Structure of ARQ 531
CAS No.: 2095393-15-8
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity.
Synonyms: Nemtabrutinib; MK-1026
4.5
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 2095393-15-8 |
Formula : | C25H23ClN4O4 |
M.W : | 478.93 |
SMILES Code : | ClC1=C(C(C2=CN=C3C2=C(N[C@H]4CO[C@H](CO)CC4)NC=N3)=O)C=CC(OC5=CC=CC=C5)=C1 |
Synonyms : |
Nemtabrutinib; MK-1026
|
MDL No. : | MFCD31692379 |
InChI Key : | JSFCZQSJQXFJDS-QAPCUYQASA-N |
Pubchem ID : | 129045720 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03162536 | Lymphoma, B-Cell|Small Lymphoc... More >>ytic Lymphoma|Chronic Lymphocytic Leukemia|Waldenstrom Macroglobulinemia|Mantle Cell Lymphoma|Diffuse Large B Cell Lymphoma|Richter's Transformation|Follicular Lymphoma|Marginal Zone Lymphoma Less << | PHASE1|PHASE2 | ACTIVE_NOT_RECRUITING | 2025-09-15 | Mayo Clinic Hospital ( Site 01... More >>40), Scottsdale, Arizona, 85259, United States|UCLA Hematology & Oncology ( Site 0017), Los Angeles, California, 90095, United States|Colorado Blood Cancer Institute ( Site 0225), Denver, Colorado, 80218, United States|University of Michigan ( Site 0018), Ann Arbor, Michigan, 48109, United States|Mayo Clinic - Rochester ( Site 0138), Rochester, Minnesota, 58905, United States|Duke Cancer Center ( Site 0067), Durham, North Carolina, 27710, United States|The Ohio State University Wexner Medical Center ( Site 0056), Columbus, Ohio, 43210, United States|Tennessee Oncology, PLLC ( Site 0020), Nashville, Tennessee, 37203, United States|UT Southwestern Medical Center ( Site 0116), Dallas, Texas, 75390-8562, United States|University of Utah, Huntsman Cancer Institute ( Site 0122), Salt Lake City, Utah, 84112, United States Less << |
NCT06586671 | Hematological Malignancy | PHASE1 | COMPLETED | 2023-11-13 | QPS-MRA, LLC-Early Phase (Site... More >> 0002), South Miami, Florida, 33143, United States Less << |
NCT06772805 | Healthy | PHASE1 | COMPLETED | 2023-12-12 | Labcorp Clinical Research Unit... More >> Inc. (Site 0001), Honolulu, Hawaii, 96813, United States Less << |
NCT06442436 | Hepatic Impairment (HI) | PHASE1 | RECRUITING | 2025-08-08 | Clinical Pharmacology of Miami... More >> ( Site 0003), Miami, Florida, 33014-3616, United States|Orlando Clinical Research Center ( Site 0001), Orlando, Florida, 32809, United States|Texas Liver Institute ( Site 0002), San Antonio, Texas, 78215, United States Less << |
NCT06772818 | Healthy | PHASE1 | COMPLETED | 2024-02-16 | Labcorp Clinical Research Unit... More >> Inc. (Site 0001), Honolulu, Hawaii, 96813, United States Less << |
NCT05347225 | Hematological Malignancies | PHASE1 | ACTIVE_NOT_RECRUITING | 2027-04-30 | Guangdong Provincial People's ... More >>Hospital-hematology department ( Site 1002), Guangzhou, Guangdong, 510000, China|SUN YAT-SEN UNIVERSITY CANCER CENTRE-Internal medicine ( Site 1007), Guangzhou, Guangdong, 511400, China|Henan Cancer Hospital-hematology department ( Site 1003), Zhengzhou, Henan, 450008, China|Hunan Cancer Hospital ( Site 1004), Changsha, Hunan, 410013, China|Institute of hematology&blood disease hospital-Hematology ( Site 1001), Tianjin, Tianjin, 300020, China Less << |
NCT05673460 | Mature B-cell Neoplasms | PHASE1 | ACTIVE_NOT_RECRUITING | 2026-03-30 | Nagoya University Hospital ( S... More >>ite 0003), Nagoya, Aichi, 466-8560, Japan|National Cancer Center Hospital East ( Site 0002), Kashiwa, Chiba, 2778577, Japan|Kindai University Hospital ( Site 0006), Osakasayama, Osaka, 589-8511, Japan|Chiba Cancer Center ( Site 0005), Chiba, 260-8717, Japan|Kyushu University Hospital ( Site 0008), Fukuoka, 812-8582, Japan|Okayama University Hospital ( Site 0007), Okayama, 700-8558, Japan|Yamagata University Hospital ( Site 0001), Yamagata, 990-9585, Japan Less << |
