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CAS No. :	1374516-07-0
Formula :	C₂₃H₂₁FO₃
M.W :	364.41
SMILES Code :	O=C(O)CCC1=CC=C(OCC2=CC(F)=CC=C2C3=CC=C(C)C=C3)C=C1
MDL No. :	MFCD22421654
InChI Key :	LPGBXHWIQNZEJB-UHFFFAOYSA-N
Pubchem ID :	57522038

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

BMMSCs	0.5 µM	3 days	Low concentrations of TUG-891 elevated P38 and increased adipogenesis	Sci Rep. 2015 Sep 14;5:14080
Mouse colonic mucosal cells	300 nM	10–15 minutes	To compare the pharmacology of FFA1 and FFA4 agonists, finding selective agonists more potent than GW9508	Br J Pharmacol. 2017 Dec;174(23):4508-4522.
DU145 cells	1 µM	15 minutes	Inhibits LPA-induced p70S6K phosphorylation	J Pharmacol Exp Ther. 2015 Feb;352(2):380-94
Brown adipocytes	10 µM	10 minutes	To investigate the effect of TUG-891 on mitochondrial membrane potential, results showed that TUG-891 caused mitochondrial depolarization.	EMBO Mol Med. 2018 Mar;10(3):e8047
BMMSCs	50 µM	14 days	High concentrations of TUG-891 promoted osteogenesis via the Ras-ERK1/2 cascade	Sci Rep. 2015 Sep 14;5:14080
MPC5 podocytes	10 µM	24 hours	To evaluate the protective effect of TUG-891 on high glucose-induced podocyte injury. Results showed that TUG-891 significantly suppressed the high glucose-induced increases in fibronectin, collagen IV, α-SMA, TGF-β1, and IL-6 expression, and reduced the phosphorylation of TAK1, IKKβ, NF-κB p65, JNK, and p38 MAPK.	Acta Pharmacol Sin. 2021 Feb;42(2):252-263
Bovine granulosa cells	1, 10, 50 µM	24 hours	DHA (10 and 50 μM) significantly increased cell proliferation; TUG-891 (1 and 50 μM) also increased cell proliferation	Reprod Biol Endocrinol. 2018 Apr 26;16(1):40
Bovine cumulus cells	1 µM or 5 µM	24 hours	Investigate the effect of TUG-891 on cumulus cells, results showed TUG-891 treatment increased blastocyst rate	J Ovarian Res. 2017 Nov 9;10(1):74
RAW264.7 murine macrophages	100 µM	24 hours	To assess the effects of TUG-891 on ROS-related protein expression, results showed increased Nrf2 nuclear translocation and HO-1 and NQO1 expression, and decreased Nox1 expression.	Int J Mol Sci. 2021 Sep 29;22(19):10544
Brown adipocytes	10 µM	30 minutes	To evaluate the effect of TUG-891 on the oxygen consumption rate (OCR) of brown adipocytes, results showed that TUG-891 significantly increased OCR.	EMBO Mol Med. 2018 Mar;10(3):e8047
RAW264.7 murine macrophages	20–100 µM	48 hours	To test the effects of TUG-891 on cell viability, results showed no effect on cell viability at all concentrations tested.	Int J Mol Sci. 2021 Sep 29;22(19):10544
RAW264.7 murine macrophages	20–100 µM	5 days	To evaluate the effects of TUG-891 on osteoclast formation, results showed significant reduction in osteoclast formation.	Int J Mol Sci. 2021 Sep 29;22(19):10544
PC-3 cells	1 µM	6 hours	Inhibits LPA- and EGF-induced cell migration	J Pharmacol Exp Ther. 2015 Feb;352(2):380-94
RAW264.7 cells	3 µM	60 minutes	TUG-891, as a selective agonist of GPR120, could reproduce the effect of EPA in RAW264.7 cells, suppressing LPS-induced Ccl2 expression.	J Neuroinflammation. 2020 Apr 24;17(1):129

