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Chemical Structure| 1266084-51-8 Chemical Structure| 1266084-51-8

Structure of Acoziborole
CAS No.: 1266084-51-8

Chemical Structure| 1266084-51-8

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SCYX-7158 is an effective, safe and orally active treatment for human african trypanosomiasis (HAT). In the T. b. brucei S427 strain, the MIC value for SCYX-7158 is 0.6 µg/mL.

Synonyms: SCYX-7158; AN5568; Oxaborole

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Product Details of Acoziborole

CAS No. :1266084-51-8
Formula : C17H14BF4NO3
M.W : 367.10
SMILES Code : O=C(NC1=CC=C2C(C)(C)OB(O)C2=C1)C3=CC=C(F)C=C3C(F)(F)F
Synonyms :
SCYX-7158; AN5568; Oxaborole
MDL No. :MFCD30532746

Safety of Acoziborole

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
Acoziborole (SCYX-7158) is identified as a potent, safe, and orally administrable antiprotozoal compound, which holds promise for the study and potential treatment of Human African Trypanosomiasis (HAT). Specifically against the Trypanosoma brucei brucei S427 strain, SCYX-7158 exhibits a minimal inhibitory concentration (MIC) value of 0.6 µg/mL, highlighting its effectiveness against this parasitic disease[1].

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT05433350 Trypanosomiasis, African|Trypa... More >>nosoma Brucei Gambiense; Infection|Sleeping Sickness Less << PHASE2|PHASE3 UNKNOWN 2024-06-30 H?pital Général de Dipumba, Mb... More >>uji-Mayi, Kasai-Oriental, Congo, The Democratic Republic of the|CDTC Katanda, Katanda, Kasa?-Oriental, Congo, The Democratic Republic of the|HGR Bagata, Bagata, Kwilu, Congo, The Democratic Republic of the|Hospital of Masi-Manimba, Masi-Manimba, Kwilu, Congo, The Democratic Republic of the|General Hospital of Bandundu, Bandundu, Congo, The Democratic Republic of the Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.72mL

0.54mL

0.27mL

13.62mL

2.72mL

1.36mL

27.24mL

5.45mL

2.72mL

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