Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

CAS No. :	1375465-91-0
Formula :	C₁₄H₁₄N₄O₂
M.W :	270.29
SMILES Code :	O=C(C1=CN=C(NC2(C3=CC=CC=C3)CC2)N=C1)NO
MDL No. :	MFCD28347706
InChI Key :	LIIWIMDSZVNYHY-UHFFFAOYSA-N
Pubchem ID :	57381425

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

N2a cells	3μM		ACY-738 significantly increased acetylation levels of α-tubulin and histone 3	PMC6612190
RN46A-B14 cells	2.5μM	1 hour	To test the effect of ACY-738 on GR nuclear translocation, results showed that ACY-738 significantly inhibited DEX-induced GR translocation.	PMC4297530
RN46A-B14 cells	2.5 μM	4 hours	To evaluate the effect of ACY-738 on α-tubulin acetylation. Results showed that ACY-738 significantly increased the acetylation of α-tubulin but had no significant effect on histone H3K9 acetylation.	PMC3870780
Motor neurons	1 µM	overnight	ACY-738, an HDAC6 inhibitor, was used to rescue axonal transport defects in FUS-ALS patient-derived motor neurons. Results showed that ACY-738 treatment significantly increased the number of moving mitochondria and ER vesicles in motor neurons, restoring axonal transport function.	PMC5636840
Mec2 cells	1 μM	24 hours	ACY738 treatment significantly delayed growth kinetics, reduced cell-cycle progression, and arrested cells in G1 phase, increasing apoptosis.	PMC6234358
OSU-CLL cells	1 μM	24 hours	ACY738 treatment significantly delayed growth kinetics, reduced cell-cycle progression, and arrested cells in G1 phase, increasing apoptosis.	PMC6234358
B cells and T cells	4 μM	24 hours	ACY-738 treatment significantly decreased CO2 production from glucose oxidation in B cells and reduced CO2 production from fatty acid oxidation in both T cells and B cells.	PMC6823248
HCT-116 cells	800 nM		ACY-738 induces tubulin acetylation (a marker of HDAC6 inhibition) at 800nM, whereas histone acetylation (a marker of Class 1 HDAC inhibition) at that concentration is minimal.	PMC6823248
Em-TCL1 B cells	0.5μM	24 hours	To assess the effect of HDAC6 inhibition on antigen presentation by CLL B cells, results showed that ACY738 pre-treatment dose-dependently enhanced T-cell activation.	PMC7719839
CLL patient B cells	0.5μM	24 hours	To assess the effect of HDAC6 inhibition on surface markers of CLL patient B cells, results showed increased expression of MHCII and MHCI, and decreased expression of PD-L1.	PMC7719839
OSU-CLL cells	0.5μM	24 hours	To evaluate the effect of HDAC6 inhibition on CLL B cell engagement with T cells, results showed increased expression of MHCI, MHCII, and CD86, and decreased expression of PD-L1 and 41BB-L.	PMC7719839
Mouse neuroblastoma (N2a) cells	1 μM	overnight	To assess the effect of ACY-738 on α-tubulin acetylation, results showed that ACY-738 significantly enhanced the acetylation of α-tubulin without affecting histone acetylation.	PMC5398982
Mouse mesangial cells (MES 13)	0.5, 1 or 5 nM	2 hours pretreatment followed by 24 hours stimulation	ACY-738 treatment increased Hsp90 acetylation, decreased iNOS protein, and reduced NF-κB nuclear translocation.	PMC4666739
Mouse mesangial cells (MES 13)	1, 2, 5, 10 or 100 nM	24 hours	ACY-738 at 5 nM significantly increased α-tubulin acetylation with little to no effect on histone H3 acetylation.	PMC4666739
Dorsal root ganglion (DRG) neurons	2.5 μM	overnight	To evaluate the ability of ACY-738 to restore mitochondrial axonal transport defects, results showed that ACY-738 significantly increased mitochondrial motility and total number.	PMC5398982

Mice	Chronic social defeat stress model	Intraperitoneal injection	5 mg/kg	Once daily for 20 days	To test the resilience-promoting effect of ACY-738 in social defeat stress, results showed that ACY-738-treated mice maintained higher interaction ratios, indicating enhanced resilience to stress.	PMC4297530
Mice	NIH Swiss mice and HDAC6 KO mice on C57BL/6J background	Intraperitoneal injection	5 mg/kg and 50 mg/kg	Single or repeated administration (24 h, 4 h, and 30 min before killing)	To evaluate the effect of ACY-738 on α-tubulin acetylation in the brain and its antidepressant-like behavioral effects. Results showed that ACY-738 significantly increased α-tubulin acetylation in the brain and exhibited antidepressant-like effects in the tail suspension test and social defeat paradigm. These effects were fully abrogated in mice with a neural-specific loss of function of HDAC6.	PMC3870780
Mice	EuTCL1 transgenic mouse model	Oral	25 mg/kg/day	Once daily for 3 months	ACY738 treatment significantly prolonged overall survival, reduced tumor burden and splenomegaly, decreased proliferation of malignant B cells, and increased sensitivity to apoptosis.	PMC6234358
NZB/W F1 mice	Systemic lupus erythematosus model	Dietary administration	200 mg/kg	Daily administration for 4 weeks	ACY-738 treatment significantly reduced manifestations of lupus nephritis in NZB/W mice, decreased IgG and C3 deposition in glomeruli, and reduced plasma cell and germinal center formation in the spleen.	PMC6823248
Mice	TgFUS+/+ mouse model	Oral	100 mg/kg	Daily administration starting at symptom onset (P30)	ACY-738 treatment significantly extended the lifespan of TgFUS+/+ mice, improved motor performance, and reduced weight loss	PMC6612190
Mice	Em-TCL1 adoptive transfer model	Oral	25mg/kg/day	Once daily for 2 weeks	To evaluate the effect of HDAC6 inhibition on CLL progression, results showed that ACY738 delayed CLL progression, reduced PD-L1 expression, and lowered IL-10 levels.	PMC7719839
Mice	Mutant HSPB1-induced CMT2 mouse model	Intraperitoneal injection	3 mg/kg	Once daily for 21 days	To assess the ability of ACY-738 to reverse motor and sensory deficits, results showed that ACY-738 significantly improved action potential amplitudes in motor and sensory nerves and increased reinnervation of neuromuscular junctions.	PMC5398982
Mice	Amyloid precursor protein/presenilin 1 (APP/PS1) mouse model	Oral	100 mg/kg	Daily for 21 days or 90 days	To evaluate the effects of ACY-738 on axonal transport, behavior, and pathology. Results showed that ACY-738 treatment significantly improved axonal transport rates, recovered short-term learning and memory deficits, reduced hyperactivity, and modified tau and tubulin.	PMC5975056
Mice	Transgenic FUS mice (FUS+/+) expressing wild-type human FUS under the control of the mouse prion promoter (PrP)	Oral	100 mg/kg	Daily administration starting at symptom onset (30 days) until 60 days	ACY-738 treatment restored histone acetylation, slowed down disease progression and significantly expanded the lifespan of transgenic FUS mice. Additionally, ACY-738 restored metabolic alterations in the spinal cord, specifically targeting glycerophospholipid metabolism and reducing cholesteryl esters accumulation.	PMC8541517

{[proInfo.proName]}

CAS No.: 1375465-91-0

{[proInfo.proName]}

CAS No.: 1375465-91-0

Alternative Products

Product Details of ACY-738

Safety of ACY-738

Related Pathways of ACY-738

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	3.70mL 0.74mL 0.37mL	18.50mL 3.70mL 1.85mL	37.00mL 7.40mL 3.70mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed