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Chemical Structure| 79127-24-5 Chemical Structure| 79127-24-5

Structure of A-7 HCl
CAS No.: 79127-24-5

Chemical Structure| 79127-24-5

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A-7 HCl is a potent calmodulin antagonist.

Synonyms: Ophobolin A; A-7 (hydrochloride)

4.5 *For Research Use Only !

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Product Details of A-7 HCl

CAS No. :79127-24-5
Formula : C20H29ClN2O2S.HCl
M.W : 433.44
SMILES Code : Cl.NCCCCCCCCCCNS(=O)(=O)C1=C2C=CC=C(Cl)C2=CC=C1
Synonyms :
Ophobolin A; A-7 (hydrochloride)
MDL No. :MFCD00209822

Safety of A-7 HCl

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00796302 - Completed - -
NCT00150592 Attention Deficit Disorder Wit... More >>h Hyperactivity Less << Phase 2 Completed - -
NCT00150592 - Completed - -
NCT00796302 Attention Deficit Disorder Wit... More >>h Hyperactivity Less << Phase 4 Completed - United States, New York ... More >> State University of New York Stony Brook Stony Brook, New York, United States, 11794 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 Ohio State University Nisonger Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT00937040 Attention Deficit Disorder Wit... More >>h Hyperactivity Less << Phase 4 Completed - -
NCT01012622 Attention Deficit Disorder Wit... More >>h Hyperactivity Less << Phase 4 Completed - -
NCT03710642 Alzheimer's Disease ... More >> Disruptive Behavior Less << Phase 2 Recruiting December 31, 2022 United States, California ... More >> University of Southern California Not yet recruiting Los Angeles, California, United States, 90033 University of California, San Diego (UCSD) Not yet recruiting San Diego, California, United States, 92093 Stanford University Not yet recruiting Stanford, California, United States, 94305 United States, Kentucky University of Kentucky Recruiting Lexington, Kentucky, United States, 40506 Contact: Amir Elbiheary    859-218-3775    ael243@uky.edu    Principal Investigator: Ronan Murphy, MD          United States, South Carolina Roper St. Francis Not yet recruiting Charleston, South Carolina, United States, 29401 United States, Texas University of Texas, Southwestern MC at Dallas Not yet recruiting Dallas, Texas, United States, 75390 United States, Washington University of Washington Not yet recruiting Seattle, Washington, United States, 98108 Less <<
NCT00937040 - Completed - -
NCT01012622 - Completed - -
NCT00833794 - Completed - -
NCT00478881 Overactive Bladder ... More >> Detrusor Overactivity Less << Phase 2 Completed - -
NCT00478881 - Completed - -
NCT00833794 Pain Osteoart... More >>hritis Less << Phase 3 Completed - -
NCT01614912 Schizophrenia Phase 3 Completed - Japan ... More >> 69 Sites Tokyo, Etc, Japan Korea, Republic of 22 Sites Seoul, Etc, Korea, Republic of Malaysia 10 Sites Kuala Lumpur, Etc, Malaysia Taiwan 14Sites Taipei, Etc, Taiwan Less <<
NCT01614912 - Completed - -
NCT01192295 - Completed - -
NCT01081132 Attention-Deficit/Hyperactivit... More >>y Disorder Less << Phase 3 Completed - -
NCT01614899 - Completed - -
NCT01006356 Cancer Pain Phase 4 Completed - -
NCT01192295 Pain Phase 3 Completed - -
NCT01006356 - Completed - -
NCT01081132 - Completed - -
NCT00799487 Attention Deficit Hyperactivit... More >>y Disorder Less << Phase 4 Completed - -
NCT00799409 Attention Deficit Hyperactivit... More >>y Disorder Less << Phase 4 Completed - United States, California ... More >> Irvine, California, United States United States, Texas Houston, Texas, United States Less <<
NCT00799409 - Completed - -
NCT01675167 Low Back Pain Phase 3 Completed - -
NCT01675167 - Completed - -
NCT00799487 - Completed - -
NCT01081145 Attention-deficit/Hyperactivit... More >>y Disorder Less << Phase 3 Completed - -
NCT01081145 - Completed - -
NCT01633944 - Completed - -
NCT02115906 - Unknown May 2018 Austria ... More >> Medical University Of Vienna, Department of Internal Medicine III Recruiting Vienna, Austria, 1090 Contact: Peter Wolf, MD    00431404004311    peter.wolf@meduniwien.ac.at    Principal Investigator: Michael Krebs, MD, Prof Less <<