NCT04728893 | Hematologic Malignancies|Walde... More >>nstroms Macroglobulinaemia|Non-Hodgkins Lymphoma|Chronic Lymphocytic Leukaemia Less << | PHASE2 | RECRUITING | 2027-03-19 | Highlands Oncology Group ( Sit... More >>e 2728), Springdale, Arkansas, 72762, United States|University of California San Diego Moores Cancer Center ( Site 2717), La Jolla, California, 92093-0698, United States|Lundquist Institute for Biomedical Innovation at Harbor-UCLA-Hematology and Medical Oncology ( Site, Torrance, California, 90502, United States|Colorado Blood Cancer Institute ( Site 2726), Denver, Colorado, 80218, United States|The University of Louisville, James Graham Brown Cancer Center ( Site 2729), Louisville, Kentucky, 40202, United States|Mayo Clinic - Rochester ( Site 2706), Rochester, Minnesota, 55905, United States|Astera Cancer Care ( Site 2732), East Brunswick, New Jersey, 08816, United States|John Theurer Cancer Center at Hackensack University Medical Center ( Site 2704), Hackensack, New Jersey, 07601, United States|Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 2708), Fargo, North Dakota, 58122, United States|UT Southwestern-Harold C. Simmons Cancer Center ( Site 2730), Dallas, Texas, 75390, United States|Medical Oncology Associates (Summit Cancer Centers) ( Site 2710), Spokane, Washington, 99208, United States|Hospital Aleman ( Site 0102), Ciudad Autonoma de Buenos Aires, Buenos Aires, C1118AAT, Argentina|Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 0103), Buenos Aires, Caba, C1431FWO, Argentina|Fundacion Estudios Clinicos ( Site 0112), Rosario, Santa Fe, S2000DEJ, Argentina|FUNDALEU ( Site 0104), Caba, C1114AAN, Argentina|Hospital Privado Universitario de Córdoba ( Site 0107), Cordoba, X5016KEH, Argentina|Fundacion Centro Oncologico de Integración Regional-Medical Oncology ( Site 0110), Mendoza, M5500AYB, Argentina|Nepean Hospital-Nepean Cancer Care Centre ( Site 0204), Sydney, New South Wales, 2747, Australia|Box Hill Hospital ( Site 0203), Box Hill, Victoria, 3128, Australia|Sir Charles Gairdner Hospital ( Site 0200), Nedlands, Western Australia, 6009, Australia|Hospital das Clinicas FMUSP-Pesquisa Clínica Hematologia ( Site 0303), S?o Paulo, Sao Paulo, 05403-000, Brazil|Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0300), Rio de Janeiro, 20231-050, Brazil|BP - A Beneficencia Portuguesa de S?o Paulo ( Site 0302), Sao Paulo, 01321-001, Brazil|Hospital Paulistano - Amil Clinical Research ( Site 0311), Sao Paulo, 01321-001, Brazil|Arthur J.E. Child Comprehensive Cancer Centre ( Site 0401), Calgary, Alberta, T2N 5G2, Canada|The Ottawa Hospital ( Site 0404), Ottawa, Ontario, K1H 8L6, Canada|Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0406), Toronto, Ontario, M5G 2M9, Canada|CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0403), Montreal, Quebec, H1T 2M4, Canada|Jewish General Hospital ( Site 0400), Montreal, Quebec, H3T 1E2, Canada|Anhui Provincial Hospital ( Site 2808), Hefei, Anhui, 230071, China|Peking University Third Hospital-Hematology ( Site 2827), Beijing, Beijing, 100191, China|The Second Affiliated Hospital of Chongqing Medical University ( Site 2825), Chongqing, Chongqing, 400072, China|Sun Yat-sen University Cancer Center-Internal Medicine ( Site 2824), Guangzhou, Guangdong, 510060, China|Guangxi Medical University - Liuzhou Renmin Hospital ( Site 2817), Liuzhou, Guangxi, 545006, China|Guangxi Medical University Affiliated Tumor Hospital ( Site 2814), Nanning, Guangxi, 530021, China|Henan Cancer Hospital-hematology department ( Site 2802), Zhengzhou, Henan, 450008, China|Wuhan Union Hospital ( Site 2816), Wuhan, Hubei, 430010, China|The Second Xiangya Hospital of Central South University ( Site 2820), Changsha, Hunan, 410011, China|Hunan Cancer Hospital ( Site 2822), Changsha, Hunan, 410013, China|Jiangsu