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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 1170613-55-4 Chemical Structure| 1170613-55-4

Structure of A-967079
CAS No.: 1170613-55-4

Chemical Structure| 1170613-55-4

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A 967079 is a selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively).

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Details of A-967079

CAS No. :1170613-55-4
Formula : C12H14FNO
M.W : 207.24
SMILES Code : CCC(/C(C)=C/C1=CC=C(F)C=C1)=N\O
MDL No. :MFCD20488058

Safety of A-967079

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H228-H302-H317-H319-H341-H351
Precautionary Statements:P280-P210-P240-P264-P270-P301+P310-P330-P370+P378-P403+P233-P405-P501
Class:4.1
UN#:1325
Packing Group:

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
mouse brain slices 1 μM 45 min To investigate the role of TRPA1 in regulating cortical susceptibility to CSD, results showed that A-967079 reversed H2O2-facilitated submaximal CSD induction J Headache Pain. 2019 Mar 6;20(1):25

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice Neuropathic pain model Local injection 16 µg/20 µl Single administration Evaluate the antinociceptive effect of A-967079 in the AITC test and formalin test. Results showed that A-967079 reduced pain reaction by 48% in the AITC test and by 54% in the early phase of the formalin test. J Zhejiang Univ Sci B. 2015 Mar;16(3):167-78

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.83mL

0.97mL

0.48mL

24.13mL

4.83mL

2.41mL

48.25mL

9.65mL

4.83mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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