, United States|University of Florida, Gainesville, Florida, 32610, United States|Clinical Research Specialists LLC, Kissimmee, Florida, 34746, United States|Advanced Pulmonary Research Institute, Loxahatchee Groves, Florida, 33470, United States|Piedmont Physicians Pulmonary & Sleep Medicine of Buckhead, Atlanta, Georgia, 30309, United States|The Emory Clinic, Atlanta, Georgia, 30322, United States|Northshore University Health System, Evanston, Illinois, 60201, United States|University of Kansas Medical Center, Kansas City, Kansas, 66160, United States|Tulane Medical Center, New Orleans, Louisiana, 70112, United States|Johns Hopkins Hospital, Baltimore, Maryland, 21224, United States|Massachusetts General Hospital, Boston, Massachusetts, 02114, United States|Brigham and Women's Hospital, Boston, Massachusetts, 02115, United States|St. Elizabeth's Medical Center, Boston, Massachusetts, 02135, United States|Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States|Corewell Health William Beaumont University Hospital, Royal Oak, Michigan, 48073, United States|University of Minnesota, Minneapolis, Minnesota, 55455, United States|Mayo Clinic, Rochester, Rochester, Minnesota, 55905, United States|The Lung Research Center, LLC, Chesterfield, Missouri, 63017, United States|Creighton University, Omaha, Nebraska, 68124, United States|Renown Regional Medical Center, Reno, Nevada, 89502, United States|Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, 03756, United States|Northern Westchester Hospital, Mount Kisco, New York, 10549, United States|Columbia University Medical Center-New York Presbyterian Hospital, New York, New York, 10032, United States|Duke University Medical Center, Durham, North Carolina, 27710, United States|Southeastern Research Center-Winston Salem-69289, Winston-Salem, North Carolina, 27103, United States|University of Cincinnati, Cincinnati, Ohio, 45267, United States|The Ohio State University Wexner Medical Center, Columbus, Ohio, 43210, United States|The Oregon Clinic, Portland, Oregon, 97220, United States|University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, United States|Temple University Hospital, Philadelphia, Pennsylvania, 19140, United States|Allegheny General Hospital, Pittsburgh, Pennsylvania, 15212, United States|Infinity Medical Research, Inc., East Providence, Rhode Island, 02914, United States|Lowcountry Lung and Critical Care, Charleston, South Carolina, 29406, United States|Clinical Trials Center of Middle Tennessee, LLC, Franklin, Tennessee, 37067, United States|Vanderbilt University Medical Center, Nashville, Tennessee, 37204, United States|Baylor University Medical Center, Dallas, Texas, 75246, United States|UT Health San Antonio, San Antonio, Texas, 78229, United States|Intermountain Medical Center-Murray-69497, Murray, Utah, 84107, United States|University of Vermont, Burlington, Vermont, 05401, United States|Inova Fairfax Hospital, Falls Church, Virginia, 22042, United States|Virginia Mason Medical Center, Seattle, Washington, 98101, United States|University of Wisconsin, Madison, Wisconsin, 53792, United States|Centro de Investigaciones Metabolicas (CINME)-C.A.B.A-61553, C.a.b.a, C1027AAP, Argentina|CEDIC - Centro de Investigacion Clinica, Caba, C1060ABN, Argentina|Hospital Italiano de Buenos Aires, Caba, C1199ABD, Argentina|Consultorios Médicos del Buen Ayre, Capital Federal, 1425, Argentina|INSARES, Mendoza, M5500CCG, Argentina|Canberra Hospital, Garran, Australian Capital Territory, 2605, Australia|Royal Prince Alfred Hospital, Camperdown, New South Wales, 2050, Australia|Lung Research Queensland, Chermside, Queensland, 4032, Australia|The Prince Charles Hospital, Chermside, Queensland, 4032, Australia|Austin Hospital, Heidelberg, Victoria, 3084, Australia|The