Province Hospital ( Site 2823), Nanjing, Jiangsu, 210029, China|The Affiliated Hospital of Xuzhou Medical College ( Site 2818), Xuzhou, Jiangsu, 221000, China|The First Affiliated Hospital of Nanchang University ( Site 2815), Nanchang, Jiangxi, 330006, China|The First Hospital of Jilin University-Hematology ( Site 2803), Changchun, Jilin, 130021, China|Fudan University Shanghai Cancer Center ( Site 2801), Shanghai, Shanghai, 200032, China|Huashan Hospital, Fudan University ( Site 2821), Shanghai, Shanghai, 200040, China|West China Hospital Sichuan University ( Site 2810), Cheng Du, Sichuan, 610041, China|Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Unio, Tianjin, Tianjin, 301617, China|The First Affiliated Hospital, Zhejiang University ( Site 2826), Hangzhou, Zhejiang, 310002, China|Fakultní nemocnice Brno Bohunice-Interni hematologicka a onkologicka klinika ( Site 0600), Brno, Brno-mesto, 625 00, Czechia|Fakultni nemocnice Hradec Kralove ( Site 0601), Hradec Kralove, 50005, Czechia|Aarhus University Hospital ( Site 0702), Aarhus N, Midtjylland, 8200, Denmark|Aalborg Universitetshospital ( Site 0703), Aalborg, Nordjylland, 9000, Denmark|Sjaellands Universitetshospital Roskilde ( Site 0701), Roskilde, Sjaelland, 4000, Denmark|Odense University Hospital ( Site 0705), Odense C, Syddanmark, 5000, Denmark|Centre Hospitalier Universitaire de Nice - H?pital l'Archet ( Site 0810), Nice, Alpes-Maritimes, 06202, France|Institut Paoli-Calmettes ( Site 0803), Marseille, Bouches-du-Rhone, 13009, France|Centre Hospitalier Lyon-Sud ( Site 0804), Pierre Benite, Rhone-Alpes, 69495, France|Centre Hospitalier de Versailles ( Site 0809), Le Chesnay, Yvelines, 78150, France|Hopital Saint Louis ( Site 0805), Paris, 75010, France|Universitaetsklinikum Ulm ( Site 0906), Ulm, Baden-Wurttemberg, 89081, Germany|Universitaetsklinikum Koeln ( Site 0901), Koeln, Nordrhein-Westfalen, 50937, Germany|St. Marien-Krankenhaus Siegen ( Site 0914), Siegen, Nordrhein-Westfalen, 57072, Germany|Universitaetsklinikum Carl Gustav Carus ( Site 0902), Dresden, Sachsen, 01307, Germany|Pecsi Tudomanyegyetem Altalanos Orvostudomanyi Kar ( Site 1202), Pecs, Baranya, 7624, Hungary|Debreceni Egyetem Klinikai Kozpont ( Site 1201), Debrecen, Hajdu-Bihar, 4032, Hungary|Szabolcs Szatmár Bereg Vármegyei Oktatókórház ( Site 1206), Nyiregyhaza, Szabolcs-Szatmar-Bereg, 4400, Hungary|Orszagos Onkologiai Intezet ( Site 1200), Budapest, 1122, Hungary|Beaumont Hospital ( Site 2900), Dublin, Dublin 9, Ireland|University Hospital Limerick ( Site 2903), Limerick, V94 F858, Ireland|Ha Emek Medical Center ( Site 1305), Afula, 1834111, Israel|Soroka Medical Center ( Site 1307), Beer-Sheva, 8410101, Israel|Rambam Medical Center ( Site 1301), Haifa, 3109601, Israel|Hadassah Ein Karem Jerusalem ( Site 1300), Jerusalem, 9112001, Israel|Chaim Sheba Medical Center ( Site 1302), Ramat Gan, 5262001, Israel|Kaplan Medical Center ( Site 1304), Rehovot, 7610001, Israel|Sourasky Medical Center ( Site 1303), Tel Aviv, 6423906, Israel|Istituto Tumori Giovanni Paolo II ( Site 1409), Bari, 70124, Italy|A.O. Universitaria Policlinico S. Orsola-Malpighi ( Site 1400), Bologna, 40138, Italy|ASST Spedali Civili di Brescia ( Site 1408), Brescia, 25123, Italy|IRCCS Ospedale San Raffaele ( Site 1402), Milano, 20132, Italy|Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1403), Napoli, 80131, Italy|Fondazione IRCCS Policlinico San Matteo ( Site 1407), Pavia, 27100, Italy|IRCCS - Arcispedale Santa Maria Nuova ( Site 1405), Reggio Emilia, 42123, Italy|Policlinico Umberto I ( Site 1404), Roma, 00161, Italy|Severance Hospital Yonsei University Health System ( Site 2201), Seoul, 03722, Korea, Republic of|Samsung Medical Center ( Site 2200), Seoul, 06351, Korea, Republic of|Uniwersytecki Szpital Kliniczny-Klinika Hematologii, Nowotworow Krwi i Transplantacji Szpiku ( Site, Wroclaw, Dolnoslaskie, 50-367, Poland|Pratia MCM Krakow ( Site 1601), Krakow, Malopolskie, 30-727, Poland|Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Kilinka Onkologii I Hematologii ( Site, Warszawa, Mazowieckie, 02-781, Poland|Szpital Wojewódzki w Opolu-Hematology Department ( Site 1607), Opole, Opolskie, 45-061, Poland|Szpitale Pomorskie Sp. z o.o. ( Site 1600), Gdynia, Pomorskie, 81-519, Poland|Spitalul Clinic Col?ea ( Site 1805), Bucure?ti, Bucuresti, 030171, Romania|Ovidius Clinical Hospital ( Site 1804), Ovidiu, Constanta, 905900, Romania|Centrul de Diagnostic si Tratament Oncologic Brasov ( Site 1802), Brasov, 500052, Romania|Institutul Regional de Oncologie Iasi ( Site 1801), Iasi, 700483, Romania|Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 2000), Hospitalet de Llobregat, Barcelona, 08908, Spain|Hospital Universitario de Salamanca ( Site 2002), Salamanca, Castilla Y Leon, 37007, Spain|CHUAC-Complejo Hospitalario Universitario A Coru?a ( Site 2005), A Coru?a, La Coruna, 15006, Spain|Hospital General Universitario de Alicante ( Site 2007), Alicante, 03010, Spain|Hospital Universitari Vall d'Hebron ( Site 2001), Barcelona, 08035, Spain|Hospital Universitario 12 de Octubre ( Site 2003), Madrid, 28041, Spain|Inselspital Bern ( Site 2303), Bern, Berne, 3010, Switzerland|Istituto Oncologica della Svizzera Italiana (IOSI) ( Site 2302), Bellinzona, Ticino, 6500, Switzerland|Mega Medipol-Hematology ( Site 2406), Stanbul, Istanbul, 34214, Turkey|Ankara Universitesi Tip Fakultesi Cebeci Hastanesi ( Site 2400), Ankara, 06590, Turkey|VKV Amerikan Hastanesi ( Site 2403), Istanbul, 34365, Turkey|Sisli Florence Nightingale Hastanesi ( Site 2407), Istanbul, 34381, Turkey|Dokuz Eylül üniversitesi-Hematology ( Site 2402), Izmir, 35340, Turkey|MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( S, Cherkassy, Cherkaska Oblast, 18009, Ukraine|Communal non-profit enterprise "Regional clinical hospital o-Hematology Department ( Site 2510), Ivano-Frankivsk, Ivano-Frankivska Oblast, 76008, Ukraine|Instit. of Blood Transfusion Medicine of the National Academy ( Site 2506), Lviv, Lvivska Oblast, 79044, Ukraine|National Cancer Institute ( Site 2507), Kyiv, 03022, Ukraine|Kyiv City Clinical Hospital 9 ( Site 2502), Kyiv, 04112, Ukraine|Bristol Haematology and Oncology Centre ( Site 2610), Bristol, Bristol, City Of, BS2 8ED, United Kingdom|Nottingham University Hospitals NHS Trust. City Hospital Campus ( Site 2601), Nottingham, England, NG5 1PF, United Kingdom|GenesisCare - Windsor ( Site 2608), Windsor, England, SL4 3HD, United Kingdom|Sarah Cannon Research Institute UK ( Site 2612), London, London, City Of, W1G 6AD, United Kingdom|GenesisCare - Oxford ( Site 2607), Oxford, Oxfordshire, OX4 6LB, United Kingdom|GenesisCare - Cambridge ( Site 2611), Newmarket, Suffolk, CB8 7XN, United Kingdom|The Royal Marsden NHS Foundation Trust. ( Site 2606), Sutton, Surrey, SM2 5PT, United Kingdom|The Christie NHS Foundation Trust ( Site 2602), Manchester, M20 4BX, United Kingdom Less << |
Tags: ARQ 531 | Nemtabrutinib | Benzene Compounds | BTK | Organic Building Blocks | Protein Tyrosine Kinase/RTK | Angiogenesis | 2095393-15-8
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
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P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
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P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
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P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
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P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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