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Chemical Structure| 608141-41-9 Chemical Structure| 608141-41-9

Structure of Apremilast
CAS No.: 608141-41-9

Chemical Structure| 608141-41-9

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Apremilast is a small molecule inhibitor of PDE4 with an IC50 value of 74 nM.

Synonyms: CC-10004; APR

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Product Details of Apremilast

CAS No. :608141-41-9
Formula : C22H24N2O7S
M.W : 460.50
SMILES Code : CC(NC1=CC=CC(C(N2[C@@H](C3=CC=C(OC)C(OCC)=C3)CS(=O)(C)=O)=O)=C1C2=O)=O
Synonyms :
CC-10004; APR
MDL No. :MFCD18782607
InChI Key :IMOZEMNVLZVGJZ-QGZVFWFLSA-N
Pubchem ID :11561674

Safety of Apremilast

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H361
Precautionary Statements:P501-P202-P201-P280-P308+P313-P405

Isoform Comparison

Biological Activity

Target
  • TNF-α

    TNF-α, IC50:77 nM

  • PDE4

    PDE4, IC50:74 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
Xenopus laevis oocytes 1–10 μM Apremilast did not directly alter GABA A receptor function PMC7544627
Natural killer (NK) cells 10 μM 48 h Inhibited NK cell production of TNF-α and GM-CSF PMC2829210
Polymorphonuclear cells (PMN) 94 nM (IC50) 18 h Inhibited PMN production of IL-8 PMC2829210
Draining lymph node cells 200 nM 72 h To evaluate the effect of apremilast on balancing Treg and Teff cells. Results showed that apremilast significantly suppressed Th17 and Th1 cells and enhanced the proportion and population of Treg cells. PMC7705241
CD4+CD25+ regulatory T cells 0.1 µM 24 h To evaluate Apremilast's effect on Treg stability and conversion to Th17 cells. Results showed Apremilast pretreatment significantly increased Foxp3 expression, decreased IL-17a and CD126 expression, and maintained Treg suppressive function. PMC6058600
ATDC5 chondrocytes 1 µM 7 days Apremilast suppressed IL-17-induced cellular senescence, reducing SA-β-gal activity. PMC7834959
ATDC5 chondrocytes 0.5 and 1 µM 24 h Apremilast reduced the expression and secretion of IL-1β and MCP-1 induced by IL-17 in a dose-dependent manner. PMC7834959
Human neonatal foreskin epidermal keratinocytes (HEKn cells) 1 μM 18 h Inhibited UVB light-activated keratinocyte production of TNF-α PMC2829210
Peripheral blood mononuclear cells (PBMC) 10 μM 18 h Inhibited PBMC production of the chemokines CXCL9 and CXCL10, cytokines interferon-γ and tumour necrosis factor (TNF)-α, and interleukins (IL)-2, IL-12 and IL-23 PMC2829210
Raw264.7 monocytic murine cell line 104 nM (IC50) 30 min Apremilast increased intracellular cAMP and inhibited TNF-α release with an IC50 of 104 nM. PMC4570588

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6J mice BLM-induced systemic sclerosis (SSc) model Oral 25 mg/kg and 5 mg/kg Once daily for 4 consecutive weeks Apremilast significantly ameliorated the pathological manifestations of SSc, including skin dermal thickness, deposition of collagens, and increased expression of α-SMA PMC8791980
C57BL/6J mice Experimental autoimmune uveitis (EAU) model Oral gavage 15 mg/kg Once daily for 14 days (from day 7 to day 21 after immunization) To evaluate the therapeutic effect of apremilast on EAU. Results showed that apremilast significantly reduced vascular leakage, macular edema, and inflammatory cell infiltration in the retina, corresponding to decreased clinical and pathological scores. Additionally, apremilast decreased the proportion and population of Th17 cells and increased the proportion and population of Treg cells. PMC7705241
DBA/1J mice Collagen-induced arthritis (CIA) model Oral 5 mg/kg or 25 mg/kg Once daily for 10 consecutive days To assess therapeutic effects of Apremilast in CIA. Results demonstrated delayed arthritis onset, reduced clinical scores, decreased anti-CII antibodies, prevented bone erosion, and modulated Th1/Th17/Treg balance (decreased Th17/Th1, increased Treg). High dose (25 mg/kg) showed superior efficacy. PMC6058600
Beige-severe combined immunodeficient mice Mouse model xenotransplanted with normal human skin and triggered with human psoriatic NK cells Oral 5 mg/kg Twice daily for 14 days Significantly reduced epidermal thickness and proliferation, decreased the general histopathological appearance of psoriasiform features and reduced expression of TNF-α, human leukocyte antigen-DR and intercellular adhesion molecule-1 in the lesioned skin PMC2829210
C57BL/6J mice Models of ethanol- and other GABAergic drug-induced sedative-hypnotic effects and ataxia Oral 20 mg/kg Once daily for 1 hour Apremilast prolonged the sedative-hypnotic effects of ethanol, gaboxadol, zolpidem, and propofol and prolonged recovery from ataxia induced by ethanol, zolpidem, propofol, and loreclezole, but shortened the sedative-hypnotic and ataxic effects of diazepam. The PKA inhibitor H89 blocked these modulatory effects of apremilast. PMC7544627
Mice Β3-S408A/S409A knock-in mice Oral 20 mg/kg Once daily for 1 hour Apremilast increases acute sensitivity to alcohol, decreases AFT, and decreases ethanol drinking through PKA-dependent phosphorylation of β3 GABA A receptor subunits PMC9810330
Mice Murine air pouch model Oral 5 mg/kg 24 hours and 1 hour before inflammation induction Apremilast significantly inhibited TNF-α production in the air pouch by 39% and reduced leukocyte count by 28%. PMC4570588

