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Chemical Structure| 2417674-27-0 Chemical Structure| 2417674-27-0

Structure of AMPK-IN-3
CAS No.: 2417674-27-0

Chemical Structure| 2417674-27-0

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AMPK-IN-3 is a selective AMPK inhibitor with IC50 values of 60.7 nM and 107 nM, showing weak inhibition of KDR. It is used to study energy metabolism pathways in cancer without inducing significant cytotoxicity.

Synonyms: AMPK-IN-3

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Product Details of AMPK-IN-3

CAS No. :2417674-27-0
Formula : C25H33N5O3
M.W : 451.56
SMILES Code : O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(CCC(N)=O)C=C3)=O)=C1C)NCCN(CC)CC
Synonyms :
AMPK-IN-3
MDL No. :MFCD34676664

Safety of AMPK-IN-3

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of AMPK-IN-3

epigenetics
PI3K-AKT

Isoform Comparison

Biological Activity

Description
AMPK-IN-3 is an effective and specific inhibitor of AMPK, exhibiting IC50 values of 60.7 nM for AMPK (α2), 107 nM for AMPK (α1), and 3820 nM for KDR. Its inhibition of AMPK does not compromise the viability of K562 cells nor does it induce notable cytotoxic effects. This makes AMPK-IN-3 suitable for cancer research[1].

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Bio Calculators
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1 mM

5 mM

10 mM

2.21mL

0.44mL

0.22mL

11.07mL

2.21mL

1.11mL

22.15mL

4.43mL

2.21mL

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