Alfred Hospital, Melbourne, Victoria, 3004, Australia|Fiona Stanley Hospital, Murdoch, Western Australia, 6150, Australia|Trialswest, Spearwood, Western Australia, 6153, Australia|Macquarie University, Macquarie Park, 2109, Australia|LKH Salzburg University Hospital, Salzburg, 5020, Austria|AKH - Medical University of Vienna, Vienna, 1090, Austria|Klinik Penzing SMZ Baumgartner Hoehe, Vienna, 1140, Austria|Klinikum Wels - Grieskirchen GmbH, Wels, 4600, Austria|ULB Hopital Erasme, Bruxelles, 1070, Belgium|Brussels - UNIV Saint-Luc, Bruxelles, 1200, Belgium|UNIV UZ Gent, Gent, 9000, Belgium|UZ Leuven, Leuven, 3000, Belgium|Yvoir - UNIV UCL de Mont-Godinne, Yvoir, 5530, Belgium|Hospital das Clinicas da Universidade Federal HC-UFMG, Belo Horizonte,Minas Gerais, 31270901, Brazil|Edumed - Educacao e Saude SA, Curitiba, 80440-210, Brazil|CLARE - Clinica de Pneumologia, Goiania, 74110-030, Brazil|Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre, 90020-090, Brazil|Hospital Alemao Oswaldo Cruz, Sao Paulo, 01327-001, Brazil|CEMEC - Centro Multidisciplinar de Estudos Clínicos, S?o Bernardo do Campo, 09715-090, Brazil|University of Alberta Hospital (University of Alberta), Edmonton, Alberta, T6G 1Z1, Canada|Kelowna Respirology & Allergy Research, Kelowna, British Columbia, V1Y 3H5, Canada|St. Paul's Hospital (Vancouver), Vancouver, British Columbia, V1Y 1S1, Canada|Vancouver General Hospital, Vancouver, British Columbia, V5Z 1M9, Canada|Dr. Georges-L.-Dumont University Hospital Centre, Moncton, New Brunswick, E1C 2Z3, Canada|QEII Health Sciences Centre, Halifax, Nova Scotia, B3H 3A7, Canada|St. Joseph's Healthcare Hamilton, Hamilton, Ontario, L8N 1Y2, Canada|Dr. Syed Anees Medicine Professional Corporation, Windsor, Ontario, N8X 1T3, Canada|McGill University Health Centre (MUHC), Montreal, Quebec, H4A 3J1, Canada|CIC Mauricie Inc., Trois-Rivieres, Quebec, G8T 7A1, Canada|IUCPQ (Laval University), Quebec, G1V 4G5, Canada|Instituto Nacional del Tórax, Providencia, Santiago De Chile, 7500000, Chile|Centro de Investigación del Maule, Talca, 3465586, Chile|China-Japan Friendship Hospital, Beijing, 100029, China|The Second Xiangya Hospital Of Central South University, Changsha, 410011, China|West China Hospital, Chengdu, 610041, China|People's Hospital of Sichuan Province, Chengdu, 610072, China|First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China|Hangzhou First People's Hospital, Hangzhou, 310006, China|The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, 310009, China|Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China|The First hospital of Jiaxing, Jiaxing, 314000, China|Nanjing Drum Tower Hospital, Nanjing, 210008, China|The First Affiliated Hospital of Ningbo University, Ningbo, 315010, China|Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China|Shanghai Chest Hospital, Shanghai, 200030, China|Zhongshan Hospital Affiliated to Fudan University, Shanghai, 200032, China|China Shenyang Chest Hospital, Shenyang, 110000, China|Shenzhen People's Hospital, Shenzhen, 518020, China|The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China|Tianjin Medical University General Hospital, Tianjin, 30052, China|Wuhan Union Hospital, Wuhan, 430022, China|Tongji Hospital Affiliated Tongji Medical College Huazhong University of S & T, Wuhan, 430030, China|Renmin Hospital of Wuhan University, Wuhan, 430060, China|Wuxi People's Hospital, Wuxi, 214043, China|Affiliated Hospital, Xuzhou Medical college, Xuzhou, 221009, China|Yichang NO.1 People's Hospital, Yichang, 443000, China|University hospital center Zagreb, Zagreb, 10000, Croatia|University Hospital Dubrava, Zagreb, 10000, Croatia|Solmed Polyclinic, Zagreb, 1000, Croatia|Thomayer University Hospital, Praha 4, 140 59, Czechia|Gentofte Hospital, Hellerup, 2900, Denmark|Odense University Hospital, Odense C, 5000, Denmark|North Estonia Medical Centre Foundation, Tallinn, Tallinn, 13419, Estonia|HYKS Keuhkosairauksien tutkimusyksikk?, Helsinki, 00029, Finland|Oulun yliopistollinen keskussairaala, Oulu, 90220, Finland|HOP Avicenne, Bobigny, 93000, France|HOP de la Cavale Blanche, Brest, 29609, France|HOP Louis Pradel, Bron, 69677, France|HOP C?te de Nacre, Caen, 14033, France|HOP Michallon, La Tronche, 38700, France|HOP Bicêtre, Le Kremlin-Bicêtre, 94275, France|INS Coeur Poumon, Lille, 59037, France|HOP Nord, Marseille, 13915, France|HOP Nord Laennec, Nantes, 44093, France|HOP Pasteur, Nice, 06001, France|HOP Paris Saint-Joseph, Paris, 75014, France|HOP Européen G. Pompidou, Paris, 75015, France|HOP Bichat, Paris, 75877, France|HOP Haut-Lévêque, Pessac, 33604, France|HOP Robert Debré, Reims, 51100, France|HOP Pontchaillou, Rennes, 35033, France|HOP Charles Nicolle, Rouen, 76031, France|HOP Foch, Suresnes, 92151, France|HOP Larrey, Toulouse, 31059, France|National Center for Tuberculosis and Lung Diseases, Tbilisi, Tbilisi, 0101, Georgia|LLC Diacor, Tbilisi, 159, Georgia|Velocity Clinical Research Germany GmbH-Ahrensburg-69816, Ahrensburg, 22927, Germany|CIMS Studienzentrum Bamberg GmbH, Bamberg, 96049, Germany|Vivantes Netzwerk für Gesundheit GmbH, Berlin, 12351, Germany|Universit?tsklinikum Bonn A?R, Bonn, 53127, Germany|Fachkrankenhaus Coswig GmbH, Coswig, 01640, Germany|Ruhrlandklinik, Westdeutsches Lungenzentrum am Universit?tsklinikum Essen gGmbH, Essen, 45239, Germany|Universit?tsklinikum Hamburg, Eppendorf, Hamburg, 20246, Germany|Klinikum Region Hannover GmbH, Hannover, 30459, Germany|Medizinische Hochschule Hannover, Hannover, 30625, Germany|Thoraxklinik-Heidelberg gGmbH am Universit?tsklinikum Heidelberg, Heidelberg, 69126, Germany|Lungenfachklinik Immenhausen, Immenhausen, 34376, Germany|Klinikum der Universit?t München A?R, München, 81377, Germany|Krankenhaus Bethanien gGmbH, Solingen, 42699, Germany|Helios Hanseklinikum Stralsund, Stralsund, 18435, Germany|Robert Bosch Gesellschaft für medizinische Forschung mbH, Stuttgart, 70376, Germany|Universit?tsklinikum Tübingen, Tübingen, 72076, Germany|Hospital of Heraklion (PAGNI), Heraclion, 71110, Greece|General Hospital of Thessaloniki "Hippokrateio", Thessaloniki, 54642, Greece|Semmelweis University, Budapest, 1083, Hungary|Koranyi National Institute For Pulmonolgy, Budapest, 1121, Hungary|Bhatia Hospital, Mumbai, 400007, India|P.D. Hinduja National Hospital, Mumbai, 400067, India|Shamir Medical Center (Assaf Harofeh), Beer Yaakov, 7033001, Israel|Sourasky Medical Center, Tel Aviv, 6093246, Israel|A.O.U. Policlinico Vittorio Emanuele, Catania, 95124, Italy|A. O. Universitaria Careggi, Firenze, 50137, Italy|Ospedale Colonnello D Avanzo, Foggia, 71100, Italy|Ospedale G.B. Morgagni - L. Pierantoni AUSL Forlì, Forli', 47121, Italy|Osp. S. Giuseppe Fatebenefratelli, Milano, 20123, Italy|Università di Modena e Reggio Emilia, Modena, 41100, Italy|A.O. San Gerardo di Monza, Monza, 20052, Italy|Azienda Ospedaliera Universitaria di Padova, Padova, 35128, Italy|Poli Univ A. Gemelli, Roma, 00168, Italy|A.O.U. Senese Policlinico Santa Maria alle Scotte, Siena, 53100, Italy|Ospedali Riuniti di Ancona, Torrette Di Ancona (Ancona), 60126, Italy|Tosei General Hospital, Aichi, Seto, 489-8642, Japan|Chiba University Hospital, Chiba, Chiba, 260-8677, Japan|University of Fukui Hospital, Fukui, Yoshida-gun, 910-1193, Japan|National Hospital Organization Kyushu Medical Center, Fukuoka, Fukuoka, 810-8563, Japan|Kyushu University Hospital, Fukuoka, Fukuoka, 812-8582, Japan|Aso Co.,Ltd Iizuka Hospital, Fukuoka, Iizuka, 820-8505, Japan|Tsuboi Hospital, Fukushima, Koriyama, 963-0197, Japan|Hiroshima Prefectural Hospital, Hiroshima, Hiroshima, 734-8530, Japan|Sapporo Medical University Hospital, Hokkaido, Sapporo, 060-8543, Japan|National Hospital Organization Himeji Medical Center, Hyogo, Himeji, 670-8520, Japan|Kobe City Medical Center General Hospital, Hyogo, Kobe, 650-0047, Japan|Kobe City Hospital Organization Kobe City Medical Center West Hospital, Hyogo, Kobe, 653-0013, Japan|Kagawa University Hospital, Kagawa, Kita-gun, 761-0793, Japan|Kanagawa Cardiovascular and Respiratory Center, Kanagawa, Yokohama, 236-0051, Japan|Saiseikai Kumamoto Hospital, Kumamoto, Kumamoto, 861-4193, Japan|Nagasaki University Hospital, Nagasaki, Nagasaki, 852-8501, Japan|Kindai University Hospital, Osaka, Osakasayama, 589-8511, Japan|National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Sakai, 591-8555, Japan|Osaka Medical and Pharmaceutical University Hospital, Osaka, Takatsuki, 569-8686, Japan|Shimane University Hospital, Shimane, Izumo, 693-8501, Japan|Hamamatsu University Hospital, Shizuoka, Hamamatsu, 431-3192, Japan|Jichi Medical University Hospital, Tochigi, Shimotsuke, 329-0498, Japan|Tokushima University Hospital, Tokushima, Tokushima, 770-8503, Japan|Juntendo University Hospital, Tokyo, Bunkyo-ku, 113-8431, Japan|Toranomon Hospital, Tokyo, Minato-ku, 105-8470, Japan|Kyorin University Hospital, Tokyo, Mitaka, 181-8611, Japan|Toho University Omori Medical Center, Tokyo, Ota-ku, 143-8541, Japan|Keio University Hospital, Tokyo, Shinjuku-ku, 160-8582, Japan|Center Hospital of the National Center for Global Health and Medicine, Tokyo, Shinjuku-ku, 162-8655, Japan|Wakayama Medical University Hospital, Wakayama, Wakayama, 641-8510, Japan|The Catholic University of Korea, Bucheon St.Mary's Hospital, Bucheon, 14647, Korea, Republic of|Seoul National University Bundang Hospital, Seongnam, 13620, Korea, Republic of|Seoul National University Hospital, Seoul, 03080, Korea, Republic of|Severance Hospital, Seoul, 03722, Korea, Republic of|Soonchunhyang University Hospital Seoul, Seoul, 04401, Korea, Republic of|Asan Medical Center, Seoul, 05505, Korea, Republic of|Samsung Medical Center, Seoul, 135-710, Korea, Republic of|Hospital Sultan Idris Shah Serdang, Kajang, 43000, Malaysia|Institut Perubatan Respiratori, Kuala Lumpur, 53000, Malaysia|Centro de Investigacion Integral MEDIVEST S.C, Chihuahua, 31203, Mexico|Centro de Prevención y Rehabilitación de Enfermedades Pulmon, Monterrey, 64460, Mexico|Zuyderland Medisch Centrum, HEERLENHeerlen, 6419, Netherlands|Leids Universitair Medisch Centrum (LUMC), Leiden, 2333, Netherlands|St. Antonius ziekenhuis, locatie Nieuwegein, Nieuwegein, 3435 CM, Netherlands|Erasmus Medisch Centrum-ROTTERDAM-50697, Rotterdam, 3015, Netherlands|Waikato Hospital, Hamilton, 3204, New Zealand|Greenlane Clinical Centre, One Tree Hill, Auckland, 1051, New Zealand|Tauranga Hospital, Tauranga South, 3112, New Zealand|Haukeland Universitetssykehus, Bergen, N-5021, Norway|Oslo Universitetssykehus HF, Rikshospitalet, Oslo, 0372, Norway|University Clinical Center, Gdansk, Gdansk, 80-214, Poland|Leszek Giec Upper-Silesian Med.Cent.Silesian Med.Univ., Katowice, 40-635, Poland|Nat.Instit.of Tuberculosis&LungDiseases,Outpat.Clin,warszawa, Warsaw, 01-138, Poland|University Clinical Center of the Medical University of Warsaw, Warsaw, 02097, Poland|ULS Braga, Braga, 4710-243, Portugal|ULS de Coimbra, E.P.E., Coimbra, 3004-561, Portugal|ULS de S?o José, E.P.E., Lisboa, 1169-024, Portugal|USLM, EPE - Hospital Pedro Hispano, Matosinhos, 4454-509, Portugal|ULS de Gaia/Espinho, EPE, Vila Nova de Gaia, 4434-502, Portugal|Allianze Pulmonary Research LLC, Guaynabo, 00968, Puerto Rico|King Abdullah International Medical Research Center, Riyadh, 11481, Saudi Arabia|University Clinical Center of Serbia, Belgrade, 11000, Serbia|University Clinical Center of Kragujevac, Kragujevac, 