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Chemical Structure| 494-52-0 Chemical Structure| 494-52-0

Structure of Anabasine
CAS No.: 494-52-0

Chemical Structure| 494-52-0

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Anabasine is a bioactive alkaloid derived from tobacco, serving as a full agonist of nicotinic acetylcholine receptors (nAChRs) with an EC50 of 0.7 µM, inducing depolarization in TE671 cells. It is widely used in agriculture and biological pest control.

Synonyms: (S)-Anabasine; (+)-Anabasine; Anabazin

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Product Details of Anabasine

CAS No. :494-52-0
Formula : C10H14N2
M.W : 162.23
SMILES Code : C1(C=NC=CC=1)[C@@H]1CCCCN1
Synonyms :
(S)-Anabasine; (+)-Anabasine; Anabazin
MDL No. :MFCD00871391
InChI Key :MTXSIJUGVMTTMU-JTQLQIEISA-N
Pubchem ID :205586

Safety of Anabasine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Description
((S)-Anabasine) is a minor alkaloidal component in tobacco (Nicotiana) and functions as a full agonist at nicotinic acetylcholine receptors (nAChRs). It triggers depolarization in TE671 cells, which naturally express human fetal muscle-type nAChRs, with an EC50 value of 0.7 µM[1].[2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.16mL

1.23mL

0.62mL

30.82mL

6.16mL

3.08mL

61.64mL

12.33mL

6.16mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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