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Structure of Alendronic acid
CAS No.: 66376-36-1
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Alendronate is a bisphosphonate drug used for osteoporosis, osteogenesis imperfecta, and several other bone diseases.
Synonyms: Alendronate
4.5
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 66376-36-1 |
Formula : | C4H13NO7P2 |
M.W : | 249.10 |
SMILES Code : | OC(P(O)(O)=O)(P(O)(O)=O)CCCN |
Synonyms : |
Alendronate
|
MDL No. : | MFCD00868112 |
GHS Pictogram: |
![]() |
Signal Word: | Danger |
Hazard Statements: | H314 |
Precautionary Statements: | P280-P305+P351+P338-P310 |
Class: | 8 |
UN#: | 1759 |
Packing Group: | Ⅱ |
In Vitro:
Concentration | Treated Time | Description | References |
Human peripheral blood mononuclear cells | 10^-10 M | 15 days | To evaluate the inhibitory effect of ALN on osteoclastogenesis, 10^-10 M ALN promoted cell proliferation and osteoclast-like cell formation. | PMC8035832 |
Human peripheral blood mononuclear cells | 10^-8 M | 15 days | To evaluate the inhibitory effect of ALN on osteoclastogenesis, 10^-8 M ALN promoted cell proliferation and osteoclast-like cell formation. | PMC8035832 |
Human peripheral blood mononuclear cells | 10^-6 M | 15 days | To evaluate the inhibitory effect of ALN on osteoclastogenesis, 10^-6 M ALN was cytotoxic and inhibited cell proliferation. | PMC8035832 |
Rat peripheral blood mononuclear cells | 10^-10 M | 15 days | To evaluate the inhibitory effect of ALN on osteoclastogenesis, 10^-10 M ALN promoted cell proliferation and osteoclast-like cell formation. | PMC8035832 |
Rat peripheral blood mononuclear cells | 10^-8 M | 15 days | To evaluate the inhibitory effect of ALN on osteoclastogenesis, 10^-8 M ALN promoted cell proliferation and osteoclast-like cell formation. | PMC8035832 |
Rat peripheral blood mononuclear cells | 10^-6 M | 15 days | To evaluate the inhibitory effect of ALN on osteoclastogenesis, 10^-6 M ALN was cytotoxic and inhibited cell proliferation. | PMC8035832 |
RAW264.7 cells | 0.1 μM, 0.2 μM, 0.4 μM | 5 days | To evaluate the effect of EA on osteoclast differentiation, results showed that EA concentration-dependently inhibited RANKL-induced osteoclastogenesis. | PMC11330075 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Wistar rats | Osteoporosis model (bilateral ovariectomy) | Oral | 3.5 mg/kg | Once a week for 6 weeks | Evaluate the effect of scaffolds with local ALN release on bone defect healing in osteoporotic and control rats, results showed ALN supported peri-implant bone formation, but systemic ALN administration did not show a positive effect. | PMC9901358 |
Wistar rats | Ovariectomy-induced osteoporosis model | Oral | 2.5 mg/kg | Daily administration for 90 days | To evaluate the therapeutic effect of ALN on osteoporosis, results showed that ALN significantly alleviated osteoporosis. | PMC11330075 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00666627 | Post-menopausal Osteoporosis | Phase 2 | Completed | - | United Kingdom ... More >> Academic Unit of Bone Metabolism (Sheffield) Sheffield, South Yorkshire, United Kingdom, S5 7AU Less << |
NCT00061256 | HIV Infections | Phase 2 | Completed | - | - |
NCT00051558 | Osteoporosis | Phase 3 | Completed | - | United States, California ... More >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Loma Linda, California, United States For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Palo Alto, California, United States United States, Colorado For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Aurora, Colorado, United States United States, North Dakota For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Fargo, North Dakota, United States For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Jamestown, North Dakota, United States United States, Wisconsin For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Milwaukee, Wisconsin, United States Austria For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Graz, Austria For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Vienna, Austria Belgium For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Brussels, Belgium For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Gent, Belgium For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Leuven, Belgium Denmark For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Aarhus, Denmark Norway For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Oslo, Norway Puerto Rico For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Carolina, Puerto Rico For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Ponce, Puerto Rico Less << |
NCT00503113 | Post-Menopausal Osteoporosis | Phase 4 | Completed | - | - |
NCT00398606 | Osteoporosis, Postmenopausal | Phase 3 | Completed | - | - |
NCT00503113 | - | Completed | - | - | |
NCT02516111 | Chronic Periodontitis | Phase 2 Phase 3 | Completed | - | - |
NCT00000400 | Osteoporosis | Phase 2 | Completed | - | United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Less << |
NCT00130403 | Osteoporosis, Postmenopausal | Phase 4 | Completed | - | United States, New Jersey ... More >> sanofi-aventis, US Bridgewater, New Jersey, United States, 08807 Australia, New South Wales sanofi-aventis, Australia Cove, New South Wales, Australia Belgium sanofi-aventis, Belgium Diegem, Belgium Canada, Quebec sanofi-aventis, Canada Laval, Quebec, Canada France sanofi-aventis, France Paris, France Netherlands sanofi-aventis, Netherlands Gouda, Netherlands United Kingdom sanofi-aventi, UK Guildford, Surrey, United Kingdom Less << |
NCT00000430 | Osteopenia Os... More >>teoporosis Less << | Phase 3 | Terminated | - | United States, Nebraska ... More >> Creighton University Osteoporosis Research Center Omaha, Nebraska, United States, 68131 Less << |
NCT01648686 | Alveolar Bone Healing After De... More >>ntal Extraction Less << | Not Applicable | Completed | - | France ... More >> Hotel-Dieu Hospital Nantes, France, 44042 Less << |
NCT03396315 | IOP Osteoporo... More >>sis Less << | Phase 2 | Recruiting | January 1, 2024 | United States, Nebraska ... More >> Creighton University Not yet recruiting Omaha, Nebraska, United States, 68131 Contact 402-280-4470 Principal Investigator: Robert Recker, MD Sub-Investigator: Joan Lappe, MD United States, New York Columbia University Medical Center Recruiting New York, New York, United States, 10032 Contact: Mariana Bucovsky, BA 212-305-7225 Principal Investigator: Elizabeth Shane, MD Sub-Investigator: Adi Cohen, MD Less << |
NCT00138983 | Rheumatoid Arthritis ... More >> Polymyalgia Rheumatica Giant Cell Arteritis Polymyositis Wegener’s Granulomatosis Less << | Phase 3 | Completed | - | Netherlands ... More >> UMC Utrecht Utrecht, Netherlands, 3584 CX Less << |
NCT00051558 | - | Completed | - | - | |
NCT00019695 | Stage IV Prostate Cancer ... More >> Bone Metastases Adenocarcinoma of the Prostate Recurrent Prostate Cancer Less << | Phase 2 | Terminated | - | United States, Maryland ... More >> Medicine Branch Bethesda, Maryland, United States, 20892 Less << |
NCT02609061 | Furcation Defects | Phase 2 Phase 3 | Completed | - | India ... More >> Government Dental College and Research Institute Bangalore, Karnataka, India, 560002 Less << |
NCT01020253 | Bone Density ... More >>Arthroplasty, Replacement, Hip Less << | Not Applicable | Unknown | - | Japan ... More >> Department of orthopaedic surgery, Yokohama City University Yokohama, Kanagawa, Japan Less << |
NCT00641771 | Osteoporosis | Phase 1 | Completed | - | - |
NCT00221312 | - | Completed | - | United States, California ... More >> University of California, San Francisco San Francisco, California, United States, 94143 Less << | |
NCT01631214 | Postmenopausal Women With Oste... More >>oporosis Less << | Phase 3 | Completed | - | - |
NCT01588509 | Osteoporosis | Phase 1 | Completed | - | United States, Arizona ... More >> Research Site Tucson, Arizona, United States, 85711 United States, California Research Site Walnut Creek, California, United States, 94598 United States, Georgia Research Site Gainesville, Georgia, United States, 30501 United States, Hawaii Research Site Honolulu, Hawaii, United States, 96813 United States, Maryland Research Site Bethesda, Maryland, United States, 20817 United States, New Mexico Research Site Albuquerque, New Mexico, United States, 87106 United States, New York Research Site West Haverstraw, New York, United States, 10993 United States, Pennsylvania Research Site Wyomissing, Pennsylvania, United States, 19610 United States, Washington Research Site Seattle, Washington, United States, 98144 Less << |
NCT01128257 | - | Completed | - | Germany ... More >> Marburg, Germany, 35043 Less << | |
NCT00400530 | Osteoporosis | Phase 3 | Completed | - | - |
NCT00001720 | Osteoporosis | Phase 2 | Completed | - | United States, Maryland ... More >> National Institute of Child Health and Human Development (NICHD) Bethesda, Maryland, United States, 20892 Less << |
NCT01631214 | - | Completed | - | - | |
NCT01968850 | HIV | Phase 2 | Completed | - | Canada, Ontario ... More >> St. Michael's Hospital Toronto, Ontario, Canada, M5B 1W8 Toronto General Hospital Toronto, Ontario, Canada, M5G 2N2 Less << |
NCT00001728 | Polyostotic Fibrous Dysplasia | Phase 2 | Completed | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT01350934 | Osteoporosis, Postmenopausal | Phase 4 | Completed | - | - |
NCT00005005 | Osteoporosis | Phase 2 | Completed | - | United States, Maine ... More >> Maine Center for Osteoporosis Bangor, Maine, United States, 04401 United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States, 55415 United States, New York Columbia University New York, New York, United States, 10032 United States, Pennsylvania University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15213 Less << |
NCT01350934 | - | Completed | - | - | |
NCT02455869 | Chronic Periodontitis | Phase 2 Phase 3 | Completed | - | - |
NCT00346190 | Osteoporosis | Phase 3 | Unknown | April 2007 | Canada, Quebec ... More >> Mcgill University Health center Recruiting Montreal, Quebec, Canada, H3A 1A1 Contact: Richard Kremer, MD PhD 514-934-1934 ext 32857 Principal Investigator: Richard Kremer, MD PhD FRCP(c) Less << |
NCT00120757 | Osteoporosis ... More >>HIV Infections Less << | Phase 3 | Completed | - | France ... More >> Service de Medecine Interne hopital Avicenne Bobigny, France, 93009 cedex Service de Rhumatologie hopital Pitie-Salpetriere Paris, France, 75013 Hôpital Necker service des Maladies Infectieuses Paris, France, 75015 Less << |
NCT00518531 | Osteoporosis | Phase 3 | Completed | - | - |
NCT00330460 | Osteoporosis ... More >>Osteopenia Less << | Phase 3 | Completed | - | - |
NCT00330460 | - | Completed | - | - | |
NCT00293813 | Postmenopausal Osteoporosis | Phase 2 | Completed | - | - |
NCT00293813 | - | Completed | - | - | |
NCT00404820 | Osteoporosis | Phase 3 | Completed | - | Germany ... More >> For site information contact Novartis Pharmaceuticals Multiple Cities, Germany Less << |
NCT00518531 | - | Completed | - | - | |
NCT00404820 | - | Completed | - | - | |
NCT00092014 | Postmenopausal Osteoporosis | Phase 3 | Completed | - | - |
NCT03623633 | Osteoporosis, Postmenopausal ... More >> Osteoporosis Less << | Phase 4 | Not yet recruiting | December 1, 2021 | - |
NCT00377819 | - | Completed | - | - | |
NCT00377819 | Postmenopausal Osteoporosis | Phase 3 | Completed | - | - |
NCT00122356 | Breast Cancer | Phase 3 | Completed | - | Australia, New South Wales ... More >> Sydney South West Area Health Service Sydney, New South Wales, Australia, 2050 Tweed Hospital Tweed Heads, New South Wales, Australia, 2485 Australia, Victoria Box Hill Hospital Box Hill, Victoria, Australia, 3128 Maroondah Breast Clinic East Ringwood, Victoria, Australia, 3135 St Vincent's Health Fitzroy, Victoria, Australia, 3065 Barwon Health Geelong, Victoria, Australia, 3220 St John of God Healthcare Geelong, Victoria, Australia, 3220 South West Healthcare Warrnambool, Victoria, Australia, 3280 Less << |
NCT00265252 | Non-Traumatic Osteonecrosis | Phase 4 | Unknown | June 2008 | Taiwan ... More >> Kaohsiung Medical University Chung-Ho Memorial Hospital Kaohsiung, Taiwan, 807 Less << |
NCT01770106 | Rheumatoid Arthritis | Phase 4 | Completed | - | Hong Kong ... More >> Prince of Wales Hospital Shatin, N.t., Hong Kong Less << |
NCT01460654 | Hypogonadism ... More >>Osteopenia Osteoporosis Less << | Phase 2 | Suspended | June 2019 | United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Less << |
NCT02518152 | Chronic Periodontitis | Phase 2 Phase 3 | Completed | - | India ... More >> Government Dental College and Research Institute Bangalore, Karnataka, India, 560002 Less << |
NCT01065779 | - | Completed | - | - | |
NCT00299572 | Peritoneal Dialysis | Phase 4 | Unknown | - | Taiwan ... More >> Far Eastern Memorial Hospital Not yet recruiting Taipei, Taiwan, 220 Less << |
NCT00391404 | Osteoporosis | Phase 3 | Unknown | October 2008 | Hong Kong ... More >> Prince of Wales Hospital, Shatin, N.T. Recruiting Hong Kong, Hong Kong Sub-Investigator: Patrick MP Yuen, MD, FRCPC Sub-Investigator: Chi Kong Li, MBBS, MD Sub-Investigator: Christopher WK Lam, PhD Sub-Investigator: Vincent Lee, MBChB Less << |
NCT00277251 | Glucocorticoid-Associated Oste... More >>openia and Osteoporosis Less << | Phase 2 Phase 3 | Completed | - | - |
NCT00729651 | Osteoporosis Postmenopausal | Phase 4 | Completed | - | - |
NCT01065779 | - | Completed | - | - | |
NCT00729651 | - | Completed | - | - | |
NCT00983996 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... More >> PRACS Insitute Ltd. Fargo, North Dakota, United States, 58104 Less << |
NCT00778154 | - | Completed | - | United States, California ... More >> Warner Chilcott Research Facility Palm Desert, California, United States, 92269 United States, Colorado Warner Chilcott Research Facility Lakewood, Colorado, United States, 80227 United States, Georgia Warner Chilcott Research Facility Decatur, Georgia, United States, 30033 Warner Chilcott Research Facility Gainesville, Georgia, United States, 30501 United States, Nebraska Warner Chilcott Research Facility Omaha, Nebraska, United States, 68131 United States, Ohio Warner Chilcott Research Facility Cincinnati, Ohio, United States, 45219 United States, Pennsylvania Warner Chilcott Research Facility Wyomissing, Pennsylvania, United States, 19610 Canada, Quebec Warner Chilcott Research Facility Montreal, Quebec, Canada, H2X 1P1 Less << | |
NCT02416271 | Osteoporosis | Phase 4 | Completed | - | - |
NCT01552122 | Osteoporosis ... More >>Postmenopausal Osteoporosis Less << | Phase 3 | Withdrawn | February 2015 | - |
NCT01012934 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... More >> PRACS Insitute Ltd. Fargo, North Dakota, United States, 58104 Less << |
NCT00005006 | Osteoporosis | Phase 2 | Completed | - | United States, New York ... More >> Helen Hayes Hospital, Clinical Research Center West Haverstraw, New York, United States, 10993 Less << |
NCT00327990 | Osteoporosis | Phase 4 | Completed | - | Netherlands ... More >> GSK Investigational Site Bennebroek, Netherlands, 2121 BB GSK Investigational Site Breda, Netherlands, 4834 AD GSK Investigational Site Damwoude, Netherlands, 9104 GJ GSK Investigational Site Den Haag, Netherlands, 2544 KM GSK Investigational Site Den Haag, Netherlands, 2582 LJ GSK Investigational Site Den Haag, Netherlands, 2584 HV GSK Investigational Site Driebergen-rijsenburg, Netherlands, 3972 WG GSK Investigational Site Easterein, Netherlands, 8734 CG GSK Investigational Site Eersel, Netherlands, 5521 CD GSK Investigational Site Eindhoven, Netherlands, 5613 BE GSK Investigational Site Enschede, Netherlands, 7544 NZ GSK Investigational Site Etten-leur, Netherlands, 4872 LA GSK Investigational Site Geleen, Netherlands, 6163 GC GSK Investigational Site Groesbeek, Netherlands, 