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Chemical Structure| 473-08-5 Chemical Structure| 473-08-5

Structure of alpha-Cyperone
CAS No.: 473-08-5

Chemical Structure| 473-08-5

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α-Cyperone, a natural product isolated and purified from the hizomes of Cyperus rotundus L., is associated with the down-regulation of COX-2,IL-6,Nck-2,Cdc42 and Rac1, resulting in reduction of inflammation.

Synonyms: (+)-α-Cyperone; α-Cyperone

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Product Details of alpha-Cyperone

CAS No. :473-08-5
Formula : C15H22O
M.W : 218.33
SMILES Code : CC(C(CC[C@@](C)1CC2)=O)=C1C[C@@H]2C(C)=C
Synonyms :
(+)-α-Cyperone; α-Cyperone
MDL No. :MFCD09839027
InChI Key :KUFXJZXMWHNCEH-DOMZBBRYSA-N
Pubchem ID :6452086

Safety of alpha-Cyperone

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of alpha-Cyperone

pyroptosis

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.58mL

0.92mL

0.46mL

22.90mL

4.58mL

2.29mL

45.80mL

9.16mL

4.58mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

[1]Azimi A, Ghaffari SM, et al. α-Cyperone of Cyperus rotundus is an effective candidate for reduction of inflammation by destabilization of microtubule fibers in brain. J Ethnopharmacol. 2016 Dec 24;194:219-227.

[2]Jung SH, Kim SJ, et al. α-Cyperone, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced COX-2 expression and PGE2 production through the negative regulation of NFκB signalling in RAW 264.7 cells. J Ethnopharmacol. 2013 May 2;147(1):208-14.

[3]Huang B, Liu J, Fu S, Zhang Y, Li Y, He D, Ran X, Yan X, Du J, Meng T, Gao X, Liu D. α-Cyperone Attenuates H2O2-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2. Front Pharmacol. 2020 Apr 8;11:281

[4]Jung SH, Kim SJ, Jun BG, Lee KT, Hong SP, Oh MS, Jang DS, Choi JH. α-Cyperone, isolated from the rhizomes of Cyperus rotundus, inh+ibits LPS-induced COX-2 expression and PGE2 production through the negative regulation of NFκB signalling in RAW 264.7 cells. J Ethnopharmacol. 2013 May 2;147(1):208-14

[5]Zhang H, Li S, Lu J, Jin J, Zhu G, Wang L, Yan Y, He L, Wang B, Wang X, Yu H. α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice. Aging (Albany NY). 2021 Jul 8;13(13):17690-17706

[6]Luo M, Qiu J, Zhang Y, Wang J, Dong J, Li H, Leng B, Zhang Q, Dai X, Niu X, Zhao S, Deng X. α-cyperone alleviates lung cell injury caused by Staphylococcus aureus via attenuation of α-hemolysin expression. J Microbiol Biotechnol. 2012 Aug;22(8):1170-6

 

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