Amphotericin B is a broad-spectrum antifungal agent that interferes with membrane permeability by binding to ergosterol in fungal cell membranes. Amphotericin B is mainly used for the treatment of systemic fungal infections, such as candidiasis and aspergillosis.

Synonyms: LNS-AmB; NSC 527017; Fungizone

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Quality Control of Amphotericin B Purity: ≥750 μg/mg SDS Specification

COA

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NMR

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CNMR

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Product Details of Amphotericin B

CAS No. :	1397-89-3
Formula :	C₄₇H₇₃NO₁₇
M.W :	924.08
SMILES Code :	C[C@H]([C@@H](O)[C@@H](C)[C@H](C)OC1=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@]2([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C1)(O)O3
Synonyms :	LNS-AmB; NSC 527017; Fungizone
MDL No. :	MFCD00877763

Safety of Amphotericin B

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of Amphotericin B

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1397-89-3 ]

[ 1397-89-3 ] Synthesis Path-Downstream 1~35

1
[ 1445-45-0 ]
[ 1397-89-3 ]
[ 105190-34-9 ]
[ 105190-34-9 ]

References: [1]Tetrahedron Letters,1988,vol. 29,p. 447-450.

2
[ 1397-89-3 ]
arabinogalactan [ No CAS ]
unreduced amphotericin B-arabinogalactan [ No CAS ]

References: [1]Antimicrobial Agents and Chemotherapy,1999,vol. 43,p. 2209 - 2214.

3
[ 911368-25-7 ]
[ 1397-89-3 ]
[ 911368-28-0 ]

References: [1]Journal of the American Chemical Society,2006,vol. 128,p. 11977 - 11984.

4
C₁₉⁽¹³⁾CH₂₀N⁽¹⁵⁾NO₄ [ No CAS ]
[ 1397-89-3 ]
C₆₆⁽¹³⁾CH₉₃N₂⁽¹⁵⁾NO₂₀ [ No CAS ]

References: [1]Journal of the American Chemical Society,2006,vol. 128,p. 11977 - 11984.

5
[ 1397-89-3 ]
Gum arabic [ No CAS ]
amphotericin B-gum arabic imine conjugate [ No CAS ]

References: [1]Pharmaceutical Research,2007,vol. 24,p. 971 - 980.

6
4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[N^ε-(4-formylphenyl-carbonyl)-L-lysine], block copolymer, M_w = 15500, M_w/M_n = 1.18 [ No CAS ]
[ 1397-89-3 ]
4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[N^ε-(4-formylphenyl-carbonyl)-L-lysine] amphotericin B Schiff's base, block copolymer, M_w = 26700, M_w/M_n = 1.11 [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 2554 - 2557.

7
4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[N^ε-(4-formylphenyl-carbonyl)-L-lysine] amphotericin B Schiff's base, block copolymer, M_w = 26700, M_w/M_n = 1.11 [ No CAS ]
[ 1397-89-3 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 2554 - 2557.

8
[ 1397-89-3 ]
[ 111-30-8 ]
C₅₂H₈₁NO₁₇ [ No CAS ]

References: [1]Organic and Biomolecular Chemistry,2007,vol. 5,p. 1339 - 1342.

9
[ 1397-89-3 ]
[ 125697-63-4 ]
[ 942412-22-8 ]

References: [1]Organic and Biomolecular Chemistry,2007,vol. 5,p. 1339 - 1342.

10
C₂₇H₃₂N₂O₅ [ No CAS ]
[ 1397-89-3 ]
[ 942412-25-1 ]

References: [1]Organic and Biomolecular Chemistry,2007,vol. 5,p. 1339 - 1342.

11
N-(4-carboxybenzylidene)amphotericin B [ No CAS ]
[ 1397-89-3 ]