6561 CM GSK Investigational Site Heerlen, Netherlands, 6417 BR GSK Investigational Site Hengelo, Netherlands, 7255 AM GSK Investigational Site Hoogvliet, Netherlands, 3192 JN GSK Investigational Site Hoogwoud, Netherlands, 1718 BG GSK Investigational Site Hulst, Netherlands, 4561 CJ GSK Investigational Site Landgraaf, Netherlands, 6373 JS GSK Investigational Site Losser, Netherlands, 7581 BV GSK Investigational Site Midwoud, Netherlands, 1679 GJ GSK Investigational Site Nijverdal, Netherlands, 7442 LS GSK Investigational Site Nunspeet, Netherlands, 8071 LX GSK Investigational Site Oldebroek, Netherlands, 8096 AV GSK Investigational Site Oudenbosch, Netherlands, 4731 MA GSK Investigational Site Poortvliet, Netherlands, 4693 BT GSK Investigational Site Prinsenbeek, Netherlands, 4841 RR GSK Investigational Site Raalte, Netherlands, 8101 ZW GSK Investigational Site Ridderkerk, Netherlands, 2985 VG GSK Investigational Site Rotterdam, Netherlands, 3082 DC GSK Investigational Site Spijkenisse, Netherlands, 3207 NB GSK Investigational Site Tilburg, Netherlands, 5038 DE GSK Investigational Site Voerendaal, Netherlands, 6367 ED GSK Investigational Site Wassenaar, Netherlands, 2241 KE GSK Investigational Site Wildervank, Netherlands, 9648 BE GSK Investigational Site Woerden, Netherlands, 3443 GG GSK Investigational Site Zaandam, Netherlands, 1504 JA Less << |
NCT00580047 | Renal Insufficiency | Not Applicable | Completed | - | United States, Nebraska ... More >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Less << |
NCT00739466 | Coronary Artery Stenosis | Phase 2 | Completed | - | Israel ... More >> Hillel Yaffe Medical Center Hadera, Israel, 38100 Bnei Zion Medical Center Haifa, Israel, 31048 Rambam Health Care Campus Haifa, Israel, 31096 Lady Davis Carmel Medical Center Haifa, Israel, 34362 Shaare Zedek Medical Center Jerusalem, Israel, 91031 Meir Medical Center Kfar Saba, Israel, 44281 Western Galilee Hospital, Nahariya Nahariya, Israel, 22100 Rabin Medical Center Petah Tikva, Israel, 49100 The Baruch Padeh Medical Center, Poriya Poriya, Israel, 15218 Sheba Medical Center, Tel Hashomer Ramat Gan, Israel, 52521 Kaplan Medical Center Rehovot, Israel, 76100 The Tel Aviv Sourasky Medical Center Tel Aviv, Israel, 64239 Less << |
NCT03204097 | Chronic Periodontitis | Phase 2 Phase 3 | Completed | - | - |
NCT03197623 | Osteopenia Os... More >>teoporosis Osteonecrosis Less << | Phase 1 | Recruiting | June 2020 | United States, California ... More >> West Coast Clinical Trials (WCCT) Recruiting Cypress, California, United States, 92626 Contact: Kacie Hale, BS 714-252-0700 kacie.hale@wcct.com Principal Investigator: Bonnie Bock, MD Diablo Clinical Research Recruiting Walnut Creek, California, United States, 94598 Contact: Lana Norman 925-930-7267 lnorman@Diabloclinical.com Contact: Ava Paulazzo (925) 930-7267 apaulazzo@Diabloclinical.com Principal Investigator: Mark Christiansen, MD United States, Pennsylvania Altoona Center for Clinical Research Recruiting Duncansville, Pennsylvania, United States, 16635 Contact: Lisa Claycomb 814-696-7053 altoonaresearch@gmail.com Principal Investigator: Alan Kivitz, MD United States, Texas Metroplex Clinical Research Center Recruiting Dallas, Texas, United States, 75231 Contact: Michael Johnson 214-879-6737 mjohnson@mcrcdallas.com Principal Investigator: Roy Fleischmann, MD Less << |
NCT00463268 | Osteopenia | Phase 3 | Completed | - | Belgium ... More >> University (UCL) Louvain Hospital in Mont-Godinne Yvoir, Namur, Belgium, 5530 Less << |
NCT00261625 | End-Stage Renal Disease ... More >> Osteoporosis Less << | Phase 4 | Completed | - | - |
NCT01512446 | Osteoporosis | Phase 3 | Terminated(low recruitment rat... More >>e) Less << | - | Germany ... More >> Department of Internal Medicine III, Alfried Krupp Krankenhaus Essen Steele Essen, Germany, 45276 Less << |
NCT00580047 | - | Completed | - | - | |
NCT02598440 | Postmenopausal Osteoporosis | Phase 4 | Completed | - | - |
NCT00806416 | Osteoporosis | Phase 1 | Completed | - | - |
NCT00236002 | Osteoporosis | Phase 3 | Terminated(Slow accrual than a... More >>nticipated.) Less << | - | - |
NCT00713258 | Back Pain | Phase 4 | Terminated(Slow enrolment) | - | Denmark ... More >> Nycomed Roskilde, Denmark, 4000 Less << |
NCT01889134 | Primary Hyperparathyroidism | Not Applicable | Completed | - | Poland ... More >> Department of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University Wroclaw, Poland, 50-367 Less << |
NCT01437111 | Osteoporosis | Phase 3 | Completed | - | - |
NCT01812551 | Osteoporosis ... More >>Cystic Fibrosis Less << | Phase 3 | Completed | - | Holy See (Vatican City State) ... More >> CRR Fibrosi Cistica, Divisione Gastroenterologia, Ospedale Bambin Gesù Città del Vaticano, Holy See (Vatican City State) Italy CRR Fibrosi Cistica, Unità Operativa di Pediatria, Ospedale Misericordia Grosseto, Italy CRR Fibrosi Cistica, Clinica Pediatrica, Policlinico Universitario di Messina Messina, Italy Istituto Auxologico Italiano IRCCS Milano, Italy, 20145 Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Università degli Studi di Milano Milano, Italy CRR Fibrosi Cistica, Dipartimento Pediatria, Università Federico II Napoli, Italy CRR Fibrosi Cistica Adulti, Azienda Ospedaliera Universitaria San Luigi Gonzaga Orbassano, Italy CRR Fibrosi Cistica, Ospedale dei Bambini, ARNAS Civico Palermo, Italy CRR Fibrosi Cistica, Dipartimento di Pediatria, Policlinico Umberto I Roma, Italy CRR Fibrosi Cistica, Divisione di Pediatria, Istituto Burlo Garofolo Trieste, Italy CRR Fibrosi Cistica, Azienda Ospedalierouniversitaria di Verona Verona, Italy Less << |
NCT00395382 | Vascular Calcification ... More >> Arteriosclerosis Less << | Phase 4 | Completed | - | Australia, Victoria ... More >> Department of Nephrology, Monash Medical Centre Clayton, Victoria, Australia, 3168 Less << |
NCT00010439 | - | Completed | - | - | |
NCT00806416 | - | Completed | - | - | |
NCT00010439 | Osteoporosis | Phase 2 | Completed | - | United States, South Carolina ... More >> Medical University of South Carolina Charleston, South Carolina, United States, 29425 Less << |
NCT00713258 | - | Terminated(Slow enrolment) | - | - | |
NCT00297830 | Heart Transplantation ... More >> Liver Transplantation Bone Resorption Less << | Phase 2 Phase 3 | Completed | - | United States, New York ... More >> Columbia University Medical Center New York, New York, United States, 10032 Less << |
NCT00835406 | - | Completed | - | - | |
NCT01131884 | - | Terminated(Only 1 participant ... More >>enrolled since the beginning of this study) Less << | - | - | |
NCT01437111 | - | Completed | - | - | |
NCT01131884 | Spinal Cord Injury ... More >> Osteoporosis Less << | Not Applicable | Terminated(Only 1 participant ... More >>enrolled since the beginning of this study) Less << | - | United States, New York ... More >> University of Rochester Physical Medicine and Rehabilitation Rochester, New York, United States, 14642 University of Rochester Rochester, New York, United States, 14642 Less << |
NCT00835406 | Healthy | Phase 1 | Completed | - | Canada, Quebec ... More >> Anapharm Inc. Sainte-Foy, Quebec, Canada, GIV2K8 Less << |
NCT02795546 | Intrabony Periodontal Defect | Phase 4 | Completed | - | - |
NCT00803790 | Osteoporosis | Phase 1 | Completed | - | - |
NCT00297830 | - | Completed | - | - | |
NCT02230332 | Asthma | Phase 2 Phase 3 | Completed | - | United States, Arizona ... More >> University of Arizona College of Medicine Tucson, Arizona, United States, 85724 United States, California University of California - San Francisco San Francisco, California, United States, 94143 United States, Colorado National Jewish Health Denver, Colorado, United States, 80206 United States, Illinois Northwestern Memorial Hospital Chicago, Illinois, United States, 60611 University of Illinois at Chicago Chicago, Illinois, United States, 60612 University of Chicago Chicago, Illinois, United States, 60637 United States, Massachusetts Brigham & Women's Hospital Boston, Massachusetts, United States, 02115 United States, Missouri Washington University Saint Louis, Missouri, United States, 63110 United States, North Carolina Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 United States, Wisconsin University of Wisconsin Madison, Wisconsin, United States, 53972 Less << |
NCT02230332 | - | Completed | - | - | |
NCT02944799 | Rheumatoid Arthritis ... More >> Osteoporosis Less << | Phase 2 | Recruiting | July 2021 | Denmark ... More >> Aalborg University Hospital Recruiting Aalborg, Denmark, 9000 Principal Investigator: Salome Kristensen, PhD Aarhus University Hospital Recruiting Aarhus, Denmark, 8000 Sub-Investigator: Anne-Birgitte Blavnsfeldt, MD Hjørring Hospital Not yet recruiting Hjørring, Denmark, 9800 Principal Investigator: Norah Thomsen, MD Odense University Hospital Recruiting Odense, Denmark, 5000 Principal Investigator: Hanne Lindegaard, PhD Silkeborg Regional Hospital Active, not recruiting Silkeborg, Denmark, 8600 Vejle Hospital Active, not recruiting Vejle, Denmark, 7100 Less << |
NCT00577850 | Osteopenia Os... More >>teoporosis Less << | Phase 1 | Completed | - | United States, Florida ... More >> Research Facility Gainesville, Florida, United States United States, Louisiana Research Site New Orleans, Louisiana, United States Less << |
NCT00921557 | HIV Infection | Phase 2 | Completed | - | United States, California ... More >> David Geffen School of Medicine at UCLA NICHD CRS Los Angeles, California, United States, 90095-1752 United States, Florida Pediatric Perinatal HIV Clinical Trials Unit CRS Miami, Florida, United States, 33136 USF - Tampa NICHD CRS Tampa, Florida, United States, 33606 United States, Illinois Lurie Children's Hospital of Chicago (LCH) CRS Chicago, Illinois, United States, 60614-3393 United States, Maryland Johns Hopkins Univ. Baltimore NICHD CRS Baltimore, Maryland, United States, 21287 United States, Massachusetts WNE Maternal Pediatric Adolescent AIDS CRS Worcester, Massachusetts, United States, 01605 United States, Tennessee St. Jude Children's Research Hospital CRS Memphis, Tennessee, United States, 38105 Brazil SOM Federal University Minas Gerais Brazil NICHD CRS Belo Horizonte, Minas Gerais, Brazil, 30130-100 Univ. of Sao Paulo Brazil NICHD CRS Sao Paulo, Brazil, 14049-900 Puerto Rico San Juan City Hosp. PR NICHD CRS San Juan, Puerto Rico, 00936 Less << |
NCT00803790 | - | Completed | - | - | |
NCT02303873 | Osteogenesis Imperfecta | Phase 4 | Completed | - | - |
NCT00259857 | Osteoporosis | Phase 2 | Completed | - | United States, South Carolina ... More >> Medical University of South Carolina Charleston, South Carolina, United States, 29425 Less << |
NCT02057263 | Hepatitis B | Phase 1 | Completed | - | United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Less << |
NCT00157690 | Cystic Fibrosis ... More >> Osteoporosis Bone Diseases, Metabolic Less << | Phase 4 | Completed | - | Canada, Alberta ... More >> Dr. Harvey Rabin - Health Sciences Centre Calgary, Alberta, Canada, T2N 4N1 Canada, Ontario McMaster University Hamilton, Ontario, Canada London Health Sciences Centre London, Ontario, Canada, N6A 4G5 Canada, Quebec Centre de Recherche - CHUM Montreal, Quebec, Canada, H2W 1T7 Montreal Chest Institute Montreal, Quebec, Canada, H2X 2P4 CHUL Hospital Sainte-Foy, Quebec, Canada, G1V 4G2 Less << |
NCT00936260 | Osteoporosis | Not Applicable | Completed | - | Spain ... More >> University San Carlos Hospital Madrid, Spain, 28040 Less << |
NCT00921557 | - | Completed | - | - | |
NCT02195895 | Spinal Cord Injury ... More >> Bone Loss Osteoporosis Less << | Phase 2 | Completed | - | United States, Illinois ... More >> Northwestern University Feinberg School of Medicine Chicago, Illinois, United States, 60611 Less << |
NCT00504166 | Osteopenia Os... More >>teoporosis Less << | Phase 4 | Completed | - | United States, California ... More >> University of California Department of Radiology San Francisco, California, United States, 94107 Less << |
NCT00504166 | - | Completed | - | - | |
NCT00460057 | Osteoporosis | Phase 4 | Completed | - | - |
NCT02322099 | Bone Demineralization | Phase 4 | Unknown | October 2018 | Ireland ... More >> Mater Misericordiae University Hospital Recruiting Dublin, Ireland, 7 Contact: Tara McGinty, MB, BCh, BAO tara.mcginty@ucd.ie Contact: Patrick WG Mallon, MB BCh, PhD, FRCPI paddy.mallon@ucd.ie Sub-Investigator: John Lambert, MD, PhD Sub-Investigator: Gerard Sheehan, MB BCh BAO, FRCPI Beaumont Hospital Recruiting Dublin, Ireland, 9 Contact: Samuel McConkey, MB BCh, MD,MRCPI smcconkey@rcsi.ie Contact: Nora McNally, MD Less << |
NCT03005678 | Osteoporosis | Phase 4 | Recruiting | February 2020 | China ... More >> Department of Medicine, Tuen Mun Hospital Recruiting Hong Kong, China, 000 Contact: Chi Chiu Mok, MD, FRCP (852) 2468 5386 ccmok2006@gmail.com Principal Investigator: Chi Chiu Mok, MD, FRCP Less << |
NCT00259857 | - | Completed | - | - | |
NCT01104987 | - | Completed | - | Sweden ... More >> Department of Rheumatology, Sahlgrenska University Hospital Gothenburg, Sweden, S-413 45 Less << | |
NCT02470611 | Periodontitis ... More >> Bone Resorption Less << | Phase 4 | Completed | - | Brazil ... More >> Dental clinic of pontifical catholic university Belo Horizonte, Minas Gerais, Brazil Less << |
NCT02195895 | - | Completed | - | - | |
NCT02168543 | Chronic Periodontitis | Phase 2 | Completed | - | - |
NCT02781805 | Breast Neoplasms | Phase 1 | Recruiting | August 1, 2019 | United States, Wisconsin ... More >> University of Wisconsin Carbone Cancer Center Recruiting Madison, Wisconsin, United States, 53705 Contact: Cancer Connect 800-622-8922 cancerconnect@uwcarbone.wisc.edu Principal Investigator: Lee Wilke Less << |
NCT00920075 | - | Completed | - | United States, South Carolina ... More >> Medical University of South Carolina Charleston, South Carolina, United States, 29425 Less << | |
NCT03435094 | - | Not yet recruiting | August 1, 2019 | Switzerland ... More >> Endokrinologische Praxis & Labor Not yet recruiting Basel, BS, Switzerland, 4055 Contact: Christian Meier, Prof Hôpital Universitaire de Genève, Service des maladies osseuses Not yet recruiting Genève, GE, Switzerland, 1211 Contact: Serge Ferrari, Prof Less << | |
NCT01133496 | Healthy | Phase 1 | Completed | - | India ... More >> GVK Biosciences Pvt. Ltd., Hyderabad, Andhra Pradesh, India, 500038 Less << |
NCT02461667 | Chronic Periodontitis | Phase 2 Phase 3 | Completed | - | - |
NCT02371252 | Osteoporosis | Phase 4 | Unknown | October 2017 | Thailand ... More >> Siriraj Hospital Recruiting Bangkok Noi, Bangkok, Thailand, 10700 Contact: Aasis Unnanuntana, MD +66-2419-7968 uaasis@gmail.com Contact: Atthakorn Jarusriwanna, MD +66-2419-7968 wonton2ton@hotmail.com Less << |
NCT03542695 | Breast Carcinoma ... More >> Calcification Less << | Early Phase 1 | Not yet recruiting | December 7, 2020 | United States, California ... More >> City of Hope Medical Center Not yet recruiting Duarte, California, United States, 91010 Contact: Veronica C. Jones, MD 626-471-7100 vjones@coh.org Principal Investigator: Veronica C. Jones, MD Less << |
NCT00359385 | Hyperparathyroidism | Phase 4 | Withdrawn(incomplete enrollmen... More >>t) Less << | - | United States, New York ... More >> CUMC New York, New York, United States, 10032 Less << |
NCT03051620 | - | Active, not recruiting | July 1, 2019 | Denmark ... More >> Department of Endocrinology and Internal Medicine, Aarhus University Hospital Aarhus, Denmark, 8000 Less << | |
NCT00920075 | - | Completed | - | - |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
4.01mL 0.80mL 0.40mL |
20.07mL 4.01mL 2.01mL |
40.14mL 8.03mL 4.01mL |
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Dissolving Methods |
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
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