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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 2316837-10-0 Chemical Structure| 2316837-10-0

Structure of ARD-69
CAS No.: 2316837-10-0

Chemical Structure| 2316837-10-0

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ARD-69 is a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. ARD-69 induces degradation of AR protein in AR-positive prostate cancer cell lines in a dose- and time-dependent manner. ARD-69 achieves DC50 values of 0.86, 0.76, and 10.4 nM in LNCaP, VCaP, and 22Rv1 AR+ prostate cancer cell lines, respectively. ARD-69 is capable of reducing the AR protein level by >95% in these prostate cancer cell lines and effectively suppressing AR-regulated gene expression.

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Details of ARD-69

CAS No. :2316837-10-0
Formula : C62H74ClFN8O7S
M.W : 1129.82
SMILES Code : CC1=C(SC=N1)C2=CC=C([C@H](CC(N3CCC(N4CCC(C#CC5=CC=C(C(N[C@H]6C(C)(C)[C@H](OC7=CC(Cl)=C(C#N)C=C7)C6(C)C)=O)C=C5)CC4)CC3)=O)NC([C@@H]8C[C@@H](O)CN8C([C@@H](NC(C9(F)CC9)=O)C(C)(C)C)=O)=O)C=C2
MDL No. :N/A

Safety of ARD-69

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501
Class:8
UN#:3261
Packing Group:

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.89mL

0.18mL

0.09mL

4.43mL

0.89mL

0.44mL

8.85mL

1.77mL

0.89mL

 

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