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Chemical Structure| 524708-03-0 Chemical Structure| 524708-03-0

Structure of APE1-IN-1
CAS No.: 524708-03-0

Chemical Structure| 524708-03-0

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APE1-IN-1 is an effective and brain-penetrant apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor with an IC50 of 2 μM. It enhances the cytotoxicity of alkylating agents methylmethane sulfonate and temozolomide in cancer cells.

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Product Details of APE1-IN-1

CAS No. :524708-03-0
Formula : C19H21N3OS2
M.W : 371.52
SMILES Code : CC(NC(S1)=C(C2=NC3=CC=CC=C3S2)C4=C1CN(C(C)C)CC4)=O
MDL No. :MFCD11984329

Safety of APE1-IN-1

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of APE1-IN-1

DNA

Isoform Comparison

Biological Activity

Description
APE1-IN-1 is a potent inhibitor of apurinic/apyrimidinic (AP) endonuclease 1 (APE1) that crosses the blood-brain barrier (BBB) and has an IC50 of 2 μM. It enhances the cytotoxic effects of the alkylating agents methylmethane sulfonate and temozolomide in cancer cells[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.46mL

2.69mL

1.35mL

26.92mL

5.38mL

2.69mL

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