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Limited Quantity USD 15-60
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Chemical Structure| 54-96-6 Chemical Structure| 54-96-6

Structure of Amifampridine
CAS No.: 54-96-6

Chemical Structure| 54-96-6

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Amifampridine is a quaternary ammonium compound that blocks presynaptic potassium channels, subsequently prolongs the action potential and increases presynaptic calcium concentrations, it was approved by the US FDA for the treatment of adults with LEMS.

Synonyms: 3,4-Diaminopyridine

4.5 *For Research Use Only !

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Product Details of Amifampridine

CAS No. :54-96-6
Formula : C5H7N3
M.W : 109.13
SMILES Code : C1=CN=CC(=C1N)N
Synonyms :
3,4-Diaminopyridine
MDL No. :MFCD00006401
InChI Key :OYTKINVCDFNREN-UHFFFAOYSA-N
Pubchem ID :5918

Safety of Amifampridine

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H300+H330-H311-H315-H319-H335
Precautionary Statements:P260-P264-P280-P284-P301+P310-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Description
Amifampridine (3,4-Diaminopyridine) is an orally active, potent, and cell-permeable blocker of voltage-gated potassium (Kv) channels. It is effective in reversing BoNT/A intoxication, enhancing transmitter release from neuromuscular junctions (NMJs), and can be utilized in research related to Lambert-Eaton myasthenic syndrome (LEMS)[1][2][3].

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT05123053 Vocal Weakness(Post-BOTOX Inje... More >>ction) Less << PHASE2 RECRUITING 2023-12-30 Augusta University, Augusta, G... More >>eorgia, 30912, United States Less <<
NCT03062631 Congenital Myasthenic Syndrome NO_LONGER_AVAILABLE - University of California, Davi... More >>s Medical Center, Sacramento, California, 95817, United States Less <<
NCT05769478 Botulism|Iatrogenic Botulism PHASE1 COMPLETED 2024-10-29 Wake Forest University Health ... More >>Sciences, Winston-Salem, North Carolina, 27157, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

9.16mL

1.83mL

0.92mL

45.82mL

9.16mL

4.58mL

91.63mL

18.33mL

9.16mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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