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT04175613 Psoriasis PHASE3 ACTIVE_NOT_RECRUITING 2027-02-22 Phoenix Childrens Hospital, Ph... More >>oenix, Arizona, 85016, United States|Johnson Dermatology Clinic, Fort Smith, Arkansas, 72916, United States|First OC Dermatology, Irvine, California, 92697, United States|Stanford University School of Medicine, Palo Alto, California, 94304, United States|California Dermatology Institute, Thousand Oaks, California, 91320, United States|Solutions Through Advanced Research Inc, Jacksonville, Florida, 32256, United States|Ciocca Dermatology, Miami, Florida, 33173, United States|Skin Care Physicians of Georgia, Macon, Georgia, 31217, United States|Dawes Fretzin Dermatology Group Inc, Indianapolis, Indiana, 46256, United States|Wright State Physicians, Fairborn, Ohio, 45324, United States|Medical University of South Carolina, Charleston, South Carolina, 29425, United States|Driscoll Childrens Hospital, San Antonio, Texas, 78218, United States|University of Wisconsin Hospital and Clinics, Madison, Wisconsin, 53715-1375, United States|Centre Hospitalier Universitaire Saint Pierre, Brussels, 1000, Belgium|Cliniques Universitaires Saint Luc, Brussels, 1200, Belgium|Universitair Ziekenhuis Gent, Gent, 9000, Belgium|Stollery Childrens Hospital, Edmonton, Alberta, T6G 2B7, Canada|Winnipeg Clinic Dermatology Research, Winnipeg, Manitoba, R3C 0N2, Canada|Karma Clinical Trials, St. John's, Newfoundland and Labrador, A1C 2H5, Canada|AvantDerm, Toronto, Ontario, M5A 3R6, Canada|Fakultni nemocnice Kralovske Vinohrady, Praha 10, 100 34, Czechia|Synexus Czech sro, Praha, 120 00, Czechia|Cabinet du Docteur Ruer-Mulard Mireille, Martigues, 13500, France|Centre Hospitalier Universitaire de Toulouse - Hopital Larrey, Toulouse, 31400, France|Soroka University Medical Center, Bear Sheva, 8410101, Israel|Azienda Ospedaliero Universitaria Di Cagliari, Cagliari, 09124, Italy|Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, 20122, Italy|Azienda Ospedaliera di Padova, Padova, 35020, Italy|Altai State Medical University, Barnaul, 656038, Russian Federation|Chelyabinsk Regional Clinical Skin and Venereal Dispensary, Chelyabinsk, 454048, Russian Federation|Ural Scientific Research Institute of Dermatovenereology and Immunopathology, Ekaterinburg, 620076, Russian Federation|Republican Clinical Dermatology and Venerology Dispensary, Kazan, 420012, Russian Federation|Clinical Dispensary of Dermatology and Venereology of Krasnodar Territory of the Ministry of Health, Krasnodar, 350020, Russian Federation|State Scientific Center for Dermatovenereology and Cosmetology, Moscow, 107076, Russian Federation|Moscow Scientific Practical Center of Dermatology Venerology and Cosmetology, Moscow, 119071, Russian Federation|National Medical Research Center for Children Health, Moscow, 119991, Russian Federation|LLC Medical Center Zdorovaya Semiya, Novosibirsk, 630099, Russian Federation|Pierre Wolkenshtein Skin Diseases Clinic LLC, Saint Petersburg, 191123, Russian Federation|Saint Petersburg State Pediatric Medical University, Saint Petersburg, 194100, Russian Federation|LLC PiterKlinika, Saint Petersburg, 196158, Russian Federation|Bashkiria State Medical University, Ufa, 450083, Russian Federation|Yarosavl State Medical Academy, Yaroslavl, 150000, Russian Federation|Hospital Sant Joan de Deu, Esplugues de Llobregat, Catalu?a, 08950, Spain|General University Hospital of Alicante, Alicante, 3010, Spain|Hopsital Germans Trias I Pujol, Badalona, 08916, Spain|Hospital General Universitario Gregorio Maranon, Madrid, 28007, Spain|Hospital Infantil Universitario Nino Jesus, Madrid, 28009, Spain|Hospital 12 de Octubre, Madrid, 28041, Spain|Hospital La Paz, Madrid, 28046, Spain|Hospital Marques de Valdecilla, Santander, 39008, Spain Less <<
NCT05863273 Psoriasis NOT_YET_RECRUITING 2024-12-31 China-Japan Friendship Hospita... More >>l, Beijing, China|the First Hospital of China Medical University, Shenyang, 110001, China Less <<