NCT03500094 Fabry Disease Phase 3 Recruiting September 1, 2020 United States, Florida ... More >> University of South Florida Recruiting Tampa, Florida, United States, 33606 United States, Georgia Emory University Division of Medical Genetics Recruiting Decatur, Georgia, United States, 30033 United States, Missouri University of Missouri Recruiting Columbia, Missouri, United States, 65201 United States, Ohio Cincinnati Children's Hospital Not yet recruiting Cincinnati, Ohio, United States, 45229 United States, Pennsylvania Children's Hospital of Philadelphia Not yet recruiting Philadelphia, Pennsylvania, United States, 19104 Children's Hospital of Pittsburgh of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15224 United States, Virginia Lysosomal & Rare Disorders Research & Treatment Center Recruiting Fairfax, Virginia, United States, 22030 Less <<
NCT01614899 Schizophrenia Phase 3 Completed - Japan ... More >> 69 Sites Tokyo, Etc, Japan Korea, Republic of 22 Sites Seoul, Etc, Korea, Republic of Malaysia 10 Sites Kuala Lumpur, Etc, Malaysia Taiwan 14 Sites Taipei, Etc, Taiwan Less <<
NCT03393026 Schizophrenia Phase 4 Recruiting August 2019 Taiwan ... More >> Taipei City Hospital, Songde Branch Recruiting Taipei, Taiwan Contact: Shih-Ku Lin, M.D.    (02)2726-3141       Tri-Service General Hospital Recruiting Taipei, Taiwan Contact: Chin-Bin Yeh, M.D., Ph.D.    886-2-87923311 Less <<
NCT03560349 Post-Dural Puncture Headache Phase 2 Enrolling by invitation June 30, 2020 United States, Utah ... More >> University of Utah Salt Lake City, Utah, United States, 84132 Less <<
NCT01633944 Low Back Pain Phase 3 Completed - -
NCT00322205 Smoking Cessation Phase 4 Completed - United States, New York ... More >> State University of New York Buffalo, New York, United States Less <<
NCT01060150 - Completed - -
NCT01060150 Attention Deficit Disorder Wit... More >>h Hyperactivity Less << Phase 4 Completed - -
NCT03396250 Pain Phase 1 Completed - United States, Texas ... More >> ICON Development Solutions, LLC San Antonio, Texas, United States, 78219 Less <<
NCT03424135 Pain Phase 1 Completed - United States, Texas ... More >> ICON Development Solutions, LLC San Antonio, Texas, United States, 78219 Less <<
NCT01500694 - Completed - -
NCT01106430 Attention-Deficit/Hyperactivit... More >>y Disorder Less << Phase 3 Completed - -
NCT03539952 Wilson Disease Phase 3 Recruiting March 2021 United States, Connecticut ... More >> Yale University School of Medicine Recruiting New Haven, Connecticut, United States, 06510 Contact: Ricarda Tomlin       ricarda.tomlin@yale.edu    Germany Innere Medizin Recruiting Heidelberg, Germany, 69120 Contact: Andrea Langel    49 6221-56 8388    andrea.langel@med.uni-heidelberg.de    Contact: Jessica Langel       jessica.langel@med.uni-heidelberg    Poland Institute of Psychiatry and Neurology Recruiting Warsaw, Poland, 02 957 Contact: Beata Ziółkowska    48 2245 82 609    ziolko275@wp.pl Less <<
NCT00663117 Inflammation ... More >>Crohn's Disease Less << Phase 2 Completed - United States, Pennsylvania ... More >> Penn State Hershey Medical Center Hershey, Pennsylvania, United States, 17033 Less <<
NCT01500694 Attention Deficit Hyperactivit... More >>y Disorder (ADHD) Less << Phase 3 Completed - -
NCT01106430 - Completed - -
NCT01322282 Allergy Phase 1 Completed - Canada, Quebec ... More >> Algorithme Pharma Inc. Mount-Royal, Quebec, Canada, H3P 3P1 Less <<
NCT00663117 - Completed - -
NCT00005669 Hyperinsulinemia ... More >> Obesity Less << Phase 2 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT00715988 Pain Phase 1 Completed - United States, Utah ... More >> University of Utah Salt Lake City, Utah, United States, 84108 Primary Children's Medical Center Salt Lake City, Utah, United States, 84113 Less <<
NCT00005669 - Completed - -
NCT00306735 Multiple Myeloma Phase 2 Completed - United States, Indiana ... More >> Indiana Blood and Marrow Transplantation Beech Grove, Indiana, United States, 46107 United States, New York Cornell Medical Center New York, New York, United States, 10021 United States, North Carolina Wake Forest Medical Center Winston-Salem, North Carolina, United States, 27157 United States, Oregon Oregon Health & Science University Portland, Oregon, United States, 97239 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Fox Chase-Temple Philadelphia, Pennsylvania, United States, 19111 United States, Texas Baylor University Blood and Marrow Transplantation Dallas, Texas, United States, 75246 MD Anderson Cancer Center Houston, Texas, United States, 77030 Texas Transplant Institute San Antonio, Texas, United States, 78229 United States, Virginia Fairfax-Northern Virginia Hematology-Oncology PC Fairfax, Virginia, United States, 22031 Less <<
NCT02015234 - Completed - -
NCT01863186 Opioid Dependence ... More >> Acute Opioid Withdrawal Syndrome Less << Phase 3 Completed - United States, California ... More >> Clovis, California, United States, 93611 Escondido, California, United States, 92025 San Diego, California, United States United States, Florida Miami, Florida, United States, 33136 Orlando, Florida, United States, 32806 United States, Georgia Atlanta, Georgia, United States, 30308 United States, Illinois Oak Park, Illinois, United States, 60301 United States, Louisiana Lake Charles, Louisiana, United States, 70629 United States, Maryland Baltimore, Maryland, United States, 21229 United States, Mississippi Flowood, Mississippi, United States United States, Missouri Saint Louis, Missouri, United States United States, Ohio Dayton, Ohio, United States Mason, Ohio, United States, 45050 United States, Texas Austin, Texas, United States, 78731 Dallas, Texas, United States, 75208 DeSoto, Texas, United States, 75115 United States, Utah Orem, Utah, United States, 84058 Salt Lake City, Utah, United States, 84106 Less <<
NCT02015234 Primary Fibromyalgia Phase 3 Completed - United States, Colorado ... More >> Denver Denver, Colorado, United States, 80239 United States, Florida 16176 Cortez Boulevard Brooksville, Florida, United States, 34601 100 West Gore Street Orlando, Florida, United States, 32806 United States, Maryland 71 Thomas Johnson Drive Frederick, Maryland, United States, 21702 United States, Massachusetts 370 Faunce Corner Road North Dartmouth, Massachusetts, United States, 02747 Worcester Worcester, Massachusetts, United States, 01605 United States, Mississippi Jackson Jackson, Mississippi, United States, 39202 United States, Ohio Cincinnati Cincinnati, Ohio, United States, 45219 1275 Olentangy River Road Columbus, Ohio, United States, 43212 18660 Bagley Road Middleburg Heights, Ohio, United States, 44130 United States, Pennsylvania 1001 South Market Street Mechanicsburg, Pennsylvania, United States, 17055 United States, South Carolina 322 Memorial Drive Greer, South Carolina, United States, 29650 United States, Washington 601 Broadway Seattle, Washington, United States, 98122 Less <<
NCT00790192 Schizophrenia Phase 3 Completed - -
NCT01466647 Non Small Cell Lung Cancer Phase 1 Completed - Sweden ... More >> KFUE Uppsala, Sweden University Hospital Uppsala, Sweden Less <<
NCT00790192 - Completed - -
NCT01221740 Back Pain Phase 3 Withdrawn(Company decided to d... More >>iscontinue) Less << - United States, Massachusetts ... More >> Brigham and Women's Hospital Pain Trials Center Chestnut Hill, Massachusetts, United States, 02467 Less <<
NCT00874120 Blood Pressure ... More >> Human Experimentation Less << Phase 3 Completed - -
NCT03465787 Schizophrenia Phase 3 Recruiting April 2019 Korea, Republic of ... More >> Borame Medical Center Recruiting Seoul, Seoul, Dongjak-gu, Korea, Republic of, 07061 Contact: Jung Hee Yeon    82-2-870-2461    hyjung@snu.ac.kr    Principal Investigator: Jung Hee Yeon, M.D. Less <<
NCT00615433 Schizophrenia Phase 3 Completed - -
NCT00615433 - Completed - -
NCT00549718 - Completed - -
NCT02597257 Postherpetic Neuralgia ... More >> Diabetic Polyneuropathy Peripheral Neuropathy Less << Phase 2 Unknown July 2016 Korea, Republic of ... More >> Yong Chul Kim Recruiting Seoul, Korea, Republic of Contact: Yong Chul Kim, PhD    +82-2-2072-3289    pain@snu.ac.kr    Sub-Investigator: Jee Youn Moon, PhD Less <<
NCT00549718 Schizophrenia Phase 3 Completed - -
NCT00254878 ADHD Phase 3 Completed - Germany ... More >> Novartis Investigational Site Freiburg, Germany Less <<
NCT00874120 - Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.31mL

0.46mL

0.23mL

11.54mL

2.31mL

1.15mL

23.07mL

4.61mL

2.31mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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