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Chemical Structure| 2230854-93-8 Chemical Structure| 2230854-93-8

Structure of ARN-21934
CAS No.: 2230854-93-8

Chemical Structure| 2230854-93-8

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ARN-21934 is a highly selective human topoisomerase II α (TOP2A) inhibitor with good blood-brain barrier (BBB) permeability. ARN-21934 has an IC50 of 2 μM for DNA relaxation, showing higher efficacy compared to the anticancer drug etoposide (IC50 = 120 μM) and demonstrating promising pharmacokinetic properties in vivo, making it a potential anticancer lead compound.

Synonyms: ARN-21934

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Product Details of ARN-21934

CAS No. :2230854-93-8
Formula : C21H24N6
M.W : 360.46
SMILES Code : NC1CC2=C(NC3=CC=C(N(C)C)C=C3)N=C(C4=CC=NC=C4)N=C2CC1
Synonyms :
ARN-21934
MDL No. :MFCD34179494

Safety of ARN-21934

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of ARN-21934

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1 mM

5 mM

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2.77mL

0.55mL

0.28mL

13.87mL

2.77mL

1.39mL

27.74mL

5.55mL

2.77mL

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