NCT00869089 Prurigo Nodularis PHASE2 COMPLETED 2025-01-11 University Hospitals Cleveland... More >> Medical Center, Cleveland, Ohio, 44106, United States Less <<
NCT03000309 Plaque Psoriasis PHASE4 COMPLETED 2018-04-25 DermResearch, PLLC, Louisville... More >>, Kentucky, 40217, United States Less <<
NCT03422640 Frontal Fibrosing Alopecia PHASE4 UNKNOWN 2025-01-19 Bellevue Dermatology, Bellevue... More >>, Washington, 98004, United States Less <<
NCT03191539 Arthritis; Psoriasis (Etiology... More >>) Less << PHASE3 UNKNOWN 2019-06-14 -
NCT05565560 Plaque Psoriasis PHASE3 RECRUITING 2026-09-06 Nagoya City University Hospita... More >>l, Nagoya-shi, Aichi, 467-8602, Japan|Fukuoka University Hospital, Fukuoka-shi, Fukuoka, 814-0180, Japan|Hospital of the University of Occupational and Environmental Health Japan, Kitakyushu-shi, Fukuoka, 807-8556, Japan|Kurume University Hospital, Kurume-shi, Fukuoka, 830-0011, Japan|Fukushima Medical University Hospital, Fukushima-shi, Fukushima, 960-1295, Japan|Gifu University Hospital, Gifu-shi, Gifu, 501-1194, Japan|Gunma University Hospital, Maebashi-shi, Gunma, 371-8511, Japan|Takagi Dermatological Clinic, Obihiro-shi, Hokkaido, 080-0013, Japan|Hokkaido University Hospital, Sapporo-shi, Hokkaido, 060-8648, Japan|Kanazawa Medical University Hospital, Kahoku-gun, Ishikawa, 920-0293, Japan|Takeoka Dermatology Clinic, Marugame-shi, Kagawa, 763-0074, Japan|Takamatsu Red Cross Hospital, Takamatsu-shi, Kagawa, 760-0017, Japan|Saruwatari Dermatology Clinic, Kagoshima-shi, Kagoshima, 890-0046, Japan|Tokai University Hospital, Isehara-shi, Kanagawa, 259-1193, Japan|St Marianna University Hospital, Kawasaki-shi, Kanagawa, 216-8511, Japan|University Hospital Kyoto Prefectural University of Medicine, Kyoto-shi, Kyoto, 602-8566, Japan|Shinshu University Hospital, Matsumoto-shi, Nagano, 390-8621, Japan|Nagasaki University Hospital, Nagasaki-shi, Nagasaki, 852-8501, Japan|University of the Ryukyus Hospital, Ginowan-shi, Okinawa, 901-2725, Japan|Kansai Medical University Hospital, Hirakata-shi, Osaka, 573-1191, Japan|Nippon Life Hospital, Osaka-shi, Osaka, 550-0006, Japan|Kindai University Hospital, Osakasayama-shi, Osaka, 589-8511, Japan|Dokkyo Medical University Hospital, Shimotsuga-gun, Tochigi, 321-0293, Japan|Sugai Dermatology Park Side Clinic, Utsunomiya-shi, Tochigi, 321-0954, Japan|St Lukes International Hospital, Chuo-ku, Tokyo, 104-8560, Japan|Teikyo University Hospital, Itabashi-ku, Tokyo, 173-8606, Japan|Mita Dermatology Clinic, Minato-ku, Tokyo, 108-0014, Japan|Seibo International Catholic Hospital, Shinjuku-ku, Tokyo, 161-8521, Japan|Tokyo Medical University Hospital, Shinjyuku-ku, 160-0023, Japan Less <<
NCT01634178 Healthy Volunteer PHASE1 COMPLETED 2012-03-01 PPD Development, Austin, Texas... More >>, 787844, United States Less <<
NCT04161456 Acne Conglobata PHASE2 COMPLETED 2021-02-08 University Hospital Frankfurt,... More >> Frankfurt, Hessia, 60590, Germany Less <<
NCT03608657 Arthritis, Psoriatic COMPLETED 2022-03-30 The Waterside Clinic, Barrie, ... More >>L4M 6L2, Canada|The Arthritis and Osteoporosis Centre, Burlington, L7L 0B7, Canada|Adachi Medicine Professional Corporation, Hamilton, L8N 1Y2, Canada|Credit Valley Rheumatology, Mississauga, L5M 2V8, Canada|Institut de Recherche en Rhumatologie de Montréal, Montreal, H2L 1S6, Canada|Applied Medical Informatics Research Inc. (A.M.I.R.), Montreal, H4A 3T2, Canada|Brent Appleton Clinic New Westminster, New Westminster, V6Z 2C7, Canada|Dr. A. M. Jaroszynska Rheumatology and Osteoporosis Clinic, Oakville, L6M 4J2, Canada|Drs M&W Teo, Penticton, V2A 4Z1, Canada|Groupe de recherche en maladies osseuses Inc., Quebec, G1V 3M7, Canada|Centre de Rhumatologie de l'Est du Quebec, Rimouski, G5L 8W1, Canada|Polmed Research Inc., Saskatoon, S7N 4A4, Canada|Clinique Jacques Cartier, Sherbrooke, J1J 2E3, Canada|St. Clare's Mercy Hospital, St John's, A1A 5B8, Canada|Dr. Juris Lazovskis Incorporated, Sydney, B1S 3N1, Canada|Toronto Western Hospital, University Health Network, Toronto, M5T 2S8, Canada|Arthur Karasik Medicine Professional Inc., Toronto, M9C 5N2, Canada|Dr. Jonathan D. Chan Inc., Vancouver, V5Z 1J9, Canada|Dr. Sabeen Anwar Medicine Professional Corporation, Windsor, N8X 5A6, Canada Less <<
