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Chemical Structure| 841301-32-4 Chemical Structure| 841301-32-4

Structure of Amenamevir
CAS No.: 841301-32-4

Chemical Structure| 841301-32-4

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ASP 2151 is an inhibitor of herpes virus helicase-primase.

Synonyms: ASP 2151

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Product Details of Amenamevir

CAS No. :841301-32-4
Formula : C24H26N4O5S
M.W : 482.55
SMILES Code : O=C(C(CC1)CCS1(=O)=O)N(CC(NC2=CC=C(C3=NOC=N3)C=C2)=O)C4=C(C)C=CC=C4C
Synonyms :
ASP 2151
MDL No. :MFCD19443709
InChI Key :MNHNIVNAFBSLLX-UHFFFAOYSA-N
Pubchem ID :11397521

Safety of Amenamevir

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Vero cells 0.01 μM to 0.5 μM 2 to 3 days To screen for AMNV-resistant HSV-1 and HSV-2 mutants Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0049421
human embryonic lung fibroblast (HELF) cells 0.043 μM (HSV-1), 0.069 μM (HSV-2) To evaluate the inhibitory effect of ASP2151 on HSV-1 and HSV-2, results showed ASP2151 more potently inhibited viral replication than acyclovir (ACV). Antimicrob Agents Chemother. 2012 Jul;56(7):3587-91
Human embryonic fibroblast (HEF) cells 14 ng/ml (HSV-1) and 30 ng/ml (HSV-2) To evaluate the in vitro antiviral activity of ASP2151 against HSV-1 and HSV-2. Results showed that ASP2151 had EC50 values of 14 ng/ml for HSV-1 and 30 ng/ml for HSV-2, significantly lower than those of acyclovir (ACV). Antimicrob Agents Chemother. 2013 Mar;57(3):1339-46

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.07mL

0.41mL

0.21mL

10.36mL

2.07mL

1.04mL

20.72mL

4.14mL

2.07mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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