34000, Serbia|University Clinical Center Nis, Nis, 18000, Serbia|Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, 21204, Serbia|Singapore General Hospital, Singapore, 169608, Singapore|Hospital Golnik - Univ. Clinic of Pulmonary and Allergic Diseases, Golnik, 4204, Slovenia|Enhancing Care Foundation NPC, Mount Edgecombe, 4301, South Africa|Hospital General Universitario de Alicante, Alicante, 03010, Spain|Hospital del Mar, Barcelona, 08003, Spain|Hospital Vall d'Hebron, Barcelona, 08035, Spain|Hospital de Basurto, Bilbao, 48013, Spain|Hospital de Galdakao, Galdakao, 48960, Spain|Hospital Universitario Virgen de las Nieves, Granada, 18014, Spain|Hospital de Bellvitge, L'Hospitalet de Llobregat, 08907, Spain|Hospital La Princesa, Madrid, 28006, Spain|Hospital General Universitario Gregorio Mara?ón, Madrid, 28007, Spain|Hospital Universitario Infanta Leonor, Madrid, 28031, Spain|Hospital Ramón y Cajal, Madrid, 28034, Spain|Hospital Universitario 12 de Octubre, Madrid, 28041, Spain|Hospital Virgen de la Victoria, Malaga, 29010, Spain|Hospital Central de Asturias, Oviedo, 33011, Spain|Hospital Son Espases, Palma de Mallorca, 07120, Spain|Hospital Quirónsalud Madrid, Pozuelo de Alarcón, 28223, Spain|Hospital Universitario Marqués de Valdecilla, Santander, 39008, Spain|Hospital Clínico de Santiago, Santiago de Compostela, 15706, Spain|Hospital Virgen del Rocío, Sevilla, 41013, Spain|Hospital Nuestra Se?ora de Valme, Sevilla, 41014, Spain|Hospital General Universitario de Valencia, Valencia, 46014, Spain|Universitetssjukhuset, Link?ping, Link?ping, 581 85, Sweden|Akademiska sjukhuset, Uppsala, 75185, Sweden|Chang-Hua Christian Hospital, Changhua, 500, Taiwan|Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, 807, Taiwan|Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 83301, Taiwan|Taichung Veterans General Hospital, Taichung, 407, Taiwan|NCKUH, Tainan, 704, Taiwan|Taipei Veterans General Hospital, Taipei, 11217, Taiwan|Siriraj Hospital, Bangkok Noi, 10700, Thailand|Srinagarind Hospital, Khon Kaen, 40002, Thailand|Maharat Nakhonchiangmai Hospital, Muang, 50200, Thailand|Ramathibodi Hospital, Ratchatewi, 10400, Thailand|Songklanagarind Hospital, Songkhla, 90110, Thailand|Gulhane Training and Research Hospital, Ankara, 06010, Turkey|Ankara Universitesi Tip Fakultesi, Ankara, 06620, Turkey|Akdeniz Universitesi Tip Fakultesi -ANTALYA-33606, Antalya, 07070, Turkey|Istanbul Universitesi Istanbul Tip Fakultesi, Istanbul, 34390, Turkey|Gazi Universitesi Tip Fakultesi, Yenimahalle/ANKARA, 06560, Turkey|Queen Elizabeth Hospital Birmingham, Birmingham, B15 2GW, United Kingdom|Southmead Hospital, Bristol, BS10 5NB, United Kingdom|Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom|Royal Devon and Exeter Hospital, Wonford, Exeter, EX2 5DW, United Kingdom|Royal Lancaster Infirmary, Lancaster, LA1 4RP, United Kingdom|St James's University Hospital, Leeds, LS9 7TF, United Kingdom|Altnagelvin Area Hospital, Londonderry, BT47 6SB, United Kingdom|Royal Brompton Hospital, London, SW3 6NP, United Kingdom|Wythenshawe Hospital, Manchester, M23 9QZ, United Kingdom|Churchill Hospital, Oxford, OX3 7LE, United Kingdom|Southampton General Hospital, Southampton, SO16 6YD, United Kingdom Less << |
NCT05718648 | Renal Insufficiency|Healthy | PHASE1 | COMPLETED | 2023-08-15 | CRS Clinical Research Services... More >> Kiel GmbH, Kiel, 24105, Germany Less << |
NCT05633862 | Healthy | PHASE1 | COMPLETED | 2023-03-17 | Peking Union Medical College H... More >>ospital, Beijing, 100032, China Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.23mL 0.45mL 0.22mL |
11.14mL 2.23mL 1.11mL |
22.27mL 4.45mL 2.23mL |
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Dissolving Methods |
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
|