NCT02576678 Psoriasis PHASE2 COMPLETED 2019-07-29 Rady Children's Hospital, San ... More >>Diego, California, 92123, United States|Emory University, Atlanta, Georgia, 30322, United States|Ann & Robert H. Lurie Children's Hospital of Chicago Department of Dermatology, Chicago, Illinois, 60611, United States|Dundee Dermatology, West Dundee, Illinois, 60118, United States|Mount Sinai, St. Luke's, New York, New York, 10025, United States|Texas Dermatology and Laser Specialists, San Antonio, Texas, 78218, United States|Stollery Children's Hospital, Edmonton, Alberta, T6G 2B7, Canada|Nexus Clinical Research, St John's, Newfoundland and Labrador, A1A 5E8, Canada|CHU Saint-Justine, Montreal, Quebec, H3T 1C5, Canada|Rheinische Friedrich-Wilhelms-Universitaet Bonn - Universitaetsklinikum Bonn, Bonn, 53127, Germany|Universitatsklinikum Essen, Essen, 45147, Germany|Universitatsklinikum Klinikum Frankfurt Main, Frankfurt, 60590, Germany|Kinderkrankenhaus Wilhelmstift, Dermatologie, Hamburg, 22149, Germany|Universit?tsmedizin der Johannes Gutenberg-Universit?t Mainz, Mainz, 55131, Germany|Muenster University Hospital (Universit?tsklinikum Muenster), Munster, 48149, Germany|Hospital de la Santa Creu i Sant Pau, Barcelona, 08041, Spain|Hospital Sant Joan de Deu, Esplugues de Llobregat, 08950, Spain|Hospital La Paz, Madrid, 28046, Spain Less <<
NCT03828045 Arthritis, Psoriatic COMPLETED 2021-10-20 H Son Espases, Mallorca, Balea... More >>res, 07120b, Spain|H Son Llatzer, Mallorca, Baleares, 07198, Spain|H Univ Canarias, Tenerife, Canarias, 38320, Spain|H Parc Tauli, Barcelona, Catalu?a, 08208, Spain|H Bellvitge, L'Hospitalet Del Llobregat, Catalu?a, 8907, Spain|H Santa Maria Lleida, Lérida, Catalu?a, 25198, Spain|H Joan XXIII, Tarragona, Catalu?a, 43005, Spain|H Mérida, Badajoz, Extremadura, 06800, Spain|H Virgen del Puerto, Caceres, Extremadura, 10600, Spain|H Virgen de la Arrixaca, El Palmar, Murcia, 30120, Spain|H Navarra, Pamplona, Navarra, 31008, Spain|H Txagorritxu de Vitoria, Vitoria, País Vasco, 01009, Spain|H Perpetuo Socorro, Badajoz, 06010, Spain|H Del Mar, Barcelona, 08003, Spain|H Donostia, Donostia, 20014, Spain|H Can Misses, Eivissa, 07800, Spain|H Santa Lucía, Murcia, 30202, Spain|H Monte Naranco, Oviedo, 33012, Spain|H l Esperit Sant, Santa Coloma de Gramenet, 08923, Spain|Universitaire Vaudoise*, Vigo, 36213, Spain Less <<
NCT04572997 Palmoplantar Pustulosis PHASE2 COMPLETED 2019-08-29 University Hospital Bonn, Bonn... More >>, 53127, Germany|Universit?tsmedizin G?ttingen / Georg-August-Universit?t Department for Dermatology, Venereology and Allergology, G?ttingen, 37075, Germany|SCIderm GmbH, Hamburg-Harburg, 20354, Germany|Universit?tsklinik Schleswig-Holstein, Campus Kiel, PSORIASIS-ZENTRUM KIEL, Klinik für Dermatologie, Venerologie und Allergologie, Kiel, 24105, Germany|Universit?tsklinikum Münster Klinik für Hautkrankheiten, Münster, 48149, Germany Less <<
NCT03097003 Psoriasis COMPLETED 2018-12-20 AZ Sint Jan, Brugge, 8000, Bel... More >>gium|CHU St Pierre, Brussels, 1000, Belgium|CHU Brugmann (Victor Horta), Brussels, 1020, Belgium|Clin Univ de Bxl H?pital Erasme, Brussels, 1070, Belgium|UZ Brussel, Brussels, 1090, Belgium|Cliniques Universitaires St-Luc, Brussels, 1200, Belgium|UZ Antwerpen, Edegem, 2650, Belgium|Private Practice Geel, Geel, 2440, Belgium|Private Practice Genk, Genk, 3600, Belgium|AZ Sint Lucas, Gent, 9000, Belgium|UZ Gent, Gent, 9000, Belgium|CHU UCL Mont-Godinne, Godinne, 5530, Belgium|Clinique André Renard d'Herstal, Herstal, 4040, Belgium|Private Practice Lede, Lede, 9340, Belgium|UZ Leuven Sint Rafael, Leuven, 3000, Belgium|CHU Sart-Tilman, Liège, 4000, Belgium|GHdC - site IMTR, Loverval, 6280, Belgium|Dermatologie Maldegem, Malgegem, 9990, Belgium|Private Practice Mons, Mons, 7000, Belgium|Private Practice Namur, Namur, 5000, Belgium|Ste Elisabeth - Namur, Namur, 5000, Belgium|CH Bois Abbaye-Hesbaye, Seraing, 4100, Belgium Less <<
NCT03740516 Bechet's Disease NO_LONGER_AVAILABLE - Celgene, Summit, New Jersey, 0... More >>7901, United States Less <<
NCT03757013 Psoriasis COMPLETED 2021-09-10 Private Practice, Amiens, Amie... More >>ns, 80000, France|Saint-Joseph Clinic, Angouleme, Angouleme, 16000, France|Private Practice, Antibes, Antibes, 06600, France|Private Practice 2, Antony, Antony, 92160, France|Private Practice 2, Arcachon, Arcachon, 33120, France|Private Practice, Argenteuil, Argenteuil, 95100, France|Private Practice, Aubière, Aubière, 63170, France|Private Practice, Auch, Auch, 32000, France|Auxerre Hospital, Auxerre, 89000, France|Henri Duffaut Hospital, Avignon Cedex 9, 84902, France|Private Practice, Besan?on, Besan?on, 25000, France|Reims-Bezannes Polyclinic 2, Bezannes, 51430, France|Reims-Bezannes Polyclinic 3, Bezannes, 51430, France|Reims-Bezannes Polyclinic, Bezannes, 51430, France|Private Practice, Biarritz, Biarritz, 64200, France|Private Practice, Bordeaux, Bordeaux, 33000, France|Docteur Duchenne Hospital 2, Boulogne-sur-Mer, 62321, France|Docteur Duchenne Hospital, Boulogne-sur-Mer, 62321, France|Private Practice, Bègles, Bègles, 33130, France|Private Practice 2, Caen, Caen, 14000, France|Private Practice 3, Caen, Caen, 14000, France|Private Practice, Caen, Caen, 14000, France|Private Practice, Cannes, Cannes, 06400, France|Private Practice 2, Chalons-en-Champagne, Chalons-en -Champagne, 51000, France|Private Practice, Chalons-en-Champagne, Chalons-en-Champagne, 51000, France|Chalons-en-Champagne Hospital, Chalons-en-Champagne, 51005, France|Private Practice, Chamalières, Chamalières, 63400, France|Trousseau Hospital, Chambray-Les-Tours Cedex, 37171, France|Métropole Savoie Hospital, Chambéry, 73000, France|Private Practice 2, Chartres, Chartres, 28000, France|Private Practice, Chartres, Chartres, 28000, France|New Sud Francilien Hospital, Corbeil Essonnes, 91100, France|GH de Dax, Dax, Dax, 40107, France|Private Practice 2, Dijon, Dijon, 21000, France|Private Practice 3, Dijon, Dijon, 21000, France|Private Practice, Dijon, Dijon, 21000, France|Private Practice, Dole, Dole, 39100, France|Victor Jousselin Hospital, Dreux, 28102, France|Emile Durkheim Hospital - Saint Jean Health Center, Epinal Cedex, 88021, France|Private Practice, Essey-les-Nancy, Essey-les-Nancy, 54270, France|Golfe de St-Tropez Clinic, Gassin, 83580, France|Private Practice 2, Joue les Tours, Joue les Tours, 37300, France|Private Practice 3, Joue les Tours, Joue les Tours, 37300, France|Private Practice, Joue les Tours, Joue les Tours, 37300, France|Private Practice, L'Union, L'Union, 31240, France|Private Practice 2, La Teste-de-Buch, La Teste-de-Buch, 33260, France|Private Practice, La Teste-de-Buch, La Teste-de-Buch, 33260, France|Private Practice, La Valette du Var, La Valette du Var, 83160, France|Private Practice, La Varenne Saint Hilaire, La Varenne Saint Hilaire, 94210, France|Private Practice 2, Laval, Laval, 53000, France|Private Practice, Laval, Laval, 53000, France|Private Practice, Le Mans, Le Mans, 72000, France|Mans Hospital 2, Le Mans, 72037, France|Mans Hospital, Le Mans, 72037, France|Private Practice, Le-Bourget-du-Lac, Le-Bourget-du-Lac, 73370, France|Private Practice, Lille, Lille, 59000, France|Private Practice 2, Luce, Luce, 28110, France|Private Practice, Luce, Luce, 28110, France|Private Practice, Lyon, Lyon, 69002, France|Edouard Herriot Hospital, Lyon, 69003, France|Private Practice 2, Lyon, Lyon, 69006, France|Private Practice 4, Lyon, Lyon, 69008, France|Private Practice, Martigues, Martigues, 13500, France|Annecy Genevois Hospital, Metz Tessy, Metz Tessy, 74370, France|Private Practice, Meudon-la-Forêt, Meudon-la-Forêt, 92360, France|Private Practice, Muret, Muret, 31600, France|Hotel Dieu Hospital, Dermatologic Clinic, Nantes, 44093, France|Private Practice, Narbonne, Narbonne, 11100, France|Private Practice, Nevers, Nevers, 58000, France|Private Practice 2, Nice, Nice, 06000, France|Private Practice 3, Nice, Nice, 06000, France|Private Practice, Nogent-Le-Rotrou, Nogent-Le-Rotrou, 28400, France|Private Practice, Orléans, Orléans, 45000, France|Private Practice, Paris, Paris, 75005, France|Private Practice 2, Paris, Paris, 75006, France|Private Practice 3, Paris, Paris, 75008, France|Private Practice 4, Paris, Paris, 75009, France|Private Practice 5, Paris, Paris, 75010, France|Private Practice, Pontarlier, Pontarlier, 25300, France|Private Practice, Pontoise, Pontoise, 95300, France|Private Practice, Quimper, Quimper, 29000, France|CHI de Cornouaille - Laennec, Quimper, 29107, France|Mathilde II Clinic, Rouen, 76100, France|Private Practice, Saint-Etienne, Saint-Etienne, 42000, France|Saint-Etienne Hospital, St Priest en Jarez, 42277, France|Private Practice, Torcy, Torcy, 77200, France|BCRM Toulon - HIA Saint-Anne, Toulon Cedex 9, 83800, France|Private Practice, Toulouse, Toulouse, 31000, France|Nord Franche-Comté Hospital, Trevenans, 90400, France|Valence Hospital 2, Valence, 26953, France|Valence Hospital 3, Valence, 26953, France|Valence Hospital, Valence, 26953, France|Jacques Lacarin Hospital, Vichy, 03201, France Less <<
NCT03442088 Plaque Psoriasis PHASE2 COMPLETED 2021-09-30 University Hospitals Cleveland... More >> Medical Center, Cleveland, Ohio, 44106, United States Less <<
NCT05875714 Erythema Multiforme PHASE2 RECRUITING 2025-12-31 Perelman Center For Advanced M... More >>edicine, Philadelphia, Pennsylvania, 19104, United States Less <<
NCT01393158 Atopic Dermatitis PHASE2 COMPLETED 2025-07-11 -
NCT00931242 Atopic Dermatitis|Allergic Con... More >>tact Dermatitis Less << PHASE2 COMPLETED 2025-03-10 Tufts Medical Center, Departme... More >>nt of Dermatology, Boston, Massachusetts, 02111, United States Less <<
NCT01140503 Dermatomyositis TERMINATED 2025-09-11 Stanford University School of ... More >>Medicine, Stanford, California, 94305, United States Less <<
NCT02695212 Hidradenitis Suppurativa PHASE2 COMPLETED 2025-08-17 Florida Academic Dermatology C... More >>enters, Coral Gables, Florida, 33134, United States Less <<
NCT01634191 Healthy Volunteer PHASE1 COMPLETED 2012-04-01 PRA International, Lenexa, Kan... More >>sas, 66219, United States|Clinical Development Services, Dallas, Texas, 75247, United States Less <<
NCT03082729 Psoriasis|Cardiovascular Disea... More >>ses Less << PHASE4 COMPLETED 2021-08-17 University of Southern Califor... More >>nia, Los Angeles, California, 90033, United States|Derm Associates, P.C., Rockville, Maryland, 20850, United States|Buffalo Medical Group, P.C., Buffalo, New York, 14221, United States|Oregon Medical Research Center, Portland, Oregon, 97223, United States|Dermatology and Skin Surgery Center, Exton, Pennsylvania, 19341, United States|The University of Pennsylvania, Philadelphia, Pennsylvania, 19140, United States|Center for Clinical Studies, Houston, Texas, 77004, United States Less <<
NCT03783026 Psoriatic Arthritis PHASE4 COMPLETED 2022-05-11 The Doctors of Saint John's Me... More >>dical Group, Santa Monica, California, 90404, United States|Inland Rheumatology Clinical Trials Inc, Upland, California, 91786, United States|Malcom Randall VA Medical Center, Gainesville, Florida, 32610, United States|Integral Rheumatology and Immunology Specialists, Plantation, Florida, 33324, United States|NYU Langone Medical Center, New York, New York, 10003, United States|Austin Regional Clinic, Austin, Texas, 78731, United States|Swedish Medical Center, Seattle, Washington, 98104, United States|Medizinische Universitat Wien, Vienna, 1090, Austria|UZ Leuven, Leuven, 3000, Belgium|University of Calgary - Cumming School of Medicine, Calgary, Alberta, T2N 4N1, Canada|Alberta Rheumatology, Edmonton, Alberta, T5M 0H4, Canada|Ottawa Hospital Research Institute, Ottawa, Ontario, K1H 7W9, Canada|G.R.M.O. (Groupe de recherche en maladies osseuses) Inc., Quebec, G1V 3M7, Canada|Aalborg Universitetshospital, Aalborg, 9000, Denmark|Frederiksberg Hospital, Frederiksberg, 2000, Denmark|Copenhagen University Hospital Rigshospitalet, Glostrup, 2600, Denmark|Universitaetsklinikum Bonn, Bonn, 53127, Germany|Universitaetsklinikum Duesseldorf, Duesseldorf, 40225, Germany|Johann Wolfgang Goethe University Hospital, Frankfurt am Main, 60590, Germany|Universitaetsklinikum Tuebingen, Tuebingen, 72076, Germany|Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele Ospedale Vittorio Emanuele, Catania, 95123, Italy|Azienda Ospedaliera Regionale San Carlo, Potenza/Matera, 85100, Italy|Udmurt Republic Republican Clinical Diagnostic Center, Izhevsk, 426009, Russian Federation|Research Institute of Rheumatology named after V.A.Nasonova, Moscow, 115522, Russian Federation|LLC Medical Center Zdorovaya Semiya, Novosibirsk, 630061, Russian Federation|Mechnikov North-Western State Medical University, Saint-Petersburg, 191015, Russian Federation|Regional Clinical Hospital No 1 - Tyumen, Tyumen, 625032, Russian Federation|Hospital Virgen de Macarena, Sevilla, Andalucía, 41009, Spain|Hospital Santa Creu I Sant Pau, Barcelona, 08041, Spain|Hospital La Paz, Madrid, 28046, Spain|Kantonsspital Aarau - KSA, Aarau, 5001, Switzerland|Hopital Universitaire Genevois - Beau-Sejour Hospital, Geneve, 1206, Switzerland|Kantonsspital St Gallen, Sankt Gallen, 9007, Switzerland|NHS Lothian, Western General Hospital, Edinburgh, EH16 4TJ, United Kingdom|The Leeds Teaching Hospitals NHS Trust - Chapel Allerton Hospital, Leeds, LS7 4SA, United Kingdom|Southampton University Hospitals NHS Trust, Southampton, SO16 6YD, United Kingdom Less <<
NCT04306965 Atopic Dermatitis PHASE2 COMPLETED 2022-08-18 Tufts Medical Center, Departme... More >>nt of Dermatology, Boston, Massachusetts, 02111, United States Less <<
NCT00814632 Vulvodynia PHASE2 COMPLETED 2025-02-11 William Beaumont Hospital, Roy... More >>al Oak, Michigan, 48073, United States Less <<
NCT00701311 Prostatitis|Chronic Prostatiti... More >>s With Chronic Pelvic Pain Syndrome Less << PHASE2 COMPLETED 2025-03-11 William Beaumont Hospital, Roy... More >>al Oak, Michigan, 48073, United States Less <<
NCT03022617 Psoriatic Nail|Psoriasis Vulga... More >>ris|Psoriasis Less << PHASE4 COMPLETED 2022-09-29 The Kirklin Clinic, Birmingham... More >>, Alabama, 35249, United States Less <<
NCT00889421 Uveitis PHASE1|PHASE2 TERMINATED 2025-06-11 Oregon Health & Science Univer... More >>sity, Portland, Oregon, 97239, United States Less <<
NCT00521339 Psoriasis-Type Psoriasis|Plaqu... More >>e-Type Psoriasis Less << PHASE2 COMPLETED 2009-05-01 Tufts-New England Medical Cent... More >>er Hospitals, Boston, Massachusetts, 02111, United States|Central Dermatology, Saint Louis, Missouri, 63117, United States|Oregon Medical Research Center, P.C., Portland, Oregon, 97223, United States|Baylor Research Institute, Dallas, Texas, 75246-1613, United States Less <<
NCT03521687 Central Centrifugal Cicatricia... More >>l Alopecia Less << PHASE4 COMPLETED 2021-02-12 Mount Sinai West Dermatology, ... More >>New York, New York, 10023, United States Less <<
NCT03616561 Nail Psoriasis COMPLETED 2020-07-23 Hospital General de Granollers... More >>, Granollers, Barcelona, 08402, Spain Less <<
NCT06088199 Plaque Psoriasis PHASE3 RECRUITING 2026-12-17 University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35233, United States|Affiliated Dermatology, Scottsdale, Arizona, 85255, United States|Clear Dermatology, Scottsdale, Arizona, 85255, United States|Johnson Dermatology Clinic, Fort Smith, Arkansas, 72916, United States|Avance Clinical Trials, Laguna Niguel, California, 92677, United States|University of California Irvine, Orange, California, 92868, United States|MedDerm Associates, San Diego, California, 92103, United States|Clinical Science Institute, Santa Monica, California, 90404, United States|California Dermatology Institute, Thousand Oaks, California, 91320, United States|Pediatric Skin Research, Coral Gables, Florida, 33146, United States|Ciocca Dermatology, Miami, Florida, 33173, United States|University of South Florida, Tampa, Florida, 33612, United States|NorthShore University HealthSystem, Skokie, Illinois, 60077, United States|Dawes Fretzin Clinical Research Group, LLC, Indianapolis, Indiana, 46250, United States|Southern Indiana Clinical Trials, New Albany, Indiana, 47150, United States|Great Lakes Research Group Inc- Sheffield, Bay City, Michigan, 48706, United States|Henry Ford Cancer Detroit (Brigitte Harris Cancer Pavilion), Detroit, Michigan, 48202, United States|Dermatology and Skin Cancer Center of Lees Summit, Lee's Summit, Missouri, 64064, United States|Boeson Research, Missoula, Montana, 59804, United States|Empire Dermatology, East Syracuse, New York, 13057, United States|State University of New York, Downstate Medical Center, Manhasset, New York, 11030, United States|OptiSkin Medical, New York, New York, 10029, United States|Hightower Clinical LLC, Oklahoma City, Oklahoma, 73120, United States|Dermatology Research Center of Oklahoma, PLLC, Tulsa, Oklahoma, 74132, United States|Oregon Health and Science University, Portland, Oregon, 97239, United States|Medical University of South Carolina, Charleston, South Carolina, 29425, United States|Studies in Dermatology LLC, Cypress, Texas, 77429, United States|Austin Institute for Clinical Research, Pflugerville, Texas, 78660, United States|Stride Clinical Research LLC, Sugar Land, Texas, 77479, United States|Frontier Derm Partners, Mill Creek, Washington, 98012, United States Less <<
NCT00708916 Discoid Lupus Erythematosus PHASE1|PHASE2 COMPLETED 2025-08-10 New York University Tisch Hosp... More >>ital, New York, New York, 10016, United States Less <<
NCT05767047 Beh?et's Disease|Juvenile Psor... More >>iatic Arthritis Less << PHASE3 RECRUITING 2036-03-28 General Hospital of Thessaloni... More >>ki Ippokrateio, Thessaloniki, 54642, Greece|Meir Medical Center, Kfar Saba, 4428164, Israel|Hospital Universitari i Politecnic La Fe, Valencia, Comunidad Valenciana, 46026, Spain|Hospital Universitario Ramon y Cajal, Madrid, 28034, Spain|Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara, 06100, Turkey|Istanbul Universitesi Cerrahpasa Tip Fakultesi, Istanbul, 34098, Turkey|Umraniye Egitim ve Arastirma Hastanesi, Istanbul, 34764, Turkey Less <<
NCT04102449 Psoriatic Arthritis PHASE4 WITHDRAWN 2025-02-22 Medical University of Graz, Gr... More >>az, Styria, 8010, Austria Less <<
NCT06324435 Alcohol Use Disorder PHASE1 RECRUITING 2025-02-28 Yale University, New Haven, Co... More >>nnecticut, 06510, United States Less <<
NCT01045551 Erythematotelangiectatic Rosac... More >>ea|Papulopustular Rosacea Less << PHASE2 COMPLETED 2025-04-14 Columbia University Medical Ce... More >>nter, New York, New York, 10032, United States Less <<
NCT03239106 Itch PHASE2 COMPLETED 2019-09-19 Washington University Division... More >> of Dermatology, Saint Louis, Missouri, 63108, United States Less <<
NCT04031027 Plaque Psoriasis COMPLETED 2021-01-27 SOD Clinica Dermatologica A.O.... More >>U. Riuniti Umberto I Lancisi Salesi, Ancona, AN, 60126, Italy|UOC Dermatologia ASST Spedali Civili, Brescia, BS, 25123, Italy|Dermatologia Azienda Ospedaliera Papardo, Messina, ME, 98158, Italy|Dermatologica e Venereologia Univ. A.O.U. Consorziale Policlinico, Bari, 70124, Italy|UOS Clinica Dermatologica Ospedale San Giovanni di Dio, Cagliari, 09123, Italy|Dermatologia A.O.U. Policlinico-Vittorio Emanuele PO S.Marco, Catania, 95100, Italy|UOC Dermatologia Arcispedale Sant'Anna, Cona, 44124, Italy|Dermatologia Ospedale Piero Palagi, Firenze, 50025, Italy|UOC Dermatologia A.O.U. Policlinico G. Martino, Messina, 98125, Italy|Dermatologia A.O.U. Federico II, Napoli, 80131, Italy|UOC Clinica Dermatologica A.O.U. Università della Campania Vanvitelli, Napoli, 80138, Italy|Dermatologia A.O.U. Maggiore della Carità, Novara, 28100, Italy|UOC Dermatologia e MST A.O.U. Policlinico P. Giaccone, Palermo, 90127, Italy|Clinica Dermatologica Policlinico Tor Vergata, Roma, 00133, Italy|Dermatologia e Venereologia A.O.U. Policlinico Umberto I, Roma, 00161, Italy|UOC Dermatologia Universitaria Ospedale A. Fiorini, Terracina, 04019, Italy Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.86mL

2.17mL

1.09mL

21.72mL

4.34mL

2.17mL

References

 

Historical Records

Categories