Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

CAS No. :	313-67-7
Formula :	C₁₇H₁₁NO₇
M.W :	341.27
SMILES Code :	O=C(C1=CC(OCO2)=C2C3=C4C=CC=C(OC)C4=CC([N+]([O-])=O)=C13)O
Synonyms :	Aristolochic acid I; TR 1736; AristA
MDL No. :	MFCD00004996
InChI Key :	BBFQZRXNYIEMAW-UHFFFAOYSA-N
Pubchem ID :	2236

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301-H311-H331-H341-H350
Precautionary Statements:	P201-P261-P280-P301+P310-P311
Class:	6.1
UN#:	1544
Packing Group:	Ⅲ

Bone marrow-derived macrophages (BMDMs)	10 mg/ml	0, 6, 12, 24, 48 hours	To study the effect of AA on macrophage polarization, results showed that AA treatment significantly increased the expression of M2-related genes.	PMC9108237
Raw264.7 cells	10 mg/ml	0, 6, 12, 24, 48 hours	To study the effect of AA on macrophage polarization, results showed that AA treatment significantly increased the expression of M2-related genes.	PMC9108237
Rat liver microsomes	10 μM	20 min	Investigation of AAI O-demethylation, identifying CYP1A and CYP2C subfamily as major catalysts	PMC4661905
Human liver microsomes	10 μM	20 min	Investigation of AAI O-demethylation, identifying CYP1A1/2 and CYP3A4 as major catalysts	PMC4661905
HEK293 cells	20 μM	24 hours	To validate KLF15 binding sites in the CPT1A and ACAA2 promoter regions by chromatin immunoprecipitation assay. Results showed that KLF15 binding to these promoter regions was maintained even after AAI treatment.	PMC8608748
HK-2 cells	20 μM	24 hours	To evaluate the protective effect of KLF15 overexpression on AAI-induced cell injury. Results showed that KLF15 overexpression partially rescued the loss of FAO in AAI-treated cells.	PMC8608748
NRK52E cells	40 μM	24 hours	To investigate the ameliorative effect of LYC on AAI-induced renal fibrosis and its mechanism. The results showed that LYC intervention activated mitophagy, reduced AAI-induced mitochondrial damage, and improved renal fibrosis by inhibiting the AKT signaling pathway.	PMC11135866
Human renal proximal tubular epithelial cell line (HK-2)	100 μM	24 hours	Evaluate the inhibitory effect of AAI on cell proliferation and DNA damage, SFII significantly alleviated AAI-induced DNA damage and apoptosis.	PMC9876410
Human normal liver cell line (L02)	20 μM, 50 μM	24 hours, 48 hours	Evaluate the inhibitory effect of AAI on cell proliferation and DNA damage, SFII significantly alleviated AAI-induced DNA damage and apoptosis.	PMC9876410
HK-2 cells	5 μM and 10 μM	4 hours	To study AAI-induced mitochondrial acidification, results showed increased mitochondrial acidification with higher AAI concentrations.	PMC11415585
Supersomes™ (recombinant CYP enzymes expressed in insect cells)	10 μM		Evaluation of cytochrome b5 effect on AAI oxidation, identifying human CYP1A1 and 1A2 as major enzymes for AAI oxidation	PMC4661905

{[proInfo.proName]}

CAS No.: 313-67-7

{[proInfo.proName]}

CAS No.: 313-67-7

Alternative Products

Product Details of Aristolochic acid A

Safety of Aristolochic acid A

Related Pathways of Aristolochic acid A

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

C57BL/6 mice	Klf15PTKO mice	Intraperitoneal injection	3 mg/kg	Every 3 days for 2 weeks	To evaluate the effect of PT-specific KLF15 deletion on AAI-induced kidney injury. Results showed that Klf15PTKO mice exhibited more severe tubular injury and kidney function decline after AAI treatment.	PMC8608748
Mice	AAI-induced nephrotoxicity model	Tail vein injection	200 μM	Five times per week for two weeks	To study AAI-induced nephrotoxicity and mitochondrial acidification, results showed AAI caused renal injury and mitochondrial acidification, which was mitigated by LC co-treatment.	PMC11415585
C57BL/6 mice	AAI-induced renal fibrosis model	Oral gavage	10 mg/kg	Once daily for 28 days	To investigate the ameliorative effect of LYC on AAI-induced renal fibrosis and its mechanism. The results showed that LYC intervention alleviated AAI-induced renal histopathological damage, restored renal function, and improved renal fibrosis by inhibiting the TGFB signaling pathway and activating mitophagy.	PMC11135866
C57BL/6 mice	AAI-induced hepatotoxicity Mice model	Intraperitoneal injection	2 mg/kg	Once daily for 4 weeks or 8 weeks	To investigate the mechanisms of AAI-induced hepatotoxicity, results showed that AAI exposure led to body weight loss, liver injury, inflammatory cell infiltration, and increased levels of ALT and AST.	PMC9635452
Mice	AAN model	Intraperitoneal injection	10 mg/kg	1, 3, 7, 14, 28 days	To study AA-induced renal fibrosis, results showed that AA treatment significantly increased renal fibrosis and macrophage M2 polarization.	PMC9108237
C57BL/6 mice	Acute renal injury model and renal fibrosis model	Intraperitoneal injection	5 mg/kg, 10 mg/kg	Three consecutive days or 14 days after a single dose	Evaluate the protective effect of SFII on AAI-induced renal injury and fibrosis, SFII effectively attenuated acute renal injury and fibrosis caused by AAI in vivo.	PMC9876410
C57 BL/6 mice	AA-induced nephrotoxicity model	Intraperitoneal injection	2 mg/kg	Once a day for 4 weeks	Evaluate AA-induced nephrotoxicity and metabolic disorders	PMC8935225
C57BL/6J mice	AAI-induced acute kidney injury model	Intraperitoneal injection	10 mg/kg	Single injection, sacrificed after 3 days	To study the role of PSTPIP2 in AAI-induced acute kidney injury, it was found that conditional knock-in of Pstpip2 alleviated kidney injury and apoptosis.	PMC10906995
Sprague-Dawley rats	Hepatocellular carcinoma model	Oral	20, 50, or 100 mg/kg	Single dose	To evaluate the tumor-initiating or -promoting activity of AAI. Results showed that high-dose AAI (10 mg/kg) promoted clonal expansion but did not induce HCC.	PMC8633323
Sprague-Dawley rats	Hepatocellular carcinoma model	Oral	0.1, 1, or 10 mg/kg	5 days a week for 6 weeks (medium-term study) or 52 weeks (long-term study)	To evaluate the tumor-initiating or -promoting activity of AAI. Results showed that high-dose AAI (10 mg/kg) promoted clonal expansion but did not induce HCC.	PMC8633323
Mice	Trp53(+/+), Trp53(+/-), and Trp53(-/-) mice	Intraperitoneal injection	3.5 mg/kg	Daily for six days	To investigate the impact of p53 on AAI-induced gene expression in vivo, results showed that AAI significantly altered gene expression in kidneys of Trp53(+/+), Trp53(+/-), and Trp53(-/-) mice	PMC6940885
C57BL/6 mice	AAN model	Intraperitoneal injection	3 mg/kg	Twice a week for 4 weeks followed by 4 weeks of remodeling time	To investigate whether AA induces renal aging, results showed AA caused renal atrophy, tubulointerstitial fibrosis, and renal functional decline, accompanied by increased renal p16 mRNA expression and SA-β-gal activity	PMC8618437

NCT03066921	End Stage Renal Disease	Not Applicable	Completed	-	Taiwan ... More >> Tungs' Taichung MetroHarbour Hospital Taichung, Taiwan Less <<
NCT01503645	-		Unknown	-	Taiwan ... More >> Far Estern Memorial Hospital Not yet recruiting Pan-Chiao, Taipei, Taiwan, 22060 National Taiwan University Hospital Recruiting Taipei, Taiwan, 10051 Contact: Kwan-Dun Wu, MD, PhD +886-2-23123456 ext 5014 kdw@ntumc.org Principal Investigator: Fe-Lin L Wu, Ph.D. Less <<
NCT00867633	-		Unknown	March 2012	Taiwan ... More >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Yeong-Shiau Pu, Ph.D. 886-2-23123456 ext 65249 yspu@ntu.edu.tw Less <<

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	2.93mL 0.59mL 0.29mL	14.65mL 2.93mL 1.47mL	29.30mL 5.86mL 2.93mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed