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Chemical Structure| 957230-65-8 Chemical Structure| 957230-65-8

Structure of Afegostat D-Tartrate
CAS No.: 957230-65-8

Chemical Structure| 957230-65-8

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Afegostat, aslo known as Isofagomine, and AT2101, was an experimental drug for the treatment of certain forms of Gaucher's disease. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone. FG inhibits GCase with K(i) ~30 nM for wild-type and mutant enzymes (N370S and V394L). Administration of IFG (30 mg/kg/day) to the mice homozygous for GCase mutations (V394L, D409H, or D409V) led to increased GCase activity in visceral tissues and brain extracts.

Synonyms: D-Isofagomine D-Tartrate; Isofagomine D-Tartrate; Isofagomine (D-tartrate)

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Product Details of Afegostat D-Tartrate

CAS No. :957230-65-8
Formula : C10H19NO9
M.W : 297.26
SMILES Code : O[C@@H]1CNC[C@H](CO)[C@H]1O.O=C(O)[C@@H](O)[C@H](O)C(O)=O
Synonyms :
D-Isofagomine D-Tartrate; Isofagomine D-Tartrate; Isofagomine (D-tartrate)

Safety of Afegostat D-Tartrate

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Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.36mL

0.67mL

0.34mL

16.82mL

3.36mL

1.68mL

33.64mL

6.73mL

3.36mL

 

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