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Chemical Structure| 541550-19-0 Chemical Structure| 541550-19-0

Structure of Apilimod
CAS No.: 541550-19-0

Chemical Structure| 541550-19-0

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Apilimod (STA 5326) acts as a potent IL-12/IL-23 inhibitor, strongly inhibiting IL-12 with IC50s of 1 nM and 2 nM in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively. It also serves as a potent and highly selective PIKfyve inhibitor.

Synonyms: STA 5326; LAM-002A free base; AIT-101

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Product Details of Apilimod

CAS No. :541550-19-0
Formula : C23H26N6O2
M.W : 418.49
SMILES Code : CC1=CC(/C=N/NC2=NC(OCCC3=NC=CC=C3)=NC(N4CCOCC4)=C2)=CC=C1
Synonyms :
STA 5326; LAM-002A free base; AIT-101
MDL No. :MFCD09954108

Safety of Apilimod

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of Apilimod

PI3K-AKT

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02594384 Lymphoma, Non-Hodgkin; Leukema... More >>i, Chronic Lymphocytic Less << Phase 1 Recruiting December 2019 United States, Alabama ... More >> Clearview Cancer Institute Recruiting Huntsville, Alabama, United States, 35805 Contact: Avitra Bone, RN    256-705-4283    studycoordinator@ccihsv.com    Principal Investigator: Marshall Schreeder, MD          United States, Florida Mayo Clinic Recruiting Jacksonville, Florida, United States, 32224 Contact: Lisa Melfi    904-953-3320    melfi.lisa@mayo.edu    Principal Investigator: Taimur Sher, MD          United States, Georgia Winship Cancer Institute at Emory University Recruiting Atlanta, Georgia, United States, 30322 Contact: Kaylan Dixon    404-778-4449    kaylan.dixon@emory.edu    Principal Investigator: Jonathan Cohen, MD          United States, Indiana Horizon Oncology Research, Inc. Recruiting Lafayette, Indiana, United States, 47905 Contact: Wael A Harb, MD    765-446-5111    wharb@horizonbioadvance.com    Principal Investigator: Wael A Harb, MD          United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Lauren Ramos    617-643-9607    lramos7@mgh.harvard.edu    Principal Investigator: Jeremy Abramson, MD          United States, Minnesota Mayo Clinic Recruiting Rochester, Minnesota, United States, 55905 Contact: Corinne Parker    507-266-3784    parker.corinne@mayo.edu    Principal Investigator: Stephen Ansell, MD          United States, New York New York University School of Medicine Recruiting New York, New York, United States, 10016 Contact: Ion Marinescu    646-501-7920    Ion.Marinescu@nyumc.org    Principal Investigator: Catherine Diefenbach, MD          Weill Cornell Medical College Recruiting New York, New York, United States, 10021 Contact: Rita Gazivoda    212-746-0702    rig9021@med.cornell.edu    Principal Investigator: Sarah Rutherford, MD          United States, Texas University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Linda Claret    713-792-1044    lcclaret@mdanderson.org    Principal Investigator: Loretta Nastoupil, MD          United States, Virginia Virginia Cancer Specialists Recruiting Fairfax, Virginia, United States, 22031 Contact: VCS Phase 1 Team    703-208-3192    Karin.Choquette@usoncology.com    Principal Investigator: Dipti Patel-Donnelly, MD          United States, Washington Virginia Mason Medical Center Recruiting Seattle, Washington, United States, 98101 Contact: Anas Najjar    206-287-5671    Anas.Najjar@virginiamason.org    Principal Investigator: David Aboulafia, MD Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.39mL

0.48mL

0.24mL

11.95mL

2.39mL

1.19mL

23.90mL

4.78mL

2.39mL

References

 

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