ICR mice and C57BL/6 mice	Normal ICR mice and diet-induced obese (DIO) mice	Oral administration	10, 20, 30, and 100 mg/kg	Single dose	Evaluate the hypoglycemic effect of TUG-891 in normal mice and DIO mice, results showed TUG-891 could reduce blood glucose levels in a dose-dependent manner and exhibited good anti-hyperglycemic effects in DIO mice	Molecules. 2021 Nov 16;26(22):6907
C57BL/6 mice	Ovariectomized model	Bone marrow cavity injection	10, 30, 50 μmol/kg	Three times per week for 10 weeks	High doses of TUG-891 rescued oestrogen-deficient bone loss in vivo	Sci Rep. 2015 Sep 14;5:14080
Mice	Wild-type mice	Lingual application	100 μM	Single dose, monitored for 30 min	TUG891 activated the tongue-brain-gut axis, increased pancreatobiliary secretions, reduced circulating LDL, and modulated fat preference.	J Lipid Res. 2020 Feb;61(2):133-142
ICR mice	Normal ICR mice	Oral	20 mg/kg	Single dose	Evaluate the effect of TUG-891 on oral glucose tolerance in normal ICR mice	Int J Mol Sci. 2024 Oct 25;25(21):11476
ApoE-knockout mice	High-fat diet-induced liver steatosis model	Subcutaneous injection	20 mg/kg	Three times a week for 16 weeks	To evaluate the effect of TUG-891 on liver steatosis, results showed that TUG-891 inhibited the progression of liver steatosis, reduced TG accumulation in the liver, and decreased plasma AST levels.	Cardiovasc Drugs Ther. 2024 Aug;38(4):667-678
ApoE-knockout mice	Atherosclerosis model	Subcutaneous injection	20 mg/kg	Three times a week for 4 months	TUG-891 administration has led to the reduction of atherosclerotic plaque size and necrotic cores in an apoE-knockout mice model. TUG-891-treated mice were administered subcutaneously at a dose of 20 mg/kg three times a week for 4 months. The FFAR4 agonist reduced the content of pro-inflammatory M1-like macrophages content in atherosclerotic plaques, as evidenced by immunohistochemical phenotyping and molecular methods. In atherosclerotic plaque, the population of smooth muscle cells increased as evidenced by α-SMA staining. We observed changes in G-CSF and eotaxin markers in the plasma of mice; changes in the levels of these markers in the blood may be related to macrophage differentiation. Importantly, we observed a significant increase in M2-like macrophage cells in atherosclerotic plaque and peritoneum.	Int J Mol Sci. 2021 Sep 9;22(18):9772
Rats	Type 1 diabetes model rats	Oral	20 mg/kg	Single dose, immediately before glucose load	TUG-891, a GPR120 agonist, ameliorated postprandial hyperglycemia but TAK-875, a GPR40 agonist, did not.	Front Pharmacol. 2023 Jul 31;14:1197743
Mice	Db/db diabetic mice model	Gavage	35 mg/kg	Once daily for 4 weeks	To evaluate the protective effect of TUG-891 on diabetic nephropathy. Results showed that TUG-891 significantly improved urinary albumin excretion, protected against podocyte injury, reduced collagen deposition in the glomerulus, and inhibited the mRNA and protein expression of fibronectin, collagen IV, α-SMA, TGF-β1, and IL-6. Additionally, TUG-891 downregulated the phosphorylation of Smad3 and STAT3, alleviating glomerulosclerosis.	Acta Pharmacol Sin. 2021 Feb;42(2):252-263
C57Bl/6J mice	Wild-type and GPR120 knockout mice	Intraperitoneal injection	35 mg/kg	Once daily for 2.5 weeks	To evaluate the effect of TUG-891 on body weight and fat oxidation, results showed that TUG-891 reduced body weight and fat mass, and increased fat oxidation.	EMBO Mol Med. 2018 Mar;10(3):e8047
C57BL/6 mice	Intraventricular hemorrhage model	Intraperitoneal injection	35 mg/kg	Once at 1, 24, and 48 hours	TUG-891 protects neurons by inhibiting endoplasmic reticulum stress and pyroptosis, improving neurological function	Neural Regen Res. 2023 Oct;18(10):2278-2284
Mice	Cisplatin-induced acute kidney injury model	Oral gavage	35 mg/kg/day	Once daily for six days	To investigate the effect of TUG-891 on cisplatin-induced acute kidney injury, results showed that TUG-891 improved renal function and pathological damage, and reduced the expression of cellular senescence markers	Signal Transduct Target Ther. 2022 Nov 30;7(1):384
Rats	PCOS-IR rat model	Intraperitoneal injection	9.1 × 6.3/kg /day	Once daily for four weeks	TUG-891 improved insulin resistance and chronic inflammation in PCOS-IR rats by upregulating GPR120 expression	Int J Mol Sci. 2024 Oct 17;25(20):11146

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CAS No.: 1374516-07-0

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CAS No.: 1374516-07-0

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Precautionary Statements-General

Prevention

Response

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Physical hazards

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	2.74mL 0.55mL 0.27mL	13.72mL 2.74mL 1.37mL	27.44mL 5.49mL 2.74mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed