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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 440122-66-7 Chemical Structure| 440122-66-7

Structure of WAY-200070
CAS No.: 440122-66-7

Chemical Structure| 440122-66-7

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WAY200070 selectively activates ERβ (EC50 = 2 nM) receptor over ERα (EC50 = 155 nM). It shows anti-depressive and anti-anxiolytic activities.

Synonyms: WAY-00005

4.5 *For Research Use Only !

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Product Details of WAY-200070

CAS No. :440122-66-7
Formula : C13H8BrNO3
M.W : 306.11
SMILES Code : OC1=CC(Br)=C(OC(C2=CC=C(O)C=C2)=N3)C3=C1
Synonyms :
WAY-00005
MDL No. :MFCD16618385
InChI Key :BAAILVWEAXFTSF-UHFFFAOYSA-N
Pubchem ID :135418373

Safety of WAY-200070

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H319
Precautionary Statements:P301+P310-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Mouse islets 100 pM 1 hour WAY200070 enhanced glucose-stimulated insulin secretion Diabetes. 2013 Jun;62(6):2015-25
Primary cultured human keratinocytes 1 µM 24 hours WAY-200070 significantly increased CAMP mRNA and protein expression J Nutr Biochem. 2014 Jul;25(7):734-40
HaCaT keratinocytes 1 µM 24 hours WAY-200070 significantly increased CAMP mRNA and protein expression J Nutr Biochem. 2014 Jul;25(7):734-40
Cultured cortical neurons 10 nM 30-60 minutes Activation of ERβ resulted in increased spine density and PSD-95 accumulation in membrane regions J Neurosci. 2010 Oct 6;30(40):13454-60
GLUTag cells 10 nM 48 hours To evaluate the effect of E2 on GLP-1 secretion in GLUTag cells, results showed that only ERβ activation increased GLP-1 secretion. JCI Insight. 2018 Apr 5;3(7):e98569
Human α cells 10 nM 48 hours To evaluate the effect of E2 on GLP-1 secretion in human α cells, results showed that E2 increased GLP-1 secretion through activation of all three estrogen receptors (ERα, ERβ, and GPER). JCI Insight. 2018 Apr 5;3(7):e98569
Mouse α cells 10 nM 48 hours To evaluate the effect of E2 on GLP-1 secretion in α cells, results showed that E2 increased GLP-1 secretion through activation of all three estrogen receptors (ERα, ERβ, and GPER). JCI Insight. 2018 Apr 5;3(7):e98569

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice OVX chronic epileptic mouse model Subcutaneous injection 10 mg/kg Once daily for one week WAY-200070 markedly suppressed epileptic phenotypes and normalized GLUL expression in CA1 region of KA-induced OVX chronic epileptic model. Theranostics. 2021 Apr 7;11(12):6074-6089
Mice C57BL/6 mice Intraperitoneal injection 10 mg/kg Single administration WAY200070 improved glucose tolerance and increased plasma insulin levels Diabetes. 2013 Jun;62(6):2015-25
Female Sprague-Dawley rats Ovariectomized and intact female rats Subcutaneous injection 10 mg/kg Single injection, tested 4 hours later Tested the effect of ERβ selective agonist WAY200070 on a visceral pain model, showing significant attenuation of the visceromotor response four hours after injection. J Pain. 2012 Jul;13(7):685-94
Mice Ovariectomized mice Subcutaneous injection 10 mg/kg/day Once daily for 48 hours To evaluate the effect of WAY-200070 on glucose tolerance in ovariectomized mice, results showed that WAY-200070 improved glucose tolerance by increasing plasma GLP-1 levels. JCI Insight. 2018 Apr 5;3(7):e98569
C57BL/6J mice Mixed allergen (MA)-induced asthma model Subcutaneous implantation 4.17 mg/d Sustained release, daily release To evaluate the effect of the ER β-specific agonist WAY-200070 on airway hyperresponsiveness and remodeling in an asthma model. Results showed that WAY-200070 significantly reversed MA-induced increases in airway resistance, decreases in compliance, and airway remodeling, with more pronounced effects observed in female mice. Am J Respir Cell Mol Biol. 2019 Oct;61(4):469-480

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.27mL

0.65mL

0.33mL

16.33mL

3.27mL

1.63mL

32.67mL

6.53mL

3.27mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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