Structure of Amorolfine HCl
CAS No.: 78613-38-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Amorolfine HCl is a morpholine antifungal drug working by inhibiting Δ-sterol reductase.
Synonyms: Ro 14-4767/002; Amorolfine (hydrochloride); Ro 14-4767 HCl
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 78613-38-4 |
Formula : | C21H36ClNO |
M.W : | 353.97 |
SMILES Code : | C[C@@H]1O[C@H](C)CN(CC(C)CC2=CC=C(C(C)(C)CC)C=C2)C1.[H]Cl |
Synonyms : |
Ro 14-4767/002; Amorolfine (hydrochloride); Ro 14-4767 HCl
|
MDL No. : | MFCD00903738 |
InChI Key : | XZKWIPVTHGWDCF-KUZYQSSXSA-N |
Pubchem ID : | 54259 |
GHS Pictogram: |
![]() ![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H302-H319-H372-H410 |
Precautionary Statements: | P501-P273-P260-P270-P264-P280-P391-P314-P337+P313-P305+P351+P338-P301+P312+P330 |
Class: | 9 |
UN#: | 3077 |
Packing Group: | Ⅲ |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02321098 | Foot Dermatoses | Phase 4 | Completed | - | Iceland ... More >> Principal Investigator Reykjavik, Iceland Less << |
NCT03289871 | Onychomycosis | Not Applicable | Completed | - | Tunisia ... More >> Hospital Habib Thameur Tunis, Tunisia Principal instruction military hospital Tunis, Tunisia Less << |
NCT03382717 | Onychomycosis of Toenail | Not Applicable | Completed | - | Tunisia ... More >> Hospital Habib Thameur Tunis, Tunisia Principal instruction military hospital Tunis, Tunisia Less << |
NCT02321098 | - | Completed | - | - | |
NCT00938925 | Onychomycosis | Phase 1 | Suspended(No funds) | March 2017 | Spain ... More >> School Health Sciences, University of Malaga Malaga, Málaga, Spain, 29009 Antonio Cuesta-vargas Malaga, Spain, 29009 Health Science School , University of Malaga Malaga, Spain, 29009 Less << |
NCT02679911 | Foot Dermatoses | Phase 4 | Completed | - | Germany ... More >> Tübingen, Germany Less << |
NCT02549001 | Onychomycosis | Phase 3 | Completed | - | Belgium ... More >> Polichem Investigative Site Multiple Locations, Belgium Bulgaria Polichem Investigative Site Multiple Locations, Bulgaria Czechia Polichem Investigative Site Multiple Locations, Czechia Germany Polichem Investigative Site Multiple Locations, Germany Greece Polichem Investigative Site Multiple Locations, Greece Hungary Polichem Investigative Site Multiple Locations, Hungary Iceland Polichem Investigative Site Various Cities In Iceland, Iceland Latvia Polichem Investigative Site Multiple Locations, Latvia Lithuania Polichem Investigative Site Multiple Locations, Lithuania Poland Polichem Investigative Site Multiple Locations, Poland Russian Federation Polichem Investigative Site Multiple Locations, Russian Federation Slovakia Polichem Investigative Site Multiple Locations, Slovakia Sweden Polichem Investigative Site Multiple Locations, Sweden Less << |
NCT02679911 | - | Completed | - | - | |
NCT02705664 | Foot Dermatoses | Phase 4 | Completed | - | Iceland ... More >> Principal Investigator Reykjavik, Iceland Less << |
NCT01528813 | Onychomycosis | Phase 2 | Unknown | December 2013 | Brazil ... More >> University Hospital of Brasilia Recruiting Brasilia, Federal District, Brazil, 70910-900 Contact: Orlando O Morais, M.D. +55(61)99162339 orlando.unb@gmail.com Principal Investigator: Orlando O Morais, M.D. Less << |
NCT00459537 | Onychomycosis | Phase 3 | Completed | - | Finland ... More >> Novartis Investigative Site Various Cities, Finland France Novartis Investigative Site Various Cities, France Germany Novartis Investigative Site Various Cities, Germany Hungary Novartis Investigative Site Various Cities, Hungary Iceland Novartis Investigative Site Various Cities, Iceland Norway Novartis Investigative Site Various Cities, Norway Poland Novartis Investigative Site Various Cities, Poland Russian Federation Novartis Investigative Site Various Cities, Russian Federation Spain Novartis Investigative Site Various Cities, Spain Turkey Novartis Investigative Site Various Cities, Turkey Less << |
NCT03098342 | Onychomycosis of Toenail | Not Applicable | Not yet recruiting | January 31, 2019 | Thailand ... More >> King Chulalongkorn Memorial Hospital Not yet recruiting Bangkok, Thailand, 10330 Contact: Nutthamon Bowornsathitchai, M.D. 66818239488 bee_o_bo@hotmail.com Contact: Jaruwan Pemcharoen, B.Sc. 66823573912 photochulateam@gmail.com Sub-Investigator: Anukorn Sriaram, B.Eng. Less << |
NCT00459537 | - | Completed | - | - | |
NCT01014637 | Onychomycosis | Phase 4 | Unknown | September 2011 | France ... More >> Cabinet Médical Recruiting Argenteuil, France, 95100 Principal Investigator: Yves LE CORRE, MD Cabinet Médical Recruiting Brest, France, 29200 Principal Investigator: Monique CHASSAIN LE LAY, MD Cabinet Medical Recruiting Cholet, France, 49300 Principal Investigator: Jean-Michel DEBARRE, MD Cabinet Médical Recruiting Martigues, France, 13500 Principal Investigator: Mireille RUER-MULLARD, MD Cabinet Médical Recruiting Nice, France, 06000 Principal Investigator: Gilles ROSTAIN, MD Cabinet Médical Recruiting Toulouse, France, 31000 Principal Investigator: Didier COUSTOU, MD Hopital Purpan Not yet recruiting Toulouse, France Principal Investigator: Carle PAUL, Professor Less << |
NCT01851590 | Onychomycosis | Phase 4 | Completed | - | Finland ... More >> Vääksyn Lääkärikeskus Vääksy, Finland, FI-17200 Less << |
NCT02812043 | Non-dermatophyte Onychomycosis | Phase 4 | Recruiting | August 2018 | Thailand ... More >> Department of Dermatology Siriraj Hospital Recruiting Bangkoknoi, Bangkok, Thailand, 10700 Contact: Charussri Leeyaphan, MD 6624194333 charussrilee@gmail.com Less << |
NCT01929187 | Onycomycosis | Not Applicable | Unknown | July 2014 | Taiwan ... More >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Chiu-Nun Chen +886+2-23562141 derm@ntuh.gov.tw Principal Investigator: Jin-Bon Hong, MD Less << |
NCT01851590 | - | Completed | - | - |
[1]Polak A. Preclinical data and mode of action of amorolfine. Dermatology. 1992;184 Suppl 1:3-7.
[3]Polak A. Preclinical data and mode of action of amorolfine. Dermatology. 1992;184 Suppl 1:3‐7
Tags: Amorolfine HCl | Ro 14-4767/002 | Antifungal | Anti-Infection | 78613-38-4
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Code | Phrase |
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P102 | Keep out of reach of children. |
P103 | Read label before use |
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Code | Phrase |
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P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
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P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
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P401 | |
P402 | Store in a dry place. |
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P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
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P502 | Refer to manufacturer/supplier for information on recovery/recycling |
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H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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