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Chemical Structure| 6326-06-3 Chemical Structure| 6326-06-3

Structure of AH-7614
CAS No.: 6326-06-3

Chemical Structure| 6326-06-3

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AH 7614 is a selective free fatty acid receptor 4 (FFA4/GPR120) antagonist with pIC50 of 7.1 for human FFA4.

Synonyms: NSC 31171; N-xanthen-9-yl-p-Toluenesulfonamide

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Product Details of AH-7614

CAS No. :6326-06-3
Formula : C20H17NO3S
M.W : 351.42
SMILES Code : CC(C=C4)=CC=C4S(NC2C3=C(C=CC=C3)OC1=CC=CC=C12)(=O)=O
Synonyms :
NSC 31171; N-xanthen-9-yl-p-Toluenesulfonamide
MDL No. :MFCD00379273

Safety of AH-7614

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of AH-7614

GPCR

Isoform Comparison

Biological Activity

Description
AH-7614 demonstrates potent and selective antagonism against FFA4 (GPR120), with pIC50 values of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. It exhibits selectivity for FFA4 over FFA1 (pIC50<4.6). AH-7614 effectively inhibits the actions of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist[1].[2].

In Vitro:

Cell Line
Concentration Treated Time Description References
Murine C3H10T1/2 mesenchymal stem cells 10 μM 5 days AH-7614 inhibited FFA4-mediated adipocyte differentiation PMC5438128
Cardiomyocytes 10 µM 24 h To investigate the effect of AH-7614 on EPA's rescue of OAPA-induced decline in Cav1.2 and CREB mRNA expression via FFAR4 pathway. Results showed AH-7614 blocked EPA's rescue effect. PMC11276759
Pancreatic acinar AR42J cells 10 μM 2 h AH-7614 suppressed the inhibitory effect of DHA on cerulein-induced zymogen activation PMC7092610

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Wistar rats Myocardial infarction model Ex vivo heart perfusion 7 µmol/L 1 hour To evaluate the effect of AH-7614 on GPR120-mediated ROS and Cx43 phosphorylation. AH-7614 reversed the inhibitory effect of IPE on ROS and suppressed the increase in Cx43 phosphorylation. PMC7417730

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.85mL

0.57mL

0.28mL

14.23mL

2.85mL

1.42mL

28.46mL

5.69mL

2.85mL

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