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Chemical Structure| 450839-40-4 Chemical Structure| 450839-40-4

Structure of ABT-100
CAS No.: 450839-40-4

Chemical Structure| 450839-40-4

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ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibited proliferation of cells in vitro carrying oncogenic H-Ras (EJ-1 bladder; IC(50) 2.2 nmol/L), Ki-Ras (DLD-1 colon, MDA-MB-231 breast, HCT-116 colon, and MiaPaCa-2 pancreatic; IC(50) range, 3.8-9.2 nmol/L), and wild-type Ras (PC-3 and DU-145; IC(50), 70 and 818 nmol/L, respectively) as well as clonogenic potential. ABT-100 shows 70% to 80% oral bioavailability in mice. ABT-100 regressed EJ-1 tumors (2-12.5 mg/kg/d s.c., every day for 21 days) and showed significant efficacy in DLD-1, LX-1, MiaPaCa-2, or PC-3 tumor-bearing mice (6.25-50 mg/kg/d s.c. once daily or twice daily orally).

Synonyms: ABT-100

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Product Details of ABT-100

CAS No. :450839-40-4
Formula : C27H19F3N4O3
M.W : 504.46
SMILES Code : [C@](COC1=C(C=C(C#N)C=C1)C2=CC=C(OC(F)(F)F)C=C2)(O)(C3=CC=C(C#N)C=C3)C=4N(C)C=NC4
Synonyms :
ABT-100

Safety of ABT-100

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1 mM

5 mM

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1.98mL

0.40mL

0.20mL

9.91mL

1.98mL

0.99mL

19.82mL

3.96mL

1.98mL

 

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