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Chemical Structure| 20362-31-6 Chemical Structure| 20362-31-6

Structure of Arctiin
CAS No.: 20362-31-6

Chemical Structure| 20362-31-6

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Arctiin is a suppressor of cyclin D1 protein expression in multiple types of human tumor cells and also shows antiviral activity against influenza A.

Synonyms: Arctii; NSC 315527; Arctigenin-4-glucoside

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Product Details of Arctiin

CAS No. :20362-31-6
Formula : C27H34O11
M.W : 534.55
SMILES Code : O=C1OC[C@H](CC2=CC=C(OC)C(OC)=C2)[C@H]1CC3=CC(OC)=C(C=C3)O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO
Synonyms :
Arctii; NSC 315527; Arctigenin-4-glucoside
MDL No. :MFCD00870630
InChI Key :XOJVHLIYNSOZOO-SWOBOCGESA-N
Pubchem ID :100528

Safety of Arctiin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of Arctiin

pyroptosis

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.87mL

0.37mL

0.19mL

9.35mL

1.87mL

0.94mL

18.71mL

3.74mL

1.87mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

[1]Matsuzaki Y, Koyama M, et al. Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep. 2008 Mar;19(3):721-7.

[2]Hayashi K, Narutaki K, et al. Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. Biol Pharm Bull. 2010;33(7):1199-205.

[3]Sun Y, Zang Z, et al. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One. 2013 May 14;8(5):e63354.

[4]Wu JG, Wu JZ, et al. Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats. Phytomedicine. 2009 Nov;16(11):1033-41.

[5]Lee JH, Lee JY, et al. Antiasthmatic action of dibenzylbutyrolactone lignans from fruits of Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea-pigs. Phytother Res. 2011 Mar;25(3):387-95.

[6]He F, Dou DQ, et al. Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS. Planta Med. 2012 May;78(8):800-6.

[7]Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, Germain D, Sakai T. Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep. 2008 Mar;19(3):721-7. PMID: 18288407.

[8]Hayashi K, Narutaki K, Nagaoka Y, Hayashi T, Uesato S. Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. Biol Pharm Bull. 2010;33(7):1199-205. doi: 10.1248/bpb.33.1199. PMID: 20606313.

[9]Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One. 2013 May 14;8(5):e63354. doi: 10.1371/journal.pone.0063354. PMID: 23691032; PMCID: PMC